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Side-by-side financial comparison of FINANCIAL INSTITUTIONS INC (FISI) and RHYTHM PHARMACEUTICALS, INC. (RYTM). Click either name above to swap in a different company.
FINANCIAL INSTITUTIONS INC is the larger business by last-quarter revenue ($62.7M vs $57.3M, roughly 1.1× RHYTHM PHARMACEUTICALS, INC.). FINANCIAL INSTITUTIONS INC runs the higher net margin — 33.5% vs -83.0%, a 116.5% gap on every dollar of revenue. Over the past eight quarters, RHYTHM PHARMACEUTICALS, INC.'s revenue compounded faster (48.5% CAGR vs -2.0%).
The Mizuho Financial Group, Inc. , known from 2000 to 2003 as Mizuho Holdings and abbreviated as MHFG or simply Mizuho, is a Japanese banking holding company headquartered in the Ōtemachi district of Chiyoda, Tokyo, Japan. The group was formed in 2000–2002 by merger of Dai-Ichi Kangyo Bank, Fuji Bank, and Industrial Bank of Japan. The name mizuho (瑞穂) literally means "abundant rice" in Japanese and "harvest" in the figurative sense.
Rhythm Pharmaceuticals is a biopharmaceutical firm focused on developing and commercializing targeted therapies for rare genetic disorders causing severe unmanageable obesity, including POMC deficiency, LEPR deficiency, and Bardet-Biedl syndrome. It serves patients in North America and Europe who lack effective standard treatments for their chronic life-altering conditions.
FISI vs RYTM — Head-to-Head
Income Statement — Q1 FY2026 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $62.7M | $57.3M |
| Net Profit | $21.0M | $-47.5M |
| Gross Margin | — | 91.6% |
| Operating Margin | — | -82.2% |
| Net Margin | 33.5% | -83.0% |
| Revenue YoY | — | 36.9% |
| Net Profit YoY | 24.3% | -9.6% |
| EPS (diluted) | $1.04 | $-0.73 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | $62.7M | — | ||
| Q4 25 | $64.1M | $57.3M | ||
| Q3 25 | $63.8M | $51.3M | ||
| Q2 25 | $59.7M | $48.5M | ||
| Q1 25 | $57.2M | $32.7M | ||
| Q4 24 | $41.6M | $41.8M | ||
| Q3 24 | $50.1M | $33.3M | ||
| Q2 24 | $65.2M | $29.1M |
| Q1 26 | $21.0M | — | ||
| Q4 25 | $20.0M | $-47.5M | ||
| Q3 25 | $20.5M | $-52.9M | ||
| Q2 25 | $17.5M | $-46.6M | ||
| Q1 25 | $16.9M | $-49.5M | ||
| Q4 24 | $-82.8M | $-43.3M | ||
| Q3 24 | $13.5M | $-43.6M | ||
| Q2 24 | $25.6M | $-32.3M |
| Q1 26 | — | — | ||
| Q4 25 | — | 91.6% | ||
| Q3 25 | — | 89.3% | ||
| Q2 25 | — | 88.6% | ||
| Q1 25 | — | 88.8% | ||
| Q4 24 | — | 90.9% | ||
| Q3 24 | — | 88.5% | ||
| Q2 24 | — | 89.9% |
| Q1 26 | — | — | ||
| Q4 25 | 37.4% | -82.2% | ||
| Q3 25 | 39.5% | -102.6% | ||
| Q2 25 | 36.0% | -93.4% | ||
| Q1 25 | 36.0% | -143.7% | ||
| Q4 24 | -276.9% | -98.6% | ||
| Q3 24 | 29.0% | -132.0% | ||
| Q2 24 | 46.2% | -139.2% |
| Q1 26 | 33.5% | — | ||
| Q4 25 | 38.3% | -83.0% | ||
| Q3 25 | 32.1% | -103.1% | ||
| Q2 25 | 29.3% | -96.1% | ||
| Q1 25 | 29.5% | -151.4% | ||
| Q4 24 | -198.9% | -103.6% | ||
| Q3 24 | 26.9% | -131.2% | ||
| Q2 24 | 39.3% | -110.9% |
| Q1 26 | $1.04 | — | ||
| Q4 25 | $0.96 | $-0.73 | ||
| Q3 25 | $0.99 | $-0.82 | ||
| Q2 25 | $0.85 | $-0.75 | ||
| Q1 25 | $0.81 | $-0.81 | ||
| Q4 24 | $-5.32 | $-0.71 | ||
| Q3 24 | $0.84 | $-0.73 | ||
| Q2 24 | $1.62 | $-0.55 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $85.5M | $388.9M |
| Total DebtLower is stronger | $114.0M | — |
| Stockholders' EquityBook value | — | $139.1M |
| Total Assets | $6.3B | $480.2M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | $85.5M | — | ||
| Q4 25 | $108.8M | $388.9M | ||
| Q3 25 | $185.9M | $416.1M | ||
| Q2 25 | $93.0M | $291.0M | ||
| Q1 25 | $167.4M | $314.5M | ||
| Q4 24 | $87.3M | $320.6M | ||
| Q3 24 | — | $298.4M | ||
| Q2 24 | — | $319.1M |
| Q1 26 | $114.0M | — | ||
| Q4 25 | $193.7M | — | ||
| Q3 25 | $115.0M | — | ||
| Q2 25 | $115.0M | — | ||
| Q1 25 | $124.9M | — | ||
| Q4 24 | $124.8M | — | ||
| Q3 24 | $124.8M | — | ||
| Q2 24 | $124.7M | — |
| Q1 26 | — | — | ||
| Q4 25 | $628.9M | $139.1M | ||
| Q3 25 | $621.7M | $148.8M | ||
| Q2 25 | $601.7M | $-11.9M | ||
| Q1 25 | $589.9M | $18.9M | ||
| Q4 24 | $569.0M | $21.7M | ||
| Q3 24 | $500.3M | $11.2M | ||
| Q2 24 | $467.7M | $39.3M |
| Q1 26 | $6.3B | — | ||
| Q4 25 | $6.3B | $480.2M | ||
| Q3 25 | $6.3B | $506.9M | ||
| Q2 25 | $6.1B | $372.7M | ||
| Q1 25 | $6.3B | $386.7M | ||
| Q4 24 | $6.1B | $392.3M | ||
| Q3 24 | $6.2B | $363.6M | ||
| Q2 24 | $6.1B | $381.8M |
| Q1 26 | — | — | ||
| Q4 25 | 0.31× | — | ||
| Q3 25 | 0.18× | — | ||
| Q2 25 | 0.19× | — | ||
| Q1 25 | 0.21× | — | ||
| Q4 24 | 0.22× | — | ||
| Q3 24 | 0.25× | — | ||
| Q2 24 | 0.27× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | — | $-25.4M |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | — | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $18.8M | $-25.4M | ||
| Q3 25 | $-6.9M | $-26.6M | ||
| Q2 25 | $-5.7M | $-23.3M | ||
| Q1 25 | $10.0M | $-40.4M | ||
| Q4 24 | $77.1M | $-18.8M | ||
| Q3 24 | $2.1M | $-25.2M | ||
| Q2 24 | $35.7M | $-29.1M |
| Q1 26 | — | — | ||
| Q4 25 | $13.3M | — | ||
| Q3 25 | $-7.9M | — | ||
| Q2 25 | $-7.3M | — | ||
| Q1 25 | $9.2M | — | ||
| Q4 24 | $72.2M | — | ||
| Q3 24 | $-299.0K | — | ||
| Q2 24 | $34.7M | — |
| Q1 26 | — | — | ||
| Q4 25 | 20.7% | — | ||
| Q3 25 | -12.4% | — | ||
| Q2 25 | -12.3% | — | ||
| Q1 25 | 16.1% | — | ||
| Q4 24 | 173.3% | — | ||
| Q3 24 | -0.6% | — | ||
| Q2 24 | 53.3% | — |
| Q1 26 | — | — | ||
| Q4 25 | 8.7% | — | ||
| Q3 25 | 1.6% | — | ||
| Q2 25 | 2.7% | — | ||
| Q1 25 | 1.4% | — | ||
| Q4 24 | 11.9% | — | ||
| Q3 24 | 4.9% | — | ||
| Q2 24 | 1.5% | — |
| Q1 26 | — | — | ||
| Q4 25 | 0.94× | — | ||
| Q3 25 | -0.34× | — | ||
| Q2 25 | -0.33× | — | ||
| Q1 25 | 0.59× | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 0.16× | — | ||
| Q2 24 | 1.39× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
FISI
| Net Interest Income | $52.0M | 83% |
| Noninterest Income | $10.7M | 17% |
RYTM
Segment breakdown not available.
