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Side-by-side financial comparison of AdvanSix Inc. (ASIX) and Harmony Biosciences Holdings, Inc. (HRMY). Click either name above to swap in a different company.
AdvanSix Inc. is the larger business by last-quarter revenue ($359.9M vs $243.8M, roughly 1.5× Harmony Biosciences Holdings, Inc.). Harmony Biosciences Holdings, Inc. runs the higher net margin — 9.2% vs -0.8%, a 10.0% gap on every dollar of revenue. On growth, Harmony Biosciences Holdings, Inc. posted the faster year-over-year revenue change (21.1% vs 9.4%). Harmony Biosciences Holdings, Inc. produced more free cash flow last quarter ($126.0M vs $36.1M). Over the past eight quarters, Harmony Biosciences Holdings, Inc.'s revenue compounded faster (25.6% CAGR vs 3.4%).
AdvanSix Inc. is an American chemical company that produces nylon 6 and related chemicals such as caprolactam and ammonium sulfate fertilizers. It operated as Honeywell's Resins and Chemicals division until 2016, when it was spun off as a separate company. The unit accounted for 3 percent of Honeywell's sales at the time. For 2019, revenue is estimated at $1.4 billion. The company traces its lineage to the H. W. Jayne Company, established 1884 in Frankford, Pennsylvania.
Harmony Biosciences Holdings, Inc. is a commercial-stage biopharmaceutical company focused on developing and commercializing innovative therapies for rare neurological and central nervous system disorders. Its primary market is the United States, with its core product serving patients living with narcolepsy and other sleep-related CNS conditions across adult and pediatric segments.
ASIX vs HRMY — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $359.9M | $243.8M |
| Net Profit | $-2.8M | $22.5M |
| Gross Margin | 7.6% | 71.9% |
| Operating Margin | -0.7% | 15.8% |
| Net Margin | -0.8% | 9.2% |
| Revenue YoY | 9.4% | 21.1% |
| Net Profit YoY | -892.9% | -54.6% |
| EPS (diluted) | $-0.11 | $0.38 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $359.9M | $243.8M | ||
| Q3 25 | $374.5M | $239.5M | ||
| Q2 25 | $410.0M | $200.5M | ||
| Q1 25 | $377.8M | $184.7M | ||
| Q4 24 | $329.1M | $201.3M | ||
| Q3 24 | $398.2M | $186.0M | ||
| Q2 24 | $453.5M | $172.8M | ||
| Q1 24 | $336.8M | $154.6M |
| Q4 25 | $-2.8M | $22.5M | ||
| Q3 25 | $-2.6M | $50.9M | ||
| Q2 25 | $31.4M | $39.8M | ||
| Q1 25 | $23.3M | $45.6M | ||
| Q4 24 | $352.0K | $49.5M | ||
| Q3 24 | $22.3M | $46.1M | ||
| Q2 24 | $38.9M | $11.6M | ||
| Q1 24 | $-17.4M | $38.3M |
| Q4 25 | 7.6% | 71.9% | ||
| Q3 25 | 6.8% | 75.1% | ||
| Q2 25 | 14.3% | 81.0% | ||
| Q1 25 | 14.2% | 82.7% | ||
| Q4 24 | 3.4% | 73.0% | ||
| Q3 24 | 14.4% | 77.0% | ||
| Q2 24 | 17.9% | 81.4% | ||
| Q1 24 | 0.9% | 82.2% |
| Q4 25 | -0.7% | 15.8% | ||
| Q3 25 | -0.9% | 27.3% | ||
| Q2 25 | 7.7% | 24.0% | ||
| Q1 25 | 7.7% | 30.4% | ||
| Q4 24 | -3.9% | 27.7% | ||
| Q3 24 | 7.5% | 33.2% | ||
| Q2 24 | 11.5% | 12.4% | ||
| Q1 24 | -7.0% | 33.7% |
| Q4 25 | -0.8% | 9.2% | ||
| Q3 25 | -0.7% | 21.2% | ||
| Q2 25 | 7.7% | 19.8% | ||
| Q1 25 | 6.2% | 24.7% | ||
| Q4 24 | 0.1% | 24.6% | ||
| Q3 24 | 5.6% | 24.8% | ||
| Q2 24 | 8.6% | 6.7% | ||
| Q1 24 | -5.2% | 24.8% |
| Q4 25 | $-0.11 | $0.38 | ||
| Q3 25 | $-0.10 | $0.87 | ||
| Q2 25 | $1.15 | $0.68 | ||
| Q1 25 | $0.86 | $0.78 | ||
| Q4 24 | $0.02 | $0.85 | ||
| Q3 24 | $0.82 | $0.79 | ||
| Q2 24 | $1.43 | $0.20 | ||
| Q1 24 | $-0.65 | $0.67 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $19.8M | $775.3M |
| Total DebtLower is stronger | — | $163.7M |
| Stockholders' EquityBook value | $815.2M | $870.2M |
| Total Assets | $1.7B | $1.3B |
| Debt / EquityLower = less leverage | — | 0.19× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $19.8M | $775.3M | ||
| Q3 25 | $23.7M | $672.6M | ||
| Q2 25 | $18.4M | $565.3M | ||
| Q1 25 | $8.3M | $507.0M | ||
| Q4 24 | $19.6M | $467.2M | ||
| Q3 24 | $17.3M | $410.5M | ||
| Q2 24 | $12.1M | $346.9M | ||
| Q1 24 | $20.6M | $372.4M |
| Q4 25 | — | $163.7M | ||
| Q3 25 | — | $168.5M | ||
| Q2 25 | — | $172.1M | ||
| Q1 25 | — | $175.7M | ||
| Q4 24 | — | $179.3M | ||
| Q3 24 | — | $182.8M | ||
| Q2 24 | — | $186.4M | ||
| Q1 24 | — | $190.0M |
| Q4 25 | $815.2M | $870.2M | ||
| Q3 25 | $818.2M | $835.1M | ||
| Q2 25 | $823.7M | $773.1M | ||
| Q1 25 | $794.4M | $720.5M | ||
| Q4 24 | $774.6M | $659.2M | ||
| Q3 24 | $766.4M | $596.8M | ||
| Q2 24 | $746.6M | $538.6M | ||
| Q1 24 | $713.2M | $515.4M |
| Q4 25 | $1.7B | $1.3B | ||
| Q3 25 | $1.7B | $1.2B | ||
| Q2 25 | $1.6B | $1.1B | ||
| Q1 25 | $1.6B | $1.1B | ||
| Q4 24 | $1.6B | $999.2M | ||
| Q3 24 | $1.5B | $928.1M | ||
| Q2 24 | $1.5B | $858.4M | ||
| Q1 24 | $1.5B | $847.0M |
| Q4 25 | — | 0.19× | ||
| Q3 25 | — | 0.20× | ||
| Q2 25 | — | 0.22× | ||
| Q1 25 | — | 0.24× | ||
| Q4 24 | — | 0.27× | ||
| Q3 24 | — | 0.31× | ||
| Q2 24 | — | 0.35× | ||
| Q1 24 | — | 0.37× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $63.7M | $126.2M |
| Free Cash FlowOCF − Capex | $36.1M | $126.0M |
| FCF MarginFCF / Revenue | 10.0% | 51.7% |
| Capex IntensityCapex / Revenue | 7.7% | 0.0% |
| Cash ConversionOCF / Net Profit | — | 5.61× |
| TTM Free Cash FlowTrailing 4 quarters | $6.4M | $347.9M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $63.7M | $126.2M | ||
| Q3 25 | $26.6M | $108.7M | ||
| Q2 25 | $21.1M | $79.3M | ||
| Q1 25 | $11.4M | $34.0M | ||
| Q4 24 | $64.2M | $75.6M | ||
| Q3 24 | $57.3M | $70.5M | ||
| Q2 24 | $50.2M | $42.6M | ||
| Q1 24 | $-36.2M | $31.1M |
| Q4 25 | $36.1M | $126.0M | ||
| Q3 25 | $66.0K | $108.7M | ||
| Q2 25 | $-7.2M | $79.3M | ||
| Q1 25 | $-22.6M | $33.9M | ||
| Q4 24 | $29.8M | $75.0M | ||
| Q3 24 | $26.8M | $70.5M | ||
| Q2 24 | $16.7M | $42.0M | ||
| Q1 24 | $-71.6M | $31.1M |
| Q4 25 | 10.0% | 51.7% | ||
| Q3 25 | 0.0% | 45.4% | ||
| Q2 25 | -1.7% | 39.6% | ||
| Q1 25 | -6.0% | 18.3% | ||
| Q4 24 | 9.1% | 37.3% | ||
| Q3 24 | 6.7% | 37.9% | ||
| Q2 24 | 3.7% | 24.3% | ||
| Q1 24 | -21.3% | 20.1% |
| Q4 25 | 7.7% | 0.0% | ||
| Q3 25 | 7.1% | 0.0% | ||
| Q2 25 | 6.9% | 0.0% | ||
| Q1 25 | 9.0% | 0.1% | ||
| Q4 24 | 10.4% | 0.3% | ||
| Q3 24 | 7.7% | 0.0% | ||
| Q2 24 | 7.4% | 0.4% | ||
| Q1 24 | 10.5% | 0.0% |
| Q4 25 | — | 5.61× | ||
| Q3 25 | — | 2.14× | ||
| Q2 25 | 0.67× | 1.99× | ||
| Q1 25 | 0.49× | 0.75× | ||
| Q4 24 | 182.29× | 1.53× | ||
| Q3 24 | 2.57× | 1.53× | ||
| Q2 24 | 1.29× | 3.68× | ||
| Q1 24 | — | 0.81× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
ASIX
| Plant Nutrients | $140.0M | 39% |
| Chemical Intermediates | $92.8M | 26% |
| Caprolactam | $64.4M | 18% |
| Nylon Resins | $62.8M | 17% |
HRMY
Segment breakdown not available.
