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Side-by-side financial comparison of Ensysce Biosciences, Inc. (ENSC) and PRECIGEN, INC. (PGEN). Click either name above to swap in a different company.

Ensysce Biosciences, Inc. is the larger business by last-quarter revenue ($1.9M vs $1.8M, roughly 1.1× PRECIGEN, INC.). Ensysce Biosciences, Inc. runs the higher net margin — -147.0% vs -1149.9%, a 1002.9% gap on every dollar of revenue. On growth, Ensysce Biosciences, Inc. posted the faster year-over-year revenue change (44.4% vs -39.3%).

Ensysce Biosciences, Inc. is a clinical-stage biotechnology firm specializing in developing innovative prodrug therapies for pain management and oncology indications. Its proprietary platform is designed to reduce opioid abuse risks while enhancing treatment efficacy, targeting global healthcare and pharmaceutical markets with a focus on unmet clinical needs.

Precigen, Inc. is an American biotechnology company. Its president and CEO is Helen Sabzevari.

ENSC vs PGEN — Head-to-Head

Bigger by revenue
ENSC
ENSC
1.1× larger
ENSC
$1.9M
$1.8M
PGEN
Growing faster (revenue YoY)
ENSC
ENSC
+83.7% gap
ENSC
44.4%
-39.3%
PGEN
Higher net margin
ENSC
ENSC
1002.9% more per $
ENSC
-147.0%
-1149.9%
PGEN

Income Statement — Q4 FY2025 vs Q2 FY2023

Metric
ENSC
ENSC
PGEN
PGEN
Revenue
$1.9M
$1.8M
Net Profit
$-2.8M
$-20.3M
Gross Margin
Operating Margin
-147.8%
-1153.6%
Net Margin
-147.0%
-1149.9%
Revenue YoY
44.4%
-39.3%
Net Profit YoY
22.3%
-15.2%
EPS (diluted)
$-0.51
$-0.08

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ENSC
ENSC
PGEN
PGEN
Q4 25
$1.9M
Q3 25
$493.1K
Q2 25
$1.4M
Q1 25
$1.3M
Q4 24
$1.3M
Q3 24
$3.4M
Q4 23
$515.0K
Q3 23
$435.4K
Net Profit
ENSC
ENSC
PGEN
PGEN
Q4 25
$-2.8M
Q3 25
$-3.7M
Q2 25
$-1.7M
Q1 25
$-1.9M
Q4 24
$-3.6M
Q3 24
$661.8K
Q4 23
$-3.5M
Q3 23
$-2.7M
Operating Margin
ENSC
ENSC
PGEN
PGEN
Q4 25
-147.8%
Q3 25
-758.7%
Q2 25
-127.6%
Q1 25
-149.1%
Q4 24
-274.3%
Q3 24
18.9%
Q4 23
-612.7%
Q3 23
-621.8%
Net Margin
ENSC
ENSC
PGEN
PGEN
Q4 25
-147.0%
Q3 25
-756.3%
Q2 25
-126.4%
Q1 25
-147.4%
Q4 24
-273.4%
Q3 24
19.4%
Q4 23
-680.4%
Q3 23
-618.0%
EPS (diluted)
ENSC
ENSC
PGEN
PGEN
Q4 25
$-0.51
Q3 25
$-1.29
Q2 25
$-0.79
Q1 25
$-1.39
Q4 24
$-0.89
Q3 24
$1.00
Q4 23
$-66.47
Q3 23
$-0.87

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ENSC
ENSC
PGEN
PGEN
Cash + ST InvestmentsLiquidity on hand
$4.3M
$88.4M
Total DebtLower is stronger
Stockholders' EquityBook value
$3.2M
$166.2M
Total Assets
$7.5M
$207.5M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ENSC
ENSC
PGEN
PGEN
Q4 25
$4.3M
Q3 25
$1.7M
Q2 25
$2.2M
Q1 25
$3.1M
Q4 24
$3.5M
Q3 24
$4.2M
Q4 23
$1.1M
Q3 23
$1.5M
Stockholders' Equity
ENSC
ENSC
PGEN
PGEN
Q4 25
$3.2M
Q3 25
$1.2M
Q2 25
$3.4M
Q1 25
$3.0M
Q4 24
$3.7M
Q3 24
$6.9M
Q4 23
$-322.9K
Q3 23
$1.5M
Total Assets
ENSC
ENSC
PGEN
PGEN
Q4 25
$7.5M
Q3 25
$3.2M
Q2 25
$5.6M
Q1 25
$4.6M
Q4 24
$5.6M
Q3 24
$9.4M
Q4 23
$2.7M
Q3 23
$3.2M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ENSC
ENSC
PGEN
PGEN
Operating Cash FlowLast quarter
$-1.5M
$-15.8M
Free Cash FlowOCF − Capex
$-15.9M
FCF MarginFCF / Revenue
-898.1%
Capex IntensityCapex / Revenue
5.7%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$-129.8M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ENSC
ENSC
PGEN
PGEN
Q4 25
$-1.5M
Q3 25
$-1.9M
Q2 25
$-2.7M
Q1 25
$-1.7M
Q4 24
$-764.1K
Q3 24
$-1.0M
Q4 23
$-1.8M
Q3 23
$-2.3M
Cash Conversion
ENSC
ENSC
PGEN
PGEN
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
Q3 24
-1.54×
Q4 23
Q3 23

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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