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Side-by-side financial comparison of Alector, Inc. (ALEC) and Scilex Holding Co (SCLX). Click either name above to swap in a different company.
Alector, Inc. is the larger business by last-quarter revenue ($6.2M vs $4.8M, roughly 1.3× Scilex Holding Co). On growth, Scilex Holding Co posted the faster year-over-year revenue change (-67.8% vs -88.5%). Over the past eight quarters, Scilex Holding Co's revenue compounded faster (-33.6% CAGR vs -37.4%).
Alector, Inc. is a clinical-stage biopharmaceutical company focused on developing innovative immunotherapies for neurodegenerative diseases. Its product pipeline targets unmet medical needs including Alzheimer’s disease, frontotemporal dementia, and Parkinson’s disease, and it collaborates with global pharmaceutical partners to advance candidate therapies through clinical trials.
Scilex Holding Co is a commercial-stage biopharmaceutical firm focused on developing and commercializing innovative non-opioid pain management therapies for acute and chronic pain segments. It primarily serves the US market, offering prescription and over-the-counter pain relief solutions for patients and healthcare providers.
ALEC vs SCLX — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $6.2M | $4.8M |
| Net Profit | — | $-46.1M |
| Gross Margin | — | 45.5% |
| Operating Margin | — | -2317.8% |
| Net Margin | — | -961.9% |
| Revenue YoY | -88.5% | -67.8% |
| Net Profit YoY | -1696.9% | -613.7% |
| EPS (diluted) | — | $-4.63 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $6.2M | $4.8M | ||
| Q3 25 | $3.3M | $10.6M | ||
| Q2 25 | $7.9M | $9.9M | ||
| Q1 25 | $3.7M | $5.0M | ||
| Q4 24 | $54.2M | $14.9M | ||
| Q3 24 | $15.3M | $14.4M | ||
| Q2 24 | $15.1M | $16.4M | ||
| Q1 24 | $15.9M | $10.9M |
| Q4 25 | — | $-46.1M | ||
| Q3 25 | $-34.7M | $-257.8M | ||
| Q2 25 | $-30.5M | $-44.0M | ||
| Q1 25 | $-40.5M | $-26.1M | ||
| Q4 24 | $-2.1M | $-6.5M | ||
| Q3 24 | $-42.2M | $-4.4M | ||
| Q2 24 | $-38.7M | $-37.6M | ||
| Q1 24 | $-36.1M | $-24.4M |
| Q4 25 | — | 45.5% | ||
| Q3 25 | — | 68.5% | ||
| Q2 25 | — | 66.9% | ||
| Q1 25 | — | 72.3% | ||
| Q4 24 | — | 68.5% | ||
| Q3 24 | — | 73.9% | ||
| Q2 24 | — | 73.2% | ||
| Q1 24 | — | 64.7% |
| Q4 25 | — | -2317.8% | ||
| Q3 25 | -1153.6% | -1766.2% | ||
| Q2 25 | -433.6% | -207.2% | ||
| Q1 25 | -1216.5% | -557.5% | ||
| Q4 24 | -13.4% | -190.5% | ||
| Q3 24 | -315.7% | -138.0% | ||
| Q2 24 | -302.4% | -95.4% | ||
| Q1 24 | -275.0% | -179.0% |
| Q4 25 | — | -961.9% | ||
| Q3 25 | -1063.4% | -2441.5% | ||
| Q2 25 | -387.7% | -445.1% | ||
| Q1 25 | -1101.6% | -521.2% | ||
| Q4 24 | -3.8% | -43.4% | ||
| Q3 24 | -275.2% | -30.4% | ||
| Q2 24 | -256.4% | -229.6% | ||
| Q1 24 | -227.0% | -224.0% |
| Q4 25 | — | $-4.63 | ||
| Q3 25 | $-0.34 | $-22.17 | ||
| Q2 25 | $-0.30 | $-7.42 | ||
| Q1 25 | $-0.41 | $-2.26 | ||
| Q4 24 | $-0.02 | $8.53 | ||
| Q3 24 | $-0.43 | $-0.58 | ||
| Q2 24 | $-0.40 | $-7.67 | ||
| Q1 24 | $-0.38 | $-8.33 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $256.0M | $5.0M |
| Total DebtLower is stronger | $10.0M | — |
| Stockholders' EquityBook value | $30.6M | $-207.8M |
| Total Assets | $293.2M | $365.0M |
| Debt / EquityLower = less leverage | 0.33× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $256.0M | $5.0M | ||
| Q3 25 | $291.1M | $878.0K | ||
| Q2 25 | $307.3M | $4.1M | ||
| Q1 25 | $354.6M | $5.8M | ||
| Q4 24 | $413.4M | $3.3M | ||
| Q3 24 | $457.2M | $77.0K | ||
| Q2 24 | $503.3M | $6.9M | ||
| Q1 24 | $562.1M | $1.8M |
| Q4 25 | $10.0M | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $10.0M | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $30.6M | $-207.8M | ||
| Q3 25 | $57.7M | $-176.9M | ||
| Q2 25 | $71.2M | $-249.0M | ||
| Q1 25 | $94.6M | $-211.5M | ||
| Q4 24 | $126.8M | $-192.6M | ||
| Q3 24 | $118.9M | $-211.3M | ||
| Q2 24 | $150.6M | $-214.7M | ||
| Q1 24 | $178.9M | $-189.8M |
| Q4 25 | $293.2M | $365.0M | ||
| Q3 25 | $335.3M | $275.9M | ||
| Q2 25 | $356.4M | $83.8M | ||
| Q1 25 | $408.3M | $79.0M | ||
| Q4 24 | $468.3M | $93.0M | ||
| Q3 24 | $516.0M | $100.4M | ||
| Q2 24 | $570.7M | $104.5M | ||
| Q1 24 | $635.5M | $91.2M |
| Q4 25 | 0.33× | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 0.08× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-184.0M | $-17.5M |
| Free Cash FlowOCF − Capex | $-184.1M | — |
| FCF MarginFCF / Revenue | -2951.3% | — |
| Capex IntensityCapex / Revenue | 0.7% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-326.5M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-184.0M | $-17.5M | ||
| Q3 25 | $-32.5M | $8.2M | ||
| Q2 25 | $-49.0M | $7.0M | ||
| Q1 25 | $-60.8M | $6.0M | ||
| Q4 24 | $-55.0M | $2.5M | ||
| Q3 24 | $-50.7M | $5.1M | ||
| Q2 24 | $-62.8M | $2.3M | ||
| Q1 24 | $-61.3M | $9.4M |
| Q4 25 | $-184.1M | — | ||
| Q3 25 | $-32.5M | — | ||
| Q2 25 | $-49.1M | — | ||
| Q1 25 | $-60.8M | — | ||
| Q4 24 | $-55.2M | — | ||
| Q3 24 | $-50.9M | — | ||
| Q2 24 | $-63.1M | — | ||
| Q1 24 | $-61.9M | — |
| Q4 25 | -2951.3% | — | ||
| Q3 25 | -997.6% | — | ||
| Q2 25 | -623.0% | — | ||
| Q1 25 | -1655.0% | — | ||
| Q4 24 | -101.8% | — | ||
| Q3 24 | -332.1% | — | ||
| Q2 24 | -418.6% | — | ||
| Q1 24 | -389.3% | — |
| Q4 25 | 0.7% | — | ||
| Q3 25 | 0.3% | — | ||
| Q2 25 | 0.1% | — | ||
| Q1 25 | 0.5% | — | ||
| Q4 24 | 0.3% | — | ||
| Q3 24 | 1.4% | 0.0% | ||
| Q2 24 | 2.2% | — | ||
| Q1 24 | 3.4% | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
