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Side-by-side financial comparison of C4 Therapeutics, Inc. (CCCC) and Monte Rosa Therapeutics, Inc. (GLUE). Click either name above to swap in a different company.
Monte Rosa Therapeutics, Inc. is the larger business by last-quarter revenue ($12.8M vs $11.0M, roughly 1.2× C4 Therapeutics, Inc.). C4 Therapeutics, Inc. runs the higher net margin — -186.0% vs -212.1%, a 26.1% gap on every dollar of revenue. On growth, C4 Therapeutics, Inc. posted the faster year-over-year revenue change (112.8% vs 38.5%).
C4 Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing targeted protein degradation therapies for cancer and other severe diseases with high unmet medical needs. It leverages its proprietary TORPEDO platform to design small molecule degraders that eliminate disease-causing proteins, with a pipeline of oncology candidates in preclinical and clinical development, plus strategic partnerships with leading global pharmaceutical firms.
Monte Rosa Therapeutics is a clinical-stage biotechnology company specializing in the discovery and development of targeted molecular glue degrader therapies. Its pipeline addresses unmet medical needs across oncology, rare genetic disorders and immunological diseases, with operations focused on advancing novel treatments for global patient populations.
CCCC vs GLUE — Head-to-Head
Income Statement — Q4 FY2025 vs Q3 FY2025
| Metric | | |
|---|---|---|
| Revenue | $11.0M | $12.8M |
| Net Profit | $-20.5M | $-27.1M |
| Gross Margin | — | — |
| Operating Margin | -210.1% | -258.3% |
| Net Margin | -186.0% | -212.1% |
| Revenue YoY | 112.8% | 38.5% |
| Net Profit YoY | 40.7% | -13.5% |
| EPS (diluted) | $-0.09 | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $11.0M | — | ||
| Q3 25 | $11.2M | $12.8M | ||
| Q2 25 | $6.5M | $23.2M | ||
| Q1 25 | $7.2M | $84.9M | ||
| Q4 24 | $5.2M | $60.6M | ||
| Q3 24 | $15.4M | — | ||
| Q2 24 | $12.0M | — | ||
| Q1 24 | $3.0M | — |
| Q4 25 | $-20.5M | — | ||
| Q3 25 | $-32.2M | $-27.1M | ||
| Q2 25 | $-26.0M | $-12.3M | ||
| Q1 25 | $-26.3M | $46.9M | ||
| Q4 24 | $-34.6M | $13.4M | ||
| Q3 24 | $-24.7M | — | ||
| Q2 24 | $-17.7M | — | ||
| Q1 24 | $-28.4M | — |
| Q4 25 | -210.1% | — | ||
| Q3 25 | -306.4% | -258.3% | ||
| Q2 25 | -441.0% | -67.1% | ||
| Q1 25 | -402.9% | 51.9% | ||
| Q4 24 | -728.4% | 21.4% | ||
| Q3 24 | -183.9% | — | ||
| Q2 24 | -178.6% | — | ||
| Q1 24 | -1060.2% | — |
| Q4 25 | -186.0% | — | ||
| Q3 25 | -286.4% | -212.1% | ||
| Q2 25 | -402.6% | -53.0% | ||
| Q1 25 | -363.7% | 55.2% | ||
| Q4 24 | -667.8% | 22.2% | ||
| Q3 24 | -160.6% | — | ||
| Q2 24 | -147.6% | — | ||
| Q1 24 | -933.2% | — |
| Q4 25 | $-0.09 | — | ||
| Q3 25 | $-0.44 | — | ||
| Q2 25 | $-0.37 | — | ||
| Q1 25 | $-0.37 | — | ||
| Q4 24 | $-0.50 | — | ||
| Q3 24 | $-0.35 | — | ||
| Q2 24 | $-0.26 | — | ||
| Q1 24 | $-0.41 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $74.6M | $208.3M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $256.6M | $245.8M |
| Total Assets | $359.1M | $459.8M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $74.6M | — | ||
| Q3 25 | $58.8M | $208.3M | ||
| Q2 25 | $78.2M | $69.4M | ||
| Q1 25 | $51.3M | $78.5M | ||
| Q4 24 | $55.5M | $224.3M | ||
| Q3 24 | $59.6M | — | ||
| Q2 24 | $73.1M | — | ||
| Q1 24 | $89.7M | — |
| Q4 25 | $256.6M | — | ||
| Q3 25 | $154.4M | $245.8M | ||
| Q2 25 | $174.1M | $268.1M | ||
| Q1 25 | $195.1M | $275.2M | ||
| Q4 24 | $216.0M | $222.9M | ||
| Q3 24 | $242.7M | — | ||
| Q2 24 | $247.1M | — | ||
| Q1 24 | $258.3M | — |
| Q4 25 | $359.1M | — | ||
| Q3 25 | $265.5M | $459.8M | ||
| Q2 25 | $296.5M | $359.6M | ||
| Q1 25 | $319.5M | $393.2M | ||
| Q4 24 | $349.6M | $438.7M | ||
| Q3 24 | $376.1M | — | ||
| Q2 24 | $381.1M | — | ||
| Q1 24 | $398.4M | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-22.1M | $100.4M |
| Free Cash FlowOCF − Capex | — | $99.8M |
| FCF MarginFCF / Revenue | — | 781.5% |
| Capex IntensityCapex / Revenue | — | 5.1% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $145.0M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-22.1M | — | ||
| Q3 25 | $-31.2M | $100.4M | ||
| Q2 25 | $-12.1M | $-34.7M | ||
| Q1 25 | $-33.3M | $-45.5M | ||
| Q4 24 | $-17.9M | $128.9M | ||
| Q3 24 | $-24.1M | — | ||
| Q2 24 | $-5.0M | — | ||
| Q1 24 | $-18.1M | — |
| Q4 25 | — | — | ||
| Q3 25 | $-31.6M | $99.8M | ||
| Q2 25 | — | $-36.4M | ||
| Q1 25 | — | $-47.1M | ||
| Q4 24 | $-17.9M | $128.7M | ||
| Q3 24 | $-24.1M | — | ||
| Q2 24 | $-5.2M | — | ||
| Q1 24 | — | — |
| Q4 25 | — | — | ||
| Q3 25 | -281.5% | 781.5% | ||
| Q2 25 | — | -157.0% | ||
| Q1 25 | — | -55.4% | ||
| Q4 24 | -346.5% | 212.3% | ||
| Q3 24 | -157.2% | — | ||
| Q2 24 | -43.1% | — | ||
| Q1 24 | — | — |
| Q4 25 | — | — | ||
| Q3 25 | 3.7% | 5.1% | ||
| Q2 25 | — | 7.3% | ||
| Q1 25 | — | 1.9% | ||
| Q4 24 | 0.1% | 0.3% | ||
| Q3 24 | 0.1% | — | ||
| Q2 24 | 1.6% | — | ||
| Q1 24 | 0.0% | — |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | -0.97× | ||
| Q4 24 | — | 9.59× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
