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Side-by-side financial comparison of CareDx, Inc. (CDNA) and Guardant Health, Inc. (GH). Click either name above to swap in a different company.
Guardant Health, Inc. is the larger business by last-quarter revenue ($281.3M vs $108.4M, roughly 2.6× CareDx, Inc.). CareDx, Inc. runs the higher net margin — -3.8% vs -45.7%, a 41.9% gap on every dollar of revenue. On growth, Guardant Health, Inc. posted the faster year-over-year revenue change (39.4% vs 25.2%). Over the past eight quarters, Guardant Health, Inc.'s revenue compounded faster (29.2% CAGR vs 22.7%).
CareDx, Inc. is a leading precision medicine company dedicated to organ transplant patient care. It develops and commercializes diagnostic tests for rejection surveillance, digital health management tools, and supportive clinical services, catering to transplant clinicians, patients, and healthcare systems across North America and European core markets.
Guardant Health, Inc. is an American biotechnology company based in Palo Alto, California. Co-founders Helmy Eltoukhy and AmirAli Talasaz serve as co-chief executive officers.
CDNA vs GH — Head-to-Head
Income Statement — Q4 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $108.4M | $281.3M |
| Net Profit | $-4.1M | $-128.5M |
| Gross Margin | — | 64.6% |
| Operating Margin | -5.6% | -43.0% |
| Net Margin | -3.8% | -45.7% |
| Revenue YoY | 25.2% | 39.4% |
| Net Profit YoY | -104.7% | -15.8% |
| EPS (diluted) | $-0.08 | $-1.01 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $108.4M | $281.3M | ||
| Q3 25 | $100.1M | $265.2M | ||
| Q2 25 | $86.7M | $232.1M | ||
| Q1 25 | $84.7M | $203.5M | ||
| Q4 24 | $86.6M | $201.8M | ||
| Q3 24 | $82.9M | $191.5M | ||
| Q2 24 | $92.3M | $177.2M | ||
| Q1 24 | $72.0M | $168.5M |
| Q4 25 | $-4.1M | $-128.5M | ||
| Q3 25 | $1.7M | $-92.7M | ||
| Q2 25 | $-8.6M | $-99.9M | ||
| Q1 25 | $-10.4M | $-95.2M | ||
| Q4 24 | $87.7M | $-111.0M | ||
| Q3 24 | $-10.6M | $-107.8M | ||
| Q2 24 | $-4.6M | $-102.6M | ||
| Q1 24 | $-19.9M | $-115.0M |
| Q4 25 | — | 64.6% | ||
| Q3 25 | — | 64.7% | ||
| Q2 25 | — | 65.0% | ||
| Q1 25 | — | 63.3% | ||
| Q4 24 | — | 61.6% | ||
| Q3 24 | — | 61.1% | ||
| Q2 24 | — | 59.1% | ||
| Q1 24 | — | 61.2% |
| Q4 25 | -5.6% | -43.0% | ||
| Q3 25 | -0.2% | -37.3% | ||
| Q2 25 | -12.8% | -45.9% | ||
| Q1 25 | -15.8% | -54.6% | ||
| Q4 24 | 97.5% | -62.4% | ||
| Q3 24 | -16.6% | -61.3% | ||
| Q2 24 | -7.9% | -56.8% | ||
| Q1 24 | -31.3% | -59.2% |
| Q4 25 | -3.8% | -45.7% | ||
| Q3 25 | 1.7% | -35.0% | ||
| Q2 25 | -9.9% | -43.0% | ||
| Q1 25 | -12.2% | -46.8% | ||
| Q4 24 | 101.3% | -55.0% | ||
| Q3 24 | -12.8% | -56.3% | ||
| Q2 24 | -5.0% | -57.9% | ||
| Q1 24 | -27.6% | -68.2% |
| Q4 25 | $-0.08 | $-1.01 | ||
| Q3 25 | $0.03 | $-0.74 | ||
| Q2 25 | $-0.16 | $-0.80 | ||
| Q1 25 | $-0.19 | $-0.77 | ||
| Q4 24 | $1.60 | $-0.90 | ||
| Q3 24 | $-0.20 | $-0.88 | ||
| Q2 24 | $-0.09 | $-0.84 | ||
| Q1 24 | $-0.38 | $-0.94 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $177.2M | $378.2M |
| Total DebtLower is stronger | — | $1.5B |
| Stockholders' EquityBook value | $303.1M | $-99.3M |
| Total Assets | $413.2M | $2.0B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $177.2M | $378.2M | ||
| Q3 25 | $194.2M | $580.0M | ||
| Q2 25 | $186.3M | $629.1M | ||
| Q1 25 | $230.9M | $698.6M | ||
| Q4 24 | $260.7M | $525.5M | ||
| Q3 24 | $240.9M | $585.0M | ||
| Q2 24 | $228.9M | $933.7M | ||
| Q1 24 | $215.9M | $1.0B |
| Q4 25 | — | $1.5B | ||
| Q3 25 | — | $1.1B | ||
| Q2 25 | — | $1.1B | ||
| Q1 25 | — | $1.1B | ||
| Q4 24 | — | $1.1B | ||
| Q3 24 | $0 | — | ||
| Q2 24 | $0 | — | ||
| Q1 24 | — | — |
| Q4 25 | $303.1M | $-99.3M | ||
| Q3 25 | $311.1M | $-354.5M | ||
| Q2 25 | $327.4M | $-305.5M | ||
| Q1 25 | $379.3M | $-250.8M | ||
| Q4 24 | $378.4M | $-139.6M | ||
| Q3 24 | $273.2M | $-60.1M | ||
| Q2 24 | $264.7M | $-1.6M | ||
| Q1 24 | $256.2M | $68.3M |
| Q4 25 | $413.2M | $2.0B | ||
| Q3 25 | $432.3M | $1.3B | ||
| Q2 25 | $444.3M | $1.3B | ||
| Q1 25 | $489.6M | $1.3B | ||
| Q4 24 | $491.1M | $1.5B | ||
| Q3 24 | $477.0M | $1.5B | ||
| Q2 24 | $466.8M | $1.6B | ||
| Q1 24 | $452.4M | $1.7B |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 0.00× | — | ||
| Q2 24 | 0.00× | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $21.4M | $-26.4M |
| Free Cash FlowOCF − Capex | — | $-54.2M |
| FCF MarginFCF / Revenue | — | -19.3% |
| Capex IntensityCapex / Revenue | — | 9.9% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-233.1M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $21.4M | $-26.4M | ||
| Q3 25 | $37.4M | $-35.4M | ||
| Q2 25 | $9.9M | $-60.3M | ||
| Q1 25 | $-26.6M | $-62.7M | ||
| Q4 24 | $21.9M | $-64.5M | ||
| Q3 24 | $12.5M | $-51.1M | ||
| Q2 24 | $18.9M | $-94.0M | ||
| Q1 24 | $-15.3M | $-30.3M |
| Q4 25 | — | $-54.2M | ||
| Q3 25 | — | $-45.8M | ||
| Q2 25 | — | $-65.9M | ||
| Q1 25 | — | $-67.1M | ||
| Q4 24 | — | $-83.4M | ||
| Q3 24 | — | $-55.3M | ||
| Q2 24 | — | $-99.1M | ||
| Q1 24 | — | $-37.2M |
| Q4 25 | — | -19.3% | ||
| Q3 25 | — | -17.3% | ||
| Q2 25 | — | -28.4% | ||
| Q1 25 | — | -33.0% | ||
| Q4 24 | — | -41.3% | ||
| Q3 24 | — | -28.9% | ||
| Q2 24 | — | -55.9% | ||
| Q1 24 | — | -22.1% |
| Q4 25 | — | 9.9% | ||
| Q3 25 | — | 3.9% | ||
| Q2 25 | — | 2.4% | ||
| Q1 25 | — | 2.2% | ||
| Q4 24 | — | 9.4% | ||
| Q3 24 | — | 2.2% | ||
| Q2 24 | — | 2.9% | ||
| Q1 24 | — | 4.1% |
| Q4 25 | — | — | ||
| Q3 25 | 22.30× | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 0.25× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
CDNA
| Services | $78.4M | 72% |
| Patient And Digital Solutions | $16.8M | 15% |
| Products | $13.3M | 12% |
GH
| Oncology | $189.9M | 68% |
| Biopharma Data | $54.0M | 19% |
| Screening | $35.1M | 12% |
| Licensing Other | $2.2M | 1% |
