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Side-by-side financial comparison of FTAI Infrastructure Inc. (FIP) and IONIS PHARMACEUTICALS INC (IONS). Click either name above to swap in a different company.

IONIS PHARMACEUTICALS INC is the larger business by last-quarter revenue ($203.3M vs $143.5M, roughly 1.4× FTAI Infrastructure Inc.). FTAI Infrastructure Inc. runs the higher net margin — -68.1% vs -112.8%, a 44.7% gap on every dollar of revenue. On growth, FTAI Infrastructure Inc. posted the faster year-over-year revenue change (77.7% vs -10.3%). FTAI Infrastructure Inc. produced more free cash flow last quarter ($-68.6M vs $-159.0M). Over the past eight quarters, FTAI Infrastructure Inc.'s revenue compounded faster (31.9% CAGR vs 30.4%).

FTAI Infrastructure Inc. owns, operates and invests in high-quality critical infrastructure assets across core sectors including transportation logistics, midstream energy, and power generation. It primarily serves North American markets, focusing on assets with stable long-term cash flows, contracted revenue streams, and strong market positions to deliver sustainable returns for stakeholders.

Ionis Pharmaceuticals, Inc. is a biotechnology company that specializes in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics. The company was founded in 1989 is based in Carlsbad, California. The company was previously known as Isis Pharmaceuticals until December 2015.

FIP vs IONS — Head-to-Head

Bigger by revenue
IONS
IONS
1.4× larger
IONS
$203.3M
$143.5M
FIP
Growing faster (revenue YoY)
FIP
FIP
+88.0% gap
FIP
77.7%
-10.3%
IONS
Higher net margin
FIP
FIP
44.7% more per $
FIP
-68.1%
-112.8%
IONS
More free cash flow
FIP
FIP
$90.4M more FCF
FIP
$-68.6M
$-159.0M
IONS
Faster 2-yr revenue CAGR
FIP
FIP
Annualised
FIP
31.9%
30.4%
IONS

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
FIP
FIP
IONS
IONS
Revenue
$143.5M
$203.3M
Net Profit
$-97.7M
$-229.4M
Gross Margin
96.1%
Operating Margin
-45.7%
-105.5%
Net Margin
-68.1%
-112.8%
Revenue YoY
77.7%
-10.3%
Net Profit YoY
21.6%
-119.8%
EPS (diluted)
$-1.04
$-1.35

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
FIP
FIP
IONS
IONS
Q4 25
$143.5M
$203.3M
Q3 25
$140.6M
$156.7M
Q2 25
$122.3M
$452.0M
Q1 25
$96.2M
$131.6M
Q4 24
$80.8M
$226.6M
Q3 24
$83.3M
$133.8M
Q2 24
$84.9M
$225.3M
Q1 24
$82.5M
$119.5M
Net Profit
FIP
FIP
IONS
IONS
Q4 25
$-97.7M
$-229.4M
Q3 25
$-104.5M
$-128.6M
Q2 25
$-70.0M
$123.6M
Q1 25
$120.2M
$-146.9M
Q4 24
$-124.7M
$-104.3M
Q3 24
$-43.0M
$-140.5M
Q2 24
$-48.1M
$-66.3M
Q1 24
$-50.3M
$-142.8M
Gross Margin
FIP
FIP
IONS
IONS
Q4 25
96.1%
Q3 25
98.5%
Q2 25
99.1%
Q1 25
98.9%
Q4 24
98.3%
Q3 24
99.2%
Q2 24
98.2%
Q1 24
98.2%
Operating Margin
FIP
FIP
IONS
IONS
Q4 25
-45.7%
-105.5%
Q3 25
-70.8%
-102.2%
Q2 25
-56.4%
30.9%
Q1 25
81.8%
-111.6%
Q4 24
-152.7%
-48.9%
Q3 24
-51.7%
-111.1%
Q2 24
-56.4%
-29.3%
Q1 24
-58.8%
-125.1%
Net Margin
FIP
FIP
IONS
IONS
Q4 25
-68.1%
-112.8%
Q3 25
-74.4%
-82.1%
Q2 25
-57.2%
27.3%
Q1 25
125.0%
-111.6%
Q4 24
-154.4%
-46.1%
Q3 24
-51.6%
-105.0%
Q2 24
-56.7%
-29.4%
Q1 24
-60.9%
-119.5%
EPS (diluted)
FIP
FIP
IONS
IONS
Q4 25
$-1.04
$-1.35
Q3 25
$-1.38
$-0.80
Q2 25
$-0.73
$0.70
Q1 25
$0.89
$-0.93
Q4 24
$-1.21
$-0.66
Q3 24
$-0.45
$-0.95
Q2 24
$-0.52
$-0.45
Q1 24
$-0.54
$-0.98

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
FIP
FIP
IONS
IONS
Cash + ST InvestmentsLiquidity on hand
$57.4M
$2.7B
Total DebtLower is stronger
$3.8B
$1.8B
Stockholders' EquityBook value
$21.3M
$489.1M
Total Assets
$5.7B
$3.5B
Debt / EquityLower = less leverage
176.99×
3.71×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
FIP
FIP
IONS
IONS
Q4 25
$57.4M
$2.7B
Q3 25
$34.7M
$2.2B
Q2 25
$33.6M
$2.3B
Q1 25
$26.3M
$2.1B
Q4 24
$27.8M
$2.3B
Q3 24
$20.3M
$2.5B
Q2 24
$33.1M
$2.1B
Q1 24
$23.0M
$2.2B
Total Debt
FIP
FIP
IONS
IONS
Q4 25
$3.8B
$1.8B
Q3 25
$3.7B
Q2 25
$3.1B
Q1 25
$2.8B
Q4 24
$1.6B
$1.3B
Q3 24
$1.5B
Q2 24
$1.6B
Q1 24
$1.3B
Stockholders' Equity
FIP
FIP
IONS
IONS
Q4 25
$21.3M
$489.1M
Q3 25
$181.1M
$618.0M
Q2 25
$375.5M
$631.7M
Q1 25
$476.2M
$475.7M
Q4 24
$202.7M
$588.4M
Q3 24
$370.8M
$662.5M
Q2 24
$394.8M
$263.7M
Q1 24
$402.5M
$296.5M
Total Assets
FIP
FIP
IONS
IONS
Q4 25
$5.7B
$3.5B
Q3 25
$5.5B
$3.0B
Q2 25
$4.4B
$3.0B
Q1 25
$4.1B
$2.8B
Q4 24
$2.4B
$3.0B
Q3 24
$2.4B
$3.1B
Q2 24
$2.5B
$2.7B
Q1 24
$2.3B
$2.8B
Debt / Equity
FIP
FIP
IONS
IONS
Q4 25
176.99×
3.71×
Q3 25
20.59×
Q2 25
8.21×
Q1 25
5.79×
Q4 24
7.84×
2.13×
Q3 24
4.14×
Q2 24
3.94×
Q1 24
3.34×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
FIP
FIP
IONS
IONS
Operating Cash FlowLast quarter
$-2.8M
$-137.7M
Free Cash FlowOCF − Capex
$-68.6M
$-159.0M
FCF MarginFCF / Revenue
-47.8%
-78.2%
Capex IntensityCapex / Revenue
45.9%
10.5%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$-398.5M
$-320.0M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
FIP
FIP
IONS
IONS
Q4 25
$-2.8M
$-137.7M
Q3 25
$-24.4M
$-131.4M
Q2 25
$-5.2M
$151.3M
Q1 25
$-85.7M
$-150.8M
Q4 24
$-8.1M
$-116.1M
Q3 24
$14.2M
$-115.0M
Q2 24
$-17.6M
$-119.9M
Q1 24
$-3.9M
$-149.9M
Free Cash Flow
FIP
FIP
IONS
IONS
Q4 25
$-68.6M
$-159.0M
Q3 25
$-90.7M
$-136.7M
Q2 25
$-87.5M
$139.0M
Q1 25
$-151.7M
$-163.4M
Q4 24
$-34.3M
$-141.6M
Q3 24
$-11.7M
$-124.0M
Q2 24
$-32.1M
$-126.1M
Q1 24
$-16.7M
$-154.4M
FCF Margin
FIP
FIP
IONS
IONS
Q4 25
-47.8%
-78.2%
Q3 25
-64.5%
-87.2%
Q2 25
-71.6%
30.8%
Q1 25
-157.7%
-124.1%
Q4 24
-42.4%
-62.5%
Q3 24
-14.0%
-92.7%
Q2 24
-37.9%
-56.0%
Q1 24
-20.3%
-129.2%
Capex Intensity
FIP
FIP
IONS
IONS
Q4 25
45.9%
10.5%
Q3 25
47.2%
3.4%
Q2 25
67.3%
2.7%
Q1 25
68.6%
9.6%
Q4 24
32.5%
11.3%
Q3 24
31.1%
6.8%
Q2 24
17.2%
2.8%
Q1 24
15.6%
3.8%
Cash Conversion
FIP
FIP
IONS
IONS
Q4 25
Q3 25
Q2 25
1.22×
Q1 25
-0.71×
Q4 24
Q3 24
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

FIP
FIP

Power Revenues$45.9M32%
Rail Revenue$44.6M31%
Service Other$22.8M16%
Gas Revenues$15.3M11%
Roadside Services Revenues$11.5M8%
Rapauno$1.2M1%

IONS
IONS

Products$58.0M29%
Spinraza Royalties$54.0M27%
Collaborative Agreement Revenue$52.4M26%
Wainus Royalties$16.0M8%
Wainua Joint Development Revenue$9.6M5%
Other Commercial$7.6M4%
Other Royalties$5.7M3%

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