vs

Side-by-side financial comparison of CME Group (CME) and ILLUMINA, INC. (ILMN). Click either name above to swap in a different company.

CME Group is the larger business by last-quarter revenue ($1.9B vs $1.1B, roughly 1.7× ILLUMINA, INC.). ILLUMINA, INC. runs the higher net margin — 12.3% vs 0.1%, a 12.2% gap on every dollar of revenue. On growth, CME Group posted the faster year-over-year revenue change (14.5% vs 4.8%). Over the past eight quarters, CME Group's revenue compounded faster (10.8% CAGR vs -1.3%).

CME Group Inc. is an American financial services company based in Chicago, Illinois. It operates financial derivatives exchanges, including the Chicago Mercantile Exchange (CME), the Chicago Board of Trade (CBOT), the New York Mercantile Exchange (NYMEX), and the Commodity Exchange (COMEX). The company owns 27% of S&P Dow Jones Indices. It is the world's largest operator of financial derivatives exchanges. Its exchanges are platforms for trading in agricultural products, currencies, energy, i...

Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets, and serves more than 155 countries.

CME vs ILMN — Head-to-Head

Bigger by revenue
CME
CME
1.7× larger
CME
$1.9B
$1.1B
ILMN
Growing faster (revenue YoY)
CME
CME
+9.7% gap
CME
14.5%
4.8%
ILMN
Higher net margin
ILMN
ILMN
12.2% more per $
ILMN
12.3%
0.1%
CME
Faster 2-yr revenue CAGR
CME
CME
Annualised
CME
10.8%
-1.3%
ILMN

Income Statement — Q1 FY2026 vs Q1 FY2027

Metric
CME
CME
ILMN
ILMN
Revenue
$1.9B
$1.1B
Net Profit
$1.2M
$134.0M
Gross Margin
66.1%
Operating Margin
0.1%
19.2%
Net Margin
0.1%
12.3%
Revenue YoY
14.5%
4.8%
Net Profit YoY
20.7%
EPS (diluted)
$0.87

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
CME
CME
ILMN
ILMN
Q1 26
$1.9B
$1.1B
Q4 25
$1.6B
$1.2B
Q3 25
$1.5B
Q2 25
$1.7B
Q1 25
$1.6B
Q4 24
$1.5B
$1.1B
Q3 24
$1.6B
$1.1B
Q2 24
$1.5B
$1.1B
Net Profit
CME
CME
ILMN
ILMN
Q1 26
$1.2M
$134.0M
Q4 25
$1.2B
$334.0M
Q3 25
$908.0M
Q2 25
$1.0B
Q1 25
$956.2M
Q4 24
$874.6M
$186.0M
Q3 24
$912.8M
$705.0M
Q2 24
$883.2M
$-2.0B
Gross Margin
CME
CME
ILMN
ILMN
Q1 26
66.1%
Q4 25
65.5%
Q3 25
Q2 25
Q1 25
Q4 24
65.9%
Q3 24
69.0%
Q2 24
64.8%
Operating Margin
CME
CME
ILMN
ILMN
Q1 26
0.1%
19.2%
Q4 25
61.8%
17.4%
Q3 25
63.3%
Q2 25
66.7%
Q1 25
67.5%
Q4 24
62.1%
15.8%
Q3 24
64.6%
68.6%
Q2 24
65.3%
-147.2%
Net Margin
CME
CME
ILMN
ILMN
Q1 26
0.1%
12.3%
Q4 25
71.7%
28.8%
Q3 25
59.1%
Q2 25
60.6%
Q1 25
58.2%
Q4 24
57.3%
16.8%
Q3 24
57.6%
65.3%
Q2 24
57.6%
-178.8%
EPS (diluted)
CME
CME
ILMN
ILMN
Q1 26
$0.87
Q4 25
$3.24
$2.16
Q3 25
$2.49
Q2 25
$2.81
Q1 25
$2.62
Q4 24
$2.40
$1.16
Q3 24
$2.50
$4.42
Q2 24
$2.42
$-12.48

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
CME
CME
ILMN
ILMN
Cash + ST InvestmentsLiquidity on hand
$2.4B
$1.2B
Total DebtLower is stronger
$3.4B
Stockholders' EquityBook value
$2.7B
Total Assets
$202.0B
$6.6B
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
CME
CME
ILMN
ILMN
Q1 26
$2.4B
$1.2B
Q4 25
$4.5B
$1.6B
Q3 25
$2.6B
Q2 25
$2.1B
Q1 25
$1.5B
Q4 24
$3.0B
$93.0M
Q3 24
$2.4B
$70.0M
Q2 24
$1.9B
$74.0M
Total Debt
CME
CME
ILMN
ILMN
Q1 26
$3.4B
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
Stockholders' Equity
CME
CME
ILMN
ILMN
Q1 26
$2.7B
Q4 25
$28.7B
$2.7B
Q3 25
$28.2B
Q2 25
$27.7B
Q1 25
$27.0B
Q4 24
$26.5B
$2.4B
Q3 24
$28.2B
$2.1B
Q2 24
$27.6B
$1.4B
Total Assets
CME
CME
ILMN
ILMN
Q1 26
$202.0B
$6.6B
Q4 25
$198.4B
$6.6B
Q3 25
$187.1B
Q2 25
$179.9B
Q1 25
$157.8B
Q4 24
$137.4B
$6.3B
Q3 24
$137.8B
$6.0B
Q2 24
$123.4B
$6.1B

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
CME
CME
ILMN
ILMN
Operating Cash FlowLast quarter
$289.0M
Free Cash FlowOCF − Capex
$251.0M
FCF MarginFCF / Revenue
23.0%
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
2.16×
TTM Free Cash FlowTrailing 4 quarters
$1.1B

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
CME
CME
ILMN
ILMN
Q1 26
$289.0M
Q4 25
$1.1B
$321.0M
Q3 25
$968.1M
Q2 25
$1.1B
Q1 25
$1.1B
Q4 24
$1.0B
$364.0M
Q3 24
$1.0B
$316.0M
Q2 24
$776.9M
$80.0M
Free Cash Flow
CME
CME
ILMN
ILMN
Q1 26
$251.0M
Q4 25
$1.1B
$267.0M
Q3 25
$949.7M
Q2 25
$1.0B
Q1 25
$1.1B
Q4 24
$991.7M
$335.0M
Q3 24
$973.2M
$284.0M
Q2 24
$758.7M
$49.0M
FCF Margin
CME
CME
ILMN
ILMN
Q1 26
23.0%
Q4 25
66.8%
23.0%
Q3 25
61.8%
Q2 25
61.5%
Q1 25
67.1%
Q4 24
65.0%
30.3%
Q3 24
61.4%
26.3%
Q2 24
49.5%
4.4%
Capex Intensity
CME
CME
ILMN
ILMN
Q1 26
Q4 25
2.0%
Q3 25
1.2%
Q2 25
1.1%
Q1 25
0.9%
Q4 24
1.7%
2.6%
Q3 24
1.9%
3.0%
Q2 24
1.2%
2.8%
Cash Conversion
CME
CME
ILMN
ILMN
Q1 26
2.16×
Q4 25
0.96×
0.96×
Q3 25
1.07×
Q2 25
1.03×
Q1 25
1.17×
Q4 24
1.16×
1.96×
Q3 24
1.10×
0.45×
Q2 24
0.88×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

CME
CME

Segment breakdown not available.

ILMN
ILMN

Product revenue$917.0M84%
Service and other revenue$174.0M16%

Related Comparisons