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Side-by-side financial comparison of AC Immune SA (ACIU) and Align Technology (ALGN). Click either name above to swap in a different company.
Align Technology is the larger business by last-quarter revenue ($1.0B vs $1.4M, roughly 729.2× AC Immune SA). Align Technology runs the higher net margin — 13.0% vs -1622.4%, a 1635.4% gap on every dollar of revenue. On growth, AC Immune SA posted the faster year-over-year revenue change (90.1% vs 5.3%).
AC Immune SA is a clinical-stage biopharmaceutical company focused on developing innovative therapeutics and diagnostic solutions for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and rare tauopathies. It operates globally, partners with leading pharmaceutical enterprises, and prioritizes addressing unmet medical needs in neurological care segments.
Align Technology, Inc., a medical device company, designs, manufactures, and markets Invisalign clear aligners and iTero intraoral scanners and services for orthodontists and general practitioner dentists, and restorative and aesthetic dentistry. It operates in two segments, Clear Aligner; and Scanners and Services. The Clear Aligner segment consists of comprehensive products, including Invisalign comprehensive treatment that addresses the orthodontic needs of teenage patients, such as mandib...
ACIU vs ALGN — Head-to-Head
Income Statement — Q2 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $1.4M | $1.0B |
| Net Profit | $-23.3M | $135.8M |
| Gross Margin | — | 65.3% |
| Operating Margin | -1484.5% | 14.8% |
| Net Margin | -1622.4% | 13.0% |
| Revenue YoY | 90.1% | 5.3% |
| Net Profit YoY | 6.9% | 30.8% |
| EPS (diluted) | — | $1.88 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $1.0B | ||
| Q3 25 | — | $995.7M | ||
| Q2 25 | $1.4M | $1.0B | ||
| Q1 25 | — | $979.3M | ||
| Q4 24 | — | $995.2M | ||
| Q3 24 | — | $977.9M | ||
| Q2 24 | $755.7K | $1.0B | ||
| Q1 24 | — | $997.4M |
| Q4 25 | — | $135.8M | ||
| Q3 25 | — | $56.8M | ||
| Q2 25 | $-23.3M | $124.6M | ||
| Q1 25 | — | $93.2M | ||
| Q4 24 | — | $103.8M | ||
| Q3 24 | — | $116.0M | ||
| Q2 24 | $-25.0M | $96.6M | ||
| Q1 24 | — | $105.0M |
| Q4 25 | — | 65.3% | ||
| Q3 25 | — | 64.2% | ||
| Q2 25 | — | 69.9% | ||
| Q1 25 | — | 69.5% | ||
| Q4 24 | — | 70.0% | ||
| Q3 24 | — | 69.7% | ||
| Q2 24 | — | 70.3% | ||
| Q1 24 | — | 70.0% |
| Q4 25 | — | 14.8% | ||
| Q3 25 | — | 9.7% | ||
| Q2 25 | -1484.5% | 16.1% | ||
| Q1 25 | — | 13.4% | ||
| Q4 24 | — | 14.5% | ||
| Q3 24 | — | 16.6% | ||
| Q2 24 | -3051.1% | 14.3% | ||
| Q1 24 | — | 15.5% |
| Q4 25 | — | 13.0% | ||
| Q3 25 | — | 5.7% | ||
| Q2 25 | -1622.4% | 12.3% | ||
| Q1 25 | — | 9.5% | ||
| Q4 24 | — | 10.4% | ||
| Q3 24 | — | 11.9% | ||
| Q2 24 | -3313.0% | 9.4% | ||
| Q1 24 | — | 10.5% |
| Q4 25 | — | $1.88 | ||
| Q3 25 | — | $0.78 | ||
| Q2 25 | — | $1.72 | ||
| Q1 25 | — | $1.27 | ||
| Q4 24 | — | $1.40 | ||
| Q3 24 | — | $1.55 | ||
| Q2 24 | — | $1.28 | ||
| Q1 24 | — | $1.39 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $28.3M | $1.1B |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $82.2M | $4.0B |
| Total Assets | $209.2M | $6.2B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $1.1B | ||
| Q3 25 | — | $1.0B | ||
| Q2 25 | $28.3M | $901.2M | ||
| Q1 25 | — | $873.0M | ||
| Q4 24 | — | $1.0B | ||
| Q3 24 | — | $1.0B | ||
| Q2 24 | $56.7M | $761.4M | ||
| Q1 24 | — | $865.8M |
| Q4 25 | — | $4.0B | ||
| Q3 25 | — | $4.0B | ||
| Q2 25 | $82.2M | $3.9B | ||
| Q1 25 | — | $3.8B | ||
| Q4 24 | — | $3.9B | ||
| Q3 24 | — | $3.9B | ||
| Q2 24 | $135.8M | $3.8B | ||
| Q1 24 | — | $3.8B |
| Q4 25 | — | $6.2B | ||
| Q3 25 | — | $6.2B | ||
| Q2 25 | $209.2M | $6.2B | ||
| Q1 25 | — | $6.1B | ||
| Q4 24 | — | $6.2B | ||
| Q3 24 | — | $6.4B | ||
| Q2 24 | $261.3M | $6.2B | ||
| Q1 24 | — | $6.2B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | — | $223.2M |
| Free Cash FlowOCF − Capex | — | $187.3M |
| FCF MarginFCF / Revenue | — | 17.9% |
| Capex IntensityCapex / Revenue | — | 3.4% |
| Cash ConversionOCF / Net Profit | — | 1.64× |
| TTM Free Cash FlowTrailing 4 quarters | — | $490.8M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $223.2M | ||
| Q3 25 | — | $188.7M | ||
| Q2 25 | — | $128.7M | ||
| Q1 25 | — | $52.7M | ||
| Q4 24 | — | $286.1M | ||
| Q3 24 | — | $263.7M | ||
| Q2 24 | — | $159.8M | ||
| Q1 24 | — | $28.7M |
| Q4 25 | — | $187.3M | ||
| Q3 25 | — | $169.0M | ||
| Q2 25 | — | $107.2M | ||
| Q1 25 | — | $27.4M | ||
| Q4 24 | — | $263.1M | ||
| Q3 24 | — | $233.9M | ||
| Q2 24 | — | $106.4M | ||
| Q1 24 | — | $19.3M |
| Q4 25 | — | 17.9% | ||
| Q3 25 | — | 17.0% | ||
| Q2 25 | — | 10.6% | ||
| Q1 25 | — | 2.8% | ||
| Q4 24 | — | 26.4% | ||
| Q3 24 | — | 23.9% | ||
| Q2 24 | — | 10.3% | ||
| Q1 24 | — | 1.9% |
| Q4 25 | — | 3.4% | ||
| Q3 25 | — | 2.0% | ||
| Q2 25 | — | 2.1% | ||
| Q1 25 | — | 2.6% | ||
| Q4 24 | — | 2.3% | ||
| Q3 24 | — | 3.0% | ||
| Q2 24 | — | 5.2% | ||
| Q1 24 | — | 0.9% |
| Q4 25 | — | 1.64× | ||
| Q3 25 | — | 3.33× | ||
| Q2 25 | — | 1.03× | ||
| Q1 25 | — | 0.57× | ||
| Q4 24 | — | 2.76× | ||
| Q3 24 | — | 2.27× | ||
| Q2 24 | — | 1.66× | ||
| Q1 24 | — | 0.27× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
