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Side-by-side financial comparison of Day One Biopharmaceuticals, Inc. (DAWN) and Vanda Pharmaceuticals Inc. (VNDA). Click either name above to swap in a different company.
Vanda Pharmaceuticals Inc. is the larger business by last-quarter revenue ($57.2M vs $39.8M, roughly 1.4× Day One Biopharmaceuticals, Inc.). Day One Biopharmaceuticals, Inc. runs the higher net margin — -49.6% vs -246.8%, a 197.2% gap on every dollar of revenue. On growth, Vanda Pharmaceuticals Inc. posted the faster year-over-year revenue change (7.6% vs -57.6%).
Day One Biopharmaceuticals is a clinical-stage biopharmaceutical firm focused on developing targeted precision oncology therapies for pediatric and young adult patients with genetically driven cancers. It advances novel drug candidates to address unmet medical needs in underserved patient segments, operating primarily in the U.S. and partnering with global oncology research institutions.
Vanda Pharmaceuticals Inc. is a biopharmaceutical company focused on developing and commercializing innovative therapies for central nervous system disorders. Its key marketed products cover indications including sleep-wake cycle disturbances and schizophrenia, with core operations and primary sales markets concentrated in North America, catering to patient groups with significant unmet medical needs.
DAWN vs VNDA — Head-to-Head
Income Statement — Q3 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $39.8M | $57.2M |
| Net Profit | $-19.7M | $-141.2M |
| Gross Margin | — | — |
| Operating Margin | -60.9% | -70.5% |
| Net Margin | -49.6% | -246.8% |
| Revenue YoY | -57.6% | 7.6% |
| Net Profit YoY | -153.3% | -2774.3% |
| EPS (diluted) | $-0.19 | $-2.40 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | — | $57.2M | ||
| Q3 25 | $39.8M | $56.3M | ||
| Q2 25 | $33.9M | $52.6M | ||
| Q1 25 | $30.8M | $50.0M | ||
| Q4 24 | — | $53.2M | ||
| Q3 24 | $93.8M | $47.7M | ||
| Q2 24 | — | $50.5M | ||
| Q1 24 | $0 | $47.5M |
| Q4 25 | — | $-141.2M | ||
| Q3 25 | $-19.7M | $-22.6M | ||
| Q2 25 | $-30.3M | $-27.2M | ||
| Q1 25 | $-36.0M | $-29.5M | ||
| Q4 24 | — | $-4.9M | ||
| Q3 24 | $37.0M | $-5.3M | ||
| Q2 24 | — | $-4.5M | ||
| Q1 24 | $-62.4M | $-4.1M |
| Q4 25 | — | -70.5% | ||
| Q3 25 | -60.9% | -55.6% | ||
| Q2 25 | -103.1% | -73.2% | ||
| Q1 25 | -133.5% | -82.0% | ||
| Q4 24 | — | -19.3% | ||
| Q3 24 | 31.6% | -23.1% | ||
| Q2 24 | — | -20.1% | ||
| Q1 24 | — | -19.5% |
| Q4 25 | — | -246.8% | ||
| Q3 25 | -49.6% | -40.1% | ||
| Q2 25 | -89.4% | -51.7% | ||
| Q1 25 | -117.0% | -58.9% | ||
| Q4 24 | — | -9.2% | ||
| Q3 24 | 39.5% | -11.2% | ||
| Q2 24 | — | -9.0% | ||
| Q1 24 | — | -8.7% |
| Q4 25 | — | $-2.40 | ||
| Q3 25 | $-0.19 | $-0.38 | ||
| Q2 25 | $-0.29 | $-0.46 | ||
| Q1 25 | $-0.35 | $-0.50 | ||
| Q4 24 | — | $-0.09 | ||
| Q3 24 | $0.38 | $-0.09 | ||
| Q2 24 | — | $-0.08 | ||
| Q1 24 | $-0.72 | $-0.07 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $451.6M | $84.9M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $450.9M | $327.2M |
| Total Assets | $513.8M | $488.9M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $84.9M | ||
| Q3 25 | $451.6M | $70.0M | ||
| Q2 25 | $453.1M | $81.0M | ||
| Q1 25 | $473.0M | $111.8M | ||
| Q4 24 | — | $102.3M | ||
| Q3 24 | $558.4M | $100.5M | ||
| Q2 24 | — | $103.0M | ||
| Q1 24 | $317.9M | $125.2M |
| Q4 25 | — | $327.2M | ||
| Q3 25 | $450.9M | $466.0M | ||
| Q2 25 | $460.8M | $486.3M | ||
| Q1 25 | $479.5M | $511.4M | ||
| Q4 24 | — | $538.5M | ||
| Q3 24 | $555.5M | $541.2M | ||
| Q2 24 | — | $542.5M | ||
| Q1 24 | $296.8M | $544.0M |
| Q4 25 | — | $488.9M | ||
| Q3 25 | $513.8M | $601.1M | ||
| Q2 25 | $519.0M | $624.7M | ||
| Q1 25 | $534.4M | $631.9M | ||
| Q4 24 | — | $656.2M | ||
| Q3 24 | $600.8M | $645.1M | ||
| Q2 24 | — | $651.4M | ||
| Q1 24 | $326.6M | $652.7M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-5.8M | $-29.4M |
| Free Cash FlowOCF − Capex | — | $-29.5M |
| FCF MarginFCF / Revenue | — | -51.6% |
| Capex IntensityCapex / Revenue | 0.0% | 0.2% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-110.4M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | — | $-29.4M | ||
| Q3 25 | $-5.8M | $-31.6M | ||
| Q2 25 | $-24.8M | $-15.3M | ||
| Q1 25 | $-59.0M | $-33.1M | ||
| Q4 24 | — | $-1.8M | ||
| Q3 24 | $50.8M | $-14.6M | ||
| Q2 24 | — | $-6.9M | ||
| Q1 24 | $-49.7M | $7.6M |
| Q4 25 | — | $-29.5M | ||
| Q3 25 | — | $-31.8M | ||
| Q2 25 | $-24.8M | $-15.6M | ||
| Q1 25 | $-59.3M | $-33.6M | ||
| Q4 24 | — | $-2.0M | ||
| Q3 24 | $50.0M | $-14.7M | ||
| Q2 24 | — | $-7.0M | ||
| Q1 24 | — | $7.6M |
| Q4 25 | — | -51.6% | ||
| Q3 25 | — | -56.5% | ||
| Q2 25 | -73.2% | -29.6% | ||
| Q1 25 | -192.8% | -67.1% | ||
| Q4 24 | — | -3.8% | ||
| Q3 24 | 53.4% | -30.9% | ||
| Q2 24 | — | -13.9% | ||
| Q1 24 | — | 15.9% |
| Q4 25 | — | 0.2% | ||
| Q3 25 | 0.0% | 0.3% | ||
| Q2 25 | 0.0% | 0.6% | ||
| Q1 25 | 1.0% | 0.9% | ||
| Q4 24 | — | 0.4% | ||
| Q3 24 | 0.8% | 0.3% | ||
| Q2 24 | — | 0.2% | ||
| Q1 24 | — | 0.0% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 1.37× | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
DAWN
| Products | $38.5M | 97% |
| License Agreement With Ipsen Pharma Sas | $1.3M | 3% |
VNDA
| Fanapt | $33.2M | 58% |
| Hetlioz | $16.4M | 29% |
| PONVORY | $7.6M | 13% |
