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Side-by-side financial comparison of Accelerant Holdings (ARX) and IONIS PHARMACEUTICALS INC (IONS). Click either name above to swap in a different company.
Accelerant Holdings is the larger business by last-quarter revenue ($267.4M vs $203.3M, roughly 1.3× IONIS PHARMACEUTICALS INC). IONIS PHARMACEUTICALS INC runs the higher net margin — -112.8% vs -511.9%, a 399.1% gap on every dollar of revenue.
Accelerant Holdings is a global specialty insurance and reinsurance technology platform that leverages advanced data analytics and risk assessment tools to support insurance carriers, managing general agents, and underwriting partners. It delivers tailored risk solutions, streamlines underwriting workflows, and serves commercial and specialty insurance segments across North America and European markets.
Ionis Pharmaceuticals, Inc. is a biotechnology company that specializes in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics. The company was founded in 1989 is based in Carlsbad, California. The company was previously known as Isis Pharmaceuticals until December 2015.
ARX vs IONS — Head-to-Head
Income Statement — Q3 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $267.4M | $203.3M |
| Net Profit | $-1.4B | $-229.4M |
| Gross Margin | — | 96.1% |
| Operating Margin | -507.7% | -105.5% |
| Net Margin | -511.9% | -112.8% |
| Revenue YoY | — | -10.3% |
| Net Profit YoY | — | -119.8% |
| EPS (diluted) | $-6.99 | $-1.35 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $203.3M | ||
| Q3 25 | $267.4M | $156.7M | ||
| Q2 25 | $219.1M | $452.0M | ||
| Q1 25 | — | $131.6M | ||
| Q4 24 | — | $226.6M | ||
| Q3 24 | — | $133.8M | ||
| Q2 24 | — | $225.3M | ||
| Q1 24 | — | $119.5M |
| Q4 25 | — | $-229.4M | ||
| Q3 25 | $-1.4B | $-128.6M | ||
| Q2 25 | $8.8M | $123.6M | ||
| Q1 25 | — | $-146.9M | ||
| Q4 24 | — | $-104.3M | ||
| Q3 24 | — | $-140.5M | ||
| Q2 24 | — | $-66.3M | ||
| Q1 24 | — | $-142.8M |
| Q4 25 | — | 96.1% | ||
| Q3 25 | — | 98.5% | ||
| Q2 25 | — | 99.1% | ||
| Q1 25 | — | 98.9% | ||
| Q4 24 | — | 98.3% | ||
| Q3 24 | — | 99.2% | ||
| Q2 24 | — | 98.2% | ||
| Q1 24 | — | 98.2% |
| Q4 25 | — | -105.5% | ||
| Q3 25 | -507.7% | -102.2% | ||
| Q2 25 | 10.2% | 30.9% | ||
| Q1 25 | — | -111.6% | ||
| Q4 24 | — | -48.9% | ||
| Q3 24 | — | -111.1% | ||
| Q2 24 | — | -29.3% | ||
| Q1 24 | — | -125.1% |
| Q4 25 | — | -112.8% | ||
| Q3 25 | -511.9% | -82.1% | ||
| Q2 25 | 4.0% | 27.3% | ||
| Q1 25 | — | -111.6% | ||
| Q4 24 | — | -46.1% | ||
| Q3 24 | — | -105.0% | ||
| Q2 24 | — | -29.4% | ||
| Q1 24 | — | -119.5% |
| Q4 25 | — | $-1.35 | ||
| Q3 25 | $-6.99 | $-0.80 | ||
| Q2 25 | $0.04 | $0.70 | ||
| Q1 25 | — | $-0.93 | ||
| Q4 24 | — | $-0.66 | ||
| Q3 24 | — | $-0.95 | ||
| Q2 24 | — | $-0.45 | ||
| Q1 24 | — | $-0.98 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $1.6B | $2.7B |
| Total DebtLower is stronger | $121.9M | $1.8B |
| Stockholders' EquityBook value | $676.1M | $489.1M |
| Total Assets | $7.9B | $3.5B |
| Debt / EquityLower = less leverage | 0.18× | 3.71× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $2.7B | ||
| Q3 25 | $1.6B | $2.2B | ||
| Q2 25 | $1.4B | $2.3B | ||
| Q1 25 | — | $2.1B | ||
| Q4 24 | — | $2.3B | ||
| Q3 24 | — | $2.5B | ||
| Q2 24 | — | $2.1B | ||
| Q1 24 | — | $2.2B |
| Q4 25 | — | $1.8B | ||
| Q3 25 | $121.9M | — | ||
| Q2 25 | $126.7M | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | $1.3B | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | — | $489.1M | ||
| Q3 25 | $676.1M | $618.0M | ||
| Q2 25 | $346.2M | $631.7M | ||
| Q1 25 | — | $475.7M | ||
| Q4 24 | — | $588.4M | ||
| Q3 24 | — | $662.5M | ||
| Q2 24 | — | $263.7M | ||
| Q1 24 | — | $296.5M |
| Q4 25 | — | $3.5B | ||
| Q3 25 | $7.9B | $3.0B | ||
| Q2 25 | $7.5B | $3.0B | ||
| Q1 25 | — | $2.8B | ||
| Q4 24 | — | $3.0B | ||
| Q3 24 | — | $3.1B | ||
| Q2 24 | — | $2.7B | ||
| Q1 24 | — | $2.8B |
| Q4 25 | — | 3.71× | ||
| Q3 25 | 0.18× | — | ||
| Q2 25 | 0.37× | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 2.13× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $73.9M | $-137.7M |
| Free Cash FlowOCF − Capex | — | $-159.0M |
| FCF MarginFCF / Revenue | — | -78.2% |
| Capex IntensityCapex / Revenue | — | 10.5% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-320.0M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $-137.7M | ||
| Q3 25 | $73.9M | $-131.4M | ||
| Q2 25 | $309.3M | $151.3M | ||
| Q1 25 | — | $-150.8M | ||
| Q4 24 | — | $-116.1M | ||
| Q3 24 | — | $-115.0M | ||
| Q2 24 | — | $-119.9M | ||
| Q1 24 | — | $-149.9M |
| Q4 25 | — | $-159.0M | ||
| Q3 25 | — | $-136.7M | ||
| Q2 25 | — | $139.0M | ||
| Q1 25 | — | $-163.4M | ||
| Q4 24 | — | $-141.6M | ||
| Q3 24 | — | $-124.0M | ||
| Q2 24 | — | $-126.1M | ||
| Q1 24 | — | $-154.4M |
| Q4 25 | — | -78.2% | ||
| Q3 25 | — | -87.2% | ||
| Q2 25 | — | 30.8% | ||
| Q1 25 | — | -124.1% | ||
| Q4 24 | — | -62.5% | ||
| Q3 24 | — | -92.7% | ||
| Q2 24 | — | -56.0% | ||
| Q1 24 | — | -129.2% |
| Q4 25 | — | 10.5% | ||
| Q3 25 | — | 3.4% | ||
| Q2 25 | — | 2.7% | ||
| Q1 25 | — | 9.6% | ||
| Q4 24 | — | 11.3% | ||
| Q3 24 | — | 6.8% | ||
| Q2 24 | — | 2.8% | ||
| Q1 24 | — | 3.8% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | 35.15× | 1.22× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ARX
| Underwriting Segment | $117.6M | 44% |
| Exchange Services Segment | $85.0M | 32% |
| Other | $64.8M | 24% |
IONS
| Products | $58.0M | 29% |
| Spinraza Royalties | $54.0M | 27% |
| Collaborative Agreement Revenue | $52.4M | 26% |
| Wainus Royalties | $16.0M | 8% |
| Wainua Joint Development Revenue | $9.6M | 5% |
| Other Commercial | $7.6M | 4% |
| Other Royalties | $5.7M | 3% |
