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Side-by-side financial comparison of Cullinan Therapeutics, Inc. (CGEM) and PROTHENA CORP PUBLIC LTD CO (PRTA). Click either name above to swap in a different company.

Cullinan Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing novel targeted oncology therapies to address unmet medical needs for patients with hard-to-treat cancers. Its core pipeline includes candidates for solid tumors and hematological malignancies, with operations and R&D partnerships spanning North America and global oncology research networks.

Prothena Corporation plc is a late-stage clinical biotechnology firm focused on developing and commercializing innovative antibody therapies for neurodegenerative disorders, rare diseases and immune-related conditions. Its core pipeline targets unmet medical needs including amyloidosis, Parkinson's and Alzheimer's, serving key markets across North America, Europe and the Asia-Pacific.

CGEM vs PRTA — Head-to-Head

Bigger by revenue
PRTA
PRTA
Infinity× larger
PRTA
$21.0K
$0
CGEM

Income Statement — Q4 FY2022 vs Q4 FY2025

Metric
CGEM
CGEM
PRTA
PRTA
Revenue
$0
$21.0K
Net Profit
$-26.8M
Gross Margin
Operating Margin
Net Margin
Revenue YoY
-99.0%
Net Profit YoY
17.6%
62.7%
EPS (diluted)
$-0.58

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
CGEM
CGEM
PRTA
PRTA
Q4 25
$21.0K
Q3 25
$2.4M
Q2 25
$4.4M
Q1 25
$2.8M
Q4 24
$2.1M
Q3 24
$970.0K
Q2 24
$132.0M
Q1 24
$50.0K
Net Profit
CGEM
CGEM
PRTA
PRTA
Q4 25
Q3 25
$-36.5M
Q2 25
$-125.8M
Q1 25
$-60.2M
Q4 24
Q3 24
$-59.0M
Q2 24
$66.9M
Q1 24
$-72.2M
Operating Margin
CGEM
CGEM
PRTA
PRTA
Q4 25
Q3 25
-1666.3%
Q2 25
-1914.4%
Q1 25
-2319.0%
Q4 24
Q3 24
-6857.0%
Q2 24
44.2%
Q1 24
-163056.0%
Net Margin
CGEM
CGEM
PRTA
PRTA
Q4 25
Q3 25
-1513.1%
Q2 25
-2845.4%
Q1 25
-2128.5%
Q4 24
Q3 24
-6082.6%
Q2 24
50.7%
Q1 24
-144478.0%
EPS (diluted)
CGEM
CGEM
PRTA
PRTA
Q4 25
Q3 25
$-0.68
Q2 25
$-2.34
Q1 25
$-1.12
Q4 24
Q3 24
$-1.10
Q2 24
$1.22
Q1 24
$-1.34

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
CGEM
CGEM
PRTA
PRTA
Cash + ST InvestmentsLiquidity on hand
$467.3M
$307.5M
Total DebtLower is stronger
Stockholders' EquityBook value
$535.0M
$280.5M
Total Assets
$561.1M
$326.8M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
CGEM
CGEM
PRTA
PRTA
Q4 25
$307.5M
Q3 25
$330.8M
Q2 25
$371.4M
Q1 25
$417.9M
Q4 24
$471.4M
Q3 24
$519.3M
Q2 24
$564.1M
Q1 24
$546.5M
Stockholders' Equity
CGEM
CGEM
PRTA
PRTA
Q4 25
$280.5M
Q3 25
$295.0M
Q2 25
$324.3M
Q1 25
$437.7M
Q4 24
$486.9M
Q3 24
$534.4M
Q2 24
$581.9M
Q1 24
$502.4M
Total Assets
CGEM
CGEM
PRTA
PRTA
Q4 25
$326.8M
Q3 25
$352.6M
Q2 25
$399.1M
Q1 25
$495.3M
Q4 24
$547.1M
Q3 24
$595.3M
Q2 24
$645.6M
Q1 24
$623.2M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
CGEM
CGEM
PRTA
PRTA
Operating Cash FlowLast quarter
$-25.0M
$-163.6M
Free Cash FlowOCF − Capex
$-25.9M
FCF MarginFCF / Revenue
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
CGEM
CGEM
PRTA
PRTA
Q4 25
$-163.6M
Q3 25
$-40.6M
Q2 25
$-46.3M
Q1 25
$-53.4M
Q4 24
$-150.1M
Q3 24
$-45.2M
Q2 24
$16.0M
Q1 24
$-73.1M
Cash Conversion
CGEM
CGEM
PRTA
PRTA
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
0.24×
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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