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Side-by-side financial comparison of ALNYLAM PHARMACEUTICALS, INC. (ALNY) and PERRIGO Co plc (PRGO). Click either name above to swap in a different company.
PERRIGO Co plc is the larger business by last-quarter revenue ($1.1B vs $1.1B, roughly 1.0× ALNYLAM PHARMACEUTICALS, INC.). ALNYLAM PHARMACEUTICALS, INC. runs the higher net margin — 17.0% vs -127.8%, a 144.8% gap on every dollar of revenue. On growth, ALNYLAM PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (84.9% vs -2.5%). PERRIGO Co plc produced more free cash flow last quarter ($148.6M vs $140.3M). Over the past eight quarters, ALNYLAM PHARMACEUTICALS, INC.'s revenue compounded faster (49.0% CAGR vs 1.3%).
Alnylam Pharmaceuticals, Inc. is an American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically defined diseases. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts. In 2016, Forbes included the company on its "100 Most Innovative Growth Companies" list.
Perrigo Company plc is an American Irish-registered manufacturer of private label over-the-counter pharmaceuticals, and while 70% of Perrigo's net sales are from the U.S. healthcare system, Perrigo is legally headquartered in Ireland for tax purposes, which accounts for 0.60% of net sales. In 2013, Perrigo completed the sixth-largest US corporate tax inversion in history when it reregistered its tax status to Ireland to avoid U.S. corporate taxes. Perrigo maintains its corporate headquarters ...
ALNY vs PRGO — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $1.1B | $1.1B |
| Net Profit | $186.4M | $-1.4B |
| Gross Margin | 75.6% | 32.6% |
| Operating Margin | 12.0% | -116.0% |
| Net Margin | 17.0% | -127.8% |
| Revenue YoY | 84.9% | -2.5% |
| Net Profit YoY | 322.6% | -3093.9% |
| EPS (diluted) | $1.44 | $-10.23 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $1.1B | $1.1B | ||
| Q3 25 | $1.2B | $1.0B | ||
| Q2 25 | $773.7M | $1.1B | ||
| Q1 25 | $594.2M | $1.0B | ||
| Q4 24 | $593.2M | $1.1B | ||
| Q3 24 | $500.9M | $1.1B | ||
| Q2 24 | $659.8M | $1.1B | ||
| Q1 24 | $494.3M | $1.1B |
| Q4 25 | $186.4M | $-1.4B | ||
| Q3 25 | $251.1M | $7.5M | ||
| Q2 25 | $-66.3M | $-8.4M | ||
| Q1 25 | $-57.5M | $-6.4M | ||
| Q4 24 | $-83.8M | $-44.4M | ||
| Q3 24 | $-111.6M | $-21.0M | ||
| Q2 24 | $-16.9M | $-108.4M | ||
| Q1 24 | $-65.9M | $2.0M |
| Q4 25 | 75.6% | 32.6% | ||
| Q3 25 | 84.2% | 36.1% | ||
| Q2 25 | 81.6% | 34.4% | ||
| Q1 25 | 88.2% | 37.6% | ||
| Q4 24 | 82.7% | 33.9% | ||
| Q3 24 | 83.6% | 37.2% | ||
| Q2 24 | 89.8% | 37.0% | ||
| Q1 24 | 89.0% | 33.1% |
| Q4 25 | 12.0% | -116.0% | ||
| Q3 25 | 29.5% | 7.0% | ||
| Q2 25 | -2.1% | 4.3% | ||
| Q1 25 | 3.0% | 4.5% | ||
| Q4 24 | -17.7% | 10.0% | ||
| Q3 24 | -15.4% | 7.4% | ||
| Q2 24 | 7.4% | -2.5% | ||
| Q1 24 | -8.8% | -5.1% |
| Q4 25 | 17.0% | -127.8% | ||
| Q3 25 | 20.1% | 0.7% | ||
| Q2 25 | -8.6% | -0.8% | ||
| Q1 25 | -9.7% | -0.6% | ||
| Q4 24 | -14.1% | -3.9% | ||
| Q3 24 | -22.3% | -1.9% | ||
| Q2 24 | -2.6% | -10.2% | ||
| Q1 24 | -13.3% | 0.2% |
| Q4 25 | $1.44 | $-10.23 | ||
| Q3 25 | $1.84 | $0.05 | ||
| Q2 25 | $-0.51 | $-0.06 | ||
| Q1 25 | $-0.44 | $-0.05 | ||
| Q4 24 | $-0.66 | $-0.32 | ||
| Q3 24 | $-0.87 | $-0.15 | ||
| Q2 24 | $-0.13 | $-0.79 | ||
| Q1 24 | $-0.52 | $0.01 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $1.7B | — |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $789.2M | $2.9B |
| Total Assets | $5.0B | $8.5B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $1.7B | — | ||
| Q3 25 | $1.5B | $432.1M | ||
| Q2 25 | $1.1B | $454.2M | ||
| Q1 25 | $1.0B | $409.9M | ||
| Q4 24 | $966.4M | $558.8M | ||
| Q3 24 | $1.1B | $1.5B | ||
| Q2 24 | $968.5M | $542.8M | ||
| Q1 24 | $681.9M | $658.5M |
| Q4 25 | $789.2M | $2.9B | ||
| Q3 25 | $233.9M | $4.4B | ||
| Q2 25 | $250.6M | $4.5B | ||
| Q1 25 | $115.4M | $4.4B | ||
| Q4 24 | $67.1M | $4.3B | ||
| Q3 24 | $32.4M | $4.6B | ||
| Q2 24 | $-3.1M | $4.5B | ||
| Q1 24 | $-219.3M | $4.7B |
| Q4 25 | $5.0B | $8.5B | ||
| Q3 25 | $4.9B | $10.1B | ||
| Q2 25 | $4.6B | $10.1B | ||
| Q1 25 | $4.2B | $9.8B | ||
| Q4 24 | $4.2B | $9.6B | ||
| Q3 24 | $4.2B | $11.2B | ||
| Q2 24 | $4.0B | $10.4B | ||
| Q1 24 | $3.8B | $10.6B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $163.6M | $175.4M |
| Free Cash FlowOCF − Capex | $140.3M | $148.6M |
| FCF MarginFCF / Revenue | 12.8% | 13.4% |
| Capex IntensityCapex / Revenue | 2.1% | 2.4% |
| Cash ConversionOCF / Net Profit | 0.88× | — |
| TTM Free Cash FlowTrailing 4 quarters | $465.4M | $145.1M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $163.6M | $175.4M | ||
| Q3 25 | $325.1M | $51.7M | ||
| Q2 25 | $153.7M | $75.9M | ||
| Q1 25 | $-118.3M | $-64.5M | ||
| Q4 24 | $-94.7M | $312.6M | ||
| Q3 24 | $43.7M | $42.2M | ||
| Q2 24 | $124.2M | $9.5M | ||
| Q1 24 | $-81.5M | $-1.4M |
| Q4 25 | $140.3M | $148.6M | ||
| Q3 25 | $313.0M | $29.8M | ||
| Q2 25 | $139.4M | $56.7M | ||
| Q1 25 | $-127.3M | $-90.0M | ||
| Q4 24 | $-103.8M | $274.9M | ||
| Q3 24 | $39.5M | $15.1M | ||
| Q2 24 | $116.1M | $-18.9M | ||
| Q1 24 | $-94.5M | $-26.5M |
| Q4 25 | 12.8% | 13.4% | ||
| Q3 25 | 25.1% | 2.9% | ||
| Q2 25 | 18.0% | 5.4% | ||
| Q1 25 | -21.4% | -8.6% | ||
| Q4 24 | -17.5% | 24.2% | ||
| Q3 24 | 7.9% | 1.4% | ||
| Q2 24 | 17.6% | -1.8% | ||
| Q1 24 | -19.1% | -2.4% |
| Q4 25 | 2.1% | 2.4% | ||
| Q3 25 | 1.0% | 2.1% | ||
| Q2 25 | 1.8% | 1.8% | ||
| Q1 25 | 1.5% | 2.4% | ||
| Q4 24 | 1.5% | 3.3% | ||
| Q3 24 | 0.8% | 2.5% | ||
| Q2 24 | 1.2% | 2.7% | ||
| Q1 24 | 2.6% | 2.3% |
| Q4 25 | 0.88× | — | ||
| Q3 25 | 1.29× | 6.89× | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | -0.70× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ALNY
| TTR | $858.3M | 78% |
| Rare | $136.4M | 12% |
| GIVLAARI | $56.3M | 5% |
| Collaborative Arrangement | $40.9M | 4% |
| ONPATTRO | $12.0M | 1% |
PRGO
| Consumer Self Care Americas | $697.0M | 63% |
| Digestive Health | $123.9M | 11% |
| Nutrition | $108.3M | 10% |
| Healthy Lifestyle | $94.8M | 9% |
| Pain And Sleep Aids | $87.1M | 8% |
