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Side-by-side financial comparison of Amplitude, Inc. (AMPL) and OPKO HEALTH, INC. (OPK). Click either name above to swap in a different company.
OPKO HEALTH, INC. is the larger business by last-quarter revenue ($148.5M vs $91.4M, roughly 1.6× Amplitude, Inc.). Amplitude, Inc. runs the higher net margin — -19.3% vs -21.1%, a 1.7% gap on every dollar of revenue. On growth, Amplitude, Inc. posted the faster year-over-year revenue change (17.0% vs -19.2%). Amplitude, Inc. produced more free cash flow last quarter ($12.7M vs $-28.6M). Over the past eight quarters, Amplitude, Inc.'s revenue compounded faster (12.2% CAGR vs -7.5%).
Amplitude is an American publicly traded company that develops digital analytics software. The company was listed publicly on the Nasdaq stock exchange under the ticker symbol AMPL on September 28, 2021.
OPKO Health, Inc. is a medical test and medication company focused on diagnostics and pharmaceuticals. The company is a publicly traded company on NASDAQ and TASE under the symbol "OPK".
AMPL vs OPK — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $91.4M | $148.5M |
| Net Profit | $-17.7M | $-31.3M |
| Gross Margin | 74.6% | 43.1% |
| Operating Margin | -18.3% | -25.8% |
| Net Margin | -19.3% | -21.1% |
| Revenue YoY | 17.0% | -19.2% |
| Net Profit YoY | 45.8% | -322.8% |
| EPS (diluted) | $-0.13 | $-0.04 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $91.4M | $148.5M | ||
| Q3 25 | $88.6M | $151.7M | ||
| Q2 25 | $83.3M | $156.8M | ||
| Q1 25 | $80.0M | $150.0M | ||
| Q4 24 | $78.1M | $183.6M | ||
| Q3 24 | $75.2M | $173.6M | ||
| Q2 24 | $73.3M | $182.2M | ||
| Q1 24 | $72.6M | $173.7M |
| Q4 25 | $-17.7M | $-31.3M | ||
| Q3 25 | $-24.0M | $21.6M | ||
| Q2 25 | $-24.7M | $-148.4M | ||
| Q1 25 | $-22.2M | $-67.6M | ||
| Q4 24 | $-32.6M | $14.0M | ||
| Q3 24 | $-16.9M | $24.9M | ||
| Q2 24 | $-23.4M | $-10.3M | ||
| Q1 24 | $-21.5M | $-81.8M |
| Q4 25 | 74.6% | 43.1% | ||
| Q3 25 | 73.9% | 32.9% | ||
| Q2 25 | 72.6% | 31.5% | ||
| Q1 25 | 74.7% | 28.4% | ||
| Q4 24 | 74.7% | 46.1% | ||
| Q3 24 | 75.1% | 23.1% | ||
| Q2 24 | 73.4% | 28.4% | ||
| Q1 24 | 74.0% | 24.2% |
| Q4 25 | -18.3% | -25.8% | ||
| Q3 25 | -26.0% | 31.7% | ||
| Q2 25 | -29.0% | -38.3% | ||
| Q1 25 | -26.8% | -44.8% | ||
| Q4 24 | -41.2% | -18.0% | ||
| Q3 24 | -21.4% | 8.2% | ||
| Q2 24 | -31.7% | -33.9% | ||
| Q1 24 | -29.0% | -41.2% |
| Q4 25 | -19.3% | -21.1% | ||
| Q3 25 | -27.1% | 14.3% | ||
| Q2 25 | -29.6% | -94.7% | ||
| Q1 25 | -27.8% | -45.1% | ||
| Q4 24 | -41.7% | 7.6% | ||
| Q3 24 | -22.4% | 14.3% | ||
| Q2 24 | -31.9% | -5.7% | ||
| Q1 24 | -29.5% | -47.1% |
| Q4 25 | $-0.13 | $-0.04 | ||
| Q3 25 | $-0.18 | $0.03 | ||
| Q2 25 | $-0.19 | $-0.19 | ||
| Q1 25 | $-0.17 | $-0.10 | ||
| Q4 24 | $-0.25 | $0.02 | ||
| Q3 24 | $-0.14 | $0.03 | ||
| Q2 24 | $-0.19 | $-0.01 | ||
| Q1 24 | $-0.18 | $-0.12 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $192.0M | $364.4M |
| Total DebtLower is stronger | — | $344.0M |
| Stockholders' EquityBook value | $245.3M | $1.3B |
| Total Assets | $420.7M | $1.9B |
| Debt / EquityLower = less leverage | — | 0.27× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $192.0M | $364.4M | ||
| Q3 25 | $189.2M | $412.0M | ||
| Q2 25 | $208.1M | $267.3M | ||
| Q1 25 | $209.0M | $428.8M | ||
| Q4 24 | $241.1M | $426.6M | ||
| Q3 24 | $319.9M | $400.1M | ||
| Q2 24 | $318.3M | $40.6M | ||
| Q1 24 | $316.1M | $75.6M |
| Q4 25 | — | $344.0M | ||
| Q3 25 | — | $344.2M | ||
| Q2 25 | — | $343.3M | ||
| Q1 25 | — | $439.2M | ||
| Q4 24 | — | $437.2M | ||
| Q3 24 | — | $441.0M | ||
| Q2 24 | — | $201.9M | ||
| Q1 24 | — | $350.1M |
| Q4 25 | $245.3M | $1.3B | ||
| Q3 25 | $262.2M | $1.3B | ||
| Q2 25 | $279.5M | $1.3B | ||
| Q1 25 | $289.5M | $1.3B | ||
| Q4 24 | $296.6M | $1.4B | ||
| Q3 24 | $290.0M | $1.4B | ||
| Q2 24 | $287.3M | $1.4B | ||
| Q1 24 | $289.2M | $1.3B |
| Q4 25 | $420.7M | $1.9B | ||
| Q3 25 | $438.1M | $2.0B | ||
| Q2 25 | $456.6M | $2.0B | ||
| Q1 25 | $445.8M | $2.1B | ||
| Q4 24 | $445.9M | $2.2B | ||
| Q3 24 | $445.6M | $2.3B | ||
| Q2 24 | $445.4M | $2.0B | ||
| Q1 24 | $437.9M | $2.0B |
| Q4 25 | — | 0.27× | ||
| Q3 25 | — | 0.26× | ||
| Q2 25 | — | 0.26× | ||
| Q1 25 | — | 0.33× | ||
| Q4 24 | — | 0.32× | ||
| Q3 24 | — | 0.31× | ||
| Q2 24 | — | 0.14× | ||
| Q1 24 | — | 0.28× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $12.8M | $-25.9M |
| Free Cash FlowOCF − Capex | $12.7M | $-28.6M |
| FCF MarginFCF / Revenue | 13.8% | -19.3% |
| Capex IntensityCapex / Revenue | 0.2% | 1.8% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $28.2M | $-190.8M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $12.8M | $-25.9M | ||
| Q3 25 | $5.0M | $-34.6M | ||
| Q2 25 | $20.1M | $-83.4M | ||
| Q1 25 | $-8.0M | $-34.6M | ||
| Q4 24 | $3.2M | $-44.4M | ||
| Q3 24 | $6.2M | $-77.1M | ||
| Q2 24 | $9.2M | $-26.4M | ||
| Q1 24 | $-48.0K | $-35.6M |
| Q4 25 | $12.7M | $-28.6M | ||
| Q3 25 | $4.5M | $-37.8M | ||
| Q2 25 | $19.5M | $-86.7M | ||
| Q1 25 | $-8.5M | $-37.7M | ||
| Q4 24 | $2.4M | $-49.8M | ||
| Q3 24 | $6.2M | $-85.0M | ||
| Q2 24 | $8.6M | $-33.7M | ||
| Q1 24 | $-405.0K | $-40.0M |
| Q4 25 | 13.8% | -19.3% | ||
| Q3 25 | 5.1% | -24.9% | ||
| Q2 25 | 23.4% | -55.3% | ||
| Q1 25 | -10.6% | -25.2% | ||
| Q4 24 | 3.1% | -27.1% | ||
| Q3 24 | 8.2% | -49.0% | ||
| Q2 24 | 11.8% | -18.5% | ||
| Q1 24 | -0.6% | -23.0% |
| Q4 25 | 0.2% | 1.8% | ||
| Q3 25 | 0.5% | 2.1% | ||
| Q2 25 | 0.6% | 2.1% | ||
| Q1 25 | 0.5% | 2.1% | ||
| Q4 24 | 1.0% | 2.9% | ||
| Q3 24 | 0.0% | 4.6% | ||
| Q2 24 | 0.8% | 4.0% | ||
| Q1 24 | 0.5% | 2.6% |
| Q4 25 | — | — | ||
| Q3 25 | — | -1.60× | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | -3.17× | ||
| Q3 24 | — | -3.10× | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
AMPL
| US | $55.8M | 61% |
| International | $35.7M | 39% |
OPK
| Services | $71.1M | 48% |
| Transfer Of Intellectual Property And Other | $33.7M | 23% |
| IE | $22.1M | 15% |
| Rayaldee | $8.8M | 6% |
| Barda Agreement | $6.8M | 5% |
| MX | $6.3M | 4% |
