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Side-by-side financial comparison of Ascendis Pharma A/S (ASND) and CASELLA WASTE SYSTEMS INC (CWST). Click either name above to swap in a different company.

CASELLA WASTE SYSTEMS INC is the larger business by last-quarter revenue ($469.1M vs $267.3M, roughly 1.8× Ascendis Pharma A/S). On growth, Ascendis Pharma A/S posted the faster year-over-year revenue change (42.3% vs 9.7%). Over the past eight quarters, Ascendis Pharma A/S's revenue compounded faster (60.7% CAGR vs 17.3%).

Growth hormone therapy refers to the use of growth hormone (GH) as a prescription medication—it is one form of hormone therapy. Growth hormone is a peptide hormone secreted by the pituitary gland that stimulates growth and cell reproduction. In the past, growth hormone was extracted from human pituitary glands. Growth hormone is now produced by recombinant DNA technology and is prescribed for a variety of reasons. GH therapy has been a focus of social and ethical controversies for 50 years.

Casella Waste Systems, Inc. is a waste management company based in Rutland, Vermont, United States. Founded in 1975 with a single truck, Casella is a regional, vertically integrated solid waste services company. Casella provides resource management expertise and services to residential, commercial, municipal and industrial customers, primarily in the areas of solid waste collection and disposal, transfer, recycling and organics services. The company provides integrated solid waste services in...

ASND vs CWST — Head-to-Head

Bigger by revenue
CWST
CWST
1.8× larger
CWST
$469.1M
$267.3M
ASND
Growing faster (revenue YoY)
ASND
ASND
+32.6% gap
ASND
42.3%
9.7%
CWST
Faster 2-yr revenue CAGR
ASND
ASND
Annualised
ASND
60.7%
17.3%
CWST

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
ASND
ASND
CWST
CWST
Revenue
$267.3M
$469.1M
Net Profit
$-2.5M
Gross Margin
90.5%
33.3%
Operating Margin
2.5%
Net Margin
-0.5%
Revenue YoY
42.3%
9.7%
Net Profit YoY
-151.5%
EPS (diluted)
$-0.04

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ASND
ASND
CWST
CWST
Q4 25
$267.3M
$469.1M
Q3 25
$230.7M
$485.4M
Q2 25
$170.7M
$465.3M
Q1 25
$109.0M
$417.1M
Q4 24
$187.8M
$427.5M
Q3 24
$62.5M
$411.6M
Q2 24
$38.9M
$377.2M
Q1 24
$103.6M
$341.0M
Net Profit
ASND
ASND
CWST
CWST
Q4 25
$-2.5M
Q3 25
$-65.9M
$10.0M
Q2 25
$-42.0M
$5.2M
Q1 25
$-102.2M
$-4.8M
Q4 24
$4.9M
Q3 24
$-107.1M
$5.8M
Q2 24
$-118.1M
$7.0M
Q1 24
$-141.5M
$-4.1M
Gross Margin
ASND
ASND
CWST
CWST
Q4 25
90.5%
33.3%
Q3 25
89.5%
35.0%
Q2 25
80.1%
33.8%
Q1 25
82.6%
32.8%
Q4 24
91.9%
33.2%
Q3 24
80.6%
35.1%
Q2 24
68.2%
35.4%
Q1 24
92.1%
32.3%
Operating Margin
ASND
ASND
CWST
CWST
Q4 25
2.5%
Q3 25
5.1%
6.1%
Q2 25
-33.5%
4.1%
Q1 25
-103.2%
0.8%
Q4 24
4.3%
Q3 24
-167.3%
5.9%
Q2 24
-370.2%
6.1%
Q1 24
-51.2%
2.0%
Net Margin
ASND
ASND
CWST
CWST
Q4 25
-0.5%
Q3 25
-28.5%
2.1%
Q2 25
-24.6%
1.1%
Q1 25
-93.7%
-1.2%
Q4 24
1.1%
Q3 24
-171.5%
1.4%
Q2 24
-303.9%
1.9%
Q1 24
-136.6%
-1.2%
EPS (diluted)
ASND
ASND
CWST
CWST
Q4 25
$-0.04
Q3 25
$0.16
Q2 25
$0.08
Q1 25
$-0.08
Q4 24
$0.08
Q3 24
$0.10
Q2 24
$0.12
Q1 24
$-0.07

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ASND
ASND
CWST
CWST
Cash + ST InvestmentsLiquidity on hand
$665.3M
$123.8M
Total DebtLower is stronger
$1.1B
Stockholders' EquityBook value
$-175.8M
$1.6B
Total Assets
$1.4B
$3.3B
Debt / EquityLower = less leverage
0.72×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ASND
ASND
CWST
CWST
Q4 25
$665.3M
$123.8M
Q3 25
$582.2M
$192.7M
Q2 25
$533.6M
$217.8M
Q1 25
$559.4M
$267.7M
Q4 24
$604.3M
$358.3M
Q3 24
$675.6M
$519.0M
Q2 24
$279.4M
$208.5M
Q1 24
$345.9M
$189.5M
Total Debt
ASND
ASND
CWST
CWST
Q4 25
$1.1B
Q3 25
$1.1B
Q2 25
$1.1B
Q1 25
$1.1B
Q4 24
$1.1B
Q3 24
$1.0B
Q2 24
$976.6M
Q1 24
$980.9M
Stockholders' Equity
ASND
ASND
CWST
CWST
Q4 25
$-175.8M
$1.6B
Q3 25
$-188.0M
$1.6B
Q2 25
$-202.6M
$1.6B
Q1 25
$-205.0M
$1.5B
Q4 24
$-114.2M
$1.6B
Q3 24
$-105.1M
$1.5B
Q2 24
$-346.8M
$1.0B
Q1 24
$-257.2M
$1.0B
Total Assets
ASND
ASND
CWST
CWST
Q4 25
$1.4B
$3.3B
Q3 25
$1.2B
$3.3B
Q2 25
$1.2B
$3.3B
Q1 25
$1.1B
$3.2B
Q4 24
$1.3B
$3.2B
Q3 24
$1.2B
$3.1B
Q2 24
$819.0M
$2.5B
Q1 24
$866.7M
$2.5B
Debt / Equity
ASND
ASND
CWST
CWST
Q4 25
0.72×
Q3 25
0.72×
Q2 25
0.72×
Q1 25
0.72×
Q4 24
0.70×
Q3 24
0.68×
Q2 24
0.94×
Q1 24
0.96×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ASND
ASND
CWST
CWST
Operating Cash FlowLast quarter
$58.2M
$96.6M
Free Cash FlowOCF − Capex
$39.3M
FCF MarginFCF / Revenue
8.4%
Capex IntensityCapex / Revenue
12.2%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$84.7M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ASND
ASND
CWST
CWST
Q4 25
$58.2M
$96.6M
Q3 25
$93.6M
Q2 25
$89.5M
Q1 25
$-15.5M
$50.1M
Q4 24
$-330.7M
$109.8M
Q3 24
$91.8M
Q2 24
$72.1M
Q1 24
$-109.7M
$7.7M
Free Cash Flow
ASND
ASND
CWST
CWST
Q4 25
$39.3M
Q3 25
$27.6M
Q2 25
$23.1M
Q1 25
$-5.4M
Q4 24
$32.9M
Q3 24
$40.4M
Q2 24
$27.5M
Q1 24
$-22.6M
FCF Margin
ASND
ASND
CWST
CWST
Q4 25
8.4%
Q3 25
5.7%
Q2 25
5.0%
Q1 25
-1.3%
Q4 24
7.7%
Q3 24
9.8%
Q2 24
7.3%
Q1 24
-6.6%
Capex Intensity
ASND
ASND
CWST
CWST
Q4 25
12.2%
Q3 25
13.6%
Q2 25
14.3%
Q1 25
13.3%
Q4 24
18.0%
Q3 24
12.5%
Q2 24
11.8%
Q1 24
8.9%
Cash Conversion
ASND
ASND
CWST
CWST
Q4 25
Q3 25
9.37×
Q2 25
17.19×
Q1 25
Q4 24
22.51×
Q3 24
15.91×
Q2 24
10.29×
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ASND
ASND

Segment breakdown not available.

CWST
CWST

Transferred Over Time$120.9M26%
Resource Solutions Region$92.9M20%
Collection$90.9M19%
Mid Atlantic Region$89.6M19%
National Accounts$60.9M13%
Landfill Revenue$8.3M2%
Processing Services$2.1M0%
Transportation$1.4M0%

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