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Side-by-side financial comparison of AMICUS THERAPEUTICS, INC. (FOLD) and Safehold Inc. (SAFE). Click either name above to swap in a different company.
AMICUS THERAPEUTICS, INC. is the larger business by last-quarter revenue ($185.2M vs $97.9M, roughly 1.9× Safehold Inc.). Safehold Inc. runs the higher net margin — 28.5% vs 0.9%, a 27.6% gap on every dollar of revenue. On growth, AMICUS THERAPEUTICS, INC. posted the faster year-over-year revenue change (23.7% vs 6.5%). Over the past eight quarters, AMICUS THERAPEUTICS, INC.'s revenue compounded faster (29.5% CAGR vs 2.5%).
Amicus Therapeutics, Inc. is a public American biopharmaceutical company based in Philadelphia, Pennsylvania. The company went public in 2007 under the Nasdaq trading symbol FOLD. This followed a 2006 planned offering and subsequent withdrawal, which would have established the trading symbol as AMTX Prior to their IPO, Amicus was funded by a variety of venture capital firms including Radius Ventures, Canaan Partners and New Enterprise Associates.
SAFE Investment Company Limited is a Chinese sovereign wealth fund based in Hong Kong.
FOLD vs SAFE — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $185.2M | $97.9M |
| Net Profit | $1.7M | $27.9M |
| Gross Margin | 85.7% | 98.6% |
| Operating Margin | 8.6% | 27.4% |
| Net Margin | 0.9% | 28.5% |
| Revenue YoY | 23.7% | 6.5% |
| Net Profit YoY | -88.5% | 7.1% |
| EPS (diluted) | $0.00 | $0.38 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $185.2M | $97.9M | ||
| Q3 25 | $169.1M | $96.2M | ||
| Q2 25 | $154.7M | $93.8M | ||
| Q1 25 | $125.2M | $97.7M | ||
| Q4 24 | $149.7M | $91.9M | ||
| Q3 24 | $141.5M | $90.7M | ||
| Q2 24 | $126.7M | $89.9M | ||
| Q1 24 | $110.4M | $93.2M |
| Q4 25 | $1.7M | $27.9M | ||
| Q3 25 | $17.3M | $29.3M | ||
| Q2 25 | $-24.4M | $27.9M | ||
| Q1 25 | $-21.7M | $29.4M | ||
| Q4 24 | $14.7M | $26.0M | ||
| Q3 24 | $-6.7M | $19.3M | ||
| Q2 24 | $-15.7M | $29.7M | ||
| Q1 24 | $-48.4M | $30.7M |
| Q4 25 | 85.7% | 98.6% | ||
| Q3 25 | 88.5% | 98.5% | ||
| Q2 25 | 90.2% | 99.1% | ||
| Q1 25 | 90.7% | 98.8% | ||
| Q4 24 | 90.1% | 98.8% | ||
| Q3 24 | 90.6% | 98.8% | ||
| Q2 24 | 91.1% | 98.8% | ||
| Q1 24 | 87.7% | 98.8% |
| Q4 25 | 8.6% | 27.4% | ||
| Q3 25 | 20.3% | 25.9% | ||
| Q2 25 | -6.1% | 25.5% | ||
| Q1 25 | -6.3% | 25.9% | ||
| Q4 24 | 10.7% | 24.6% | ||
| Q3 24 | 15.3% | 17.5% | ||
| Q2 24 | 11.8% | 26.7% | ||
| Q1 24 | -25.1% | 26.4% |
| Q4 25 | 0.9% | 28.5% | ||
| Q3 25 | 10.2% | 30.5% | ||
| Q2 25 | -15.8% | 29.8% | ||
| Q1 25 | -17.3% | 30.1% | ||
| Q4 24 | 9.8% | 28.3% | ||
| Q3 24 | -4.8% | 21.3% | ||
| Q2 24 | -12.4% | 33.0% | ||
| Q1 24 | -43.9% | 33.0% |
| Q4 25 | $0.00 | $0.38 | ||
| Q3 25 | $0.06 | $0.41 | ||
| Q2 25 | $-0.08 | $0.39 | ||
| Q1 25 | $-0.07 | $0.41 | ||
| Q4 24 | $0.05 | $0.36 | ||
| Q3 24 | $-0.02 | $0.27 | ||
| Q2 24 | $-0.05 | $0.42 | ||
| Q1 24 | $-0.16 | $0.43 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $293.5M | $21.7M |
| Total DebtLower is stronger | $392.7M | $4.6B |
| Stockholders' EquityBook value | $274.2M | $2.4B |
| Total Assets | $949.9M | $7.2B |
| Debt / EquityLower = less leverage | 1.43× | 1.90× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $293.5M | $21.7M | ||
| Q3 25 | $263.8M | $12.1M | ||
| Q2 25 | $231.0M | $13.9M | ||
| Q1 25 | $250.6M | $17.3M | ||
| Q4 24 | $249.9M | $8.3M | ||
| Q3 24 | $249.8M | $15.6M | ||
| Q2 24 | $260.1M | $13.4M | ||
| Q1 24 | $239.6M | $11.3M |
| Q4 25 | $392.7M | $4.6B | ||
| Q3 25 | $392.0M | $4.5B | ||
| Q2 25 | $391.3M | $4.4B | ||
| Q1 25 | $390.7M | $4.3B | ||
| Q4 24 | $390.1M | $4.3B | ||
| Q3 24 | $389.5M | $4.3B | ||
| Q2 24 | $388.9M | $4.2B | ||
| Q1 24 | $388.4M | $4.1B |
| Q4 25 | $274.2M | $2.4B | ||
| Q3 25 | $230.4M | $2.4B | ||
| Q2 25 | $204.3M | $2.4B | ||
| Q1 25 | $193.6M | $2.4B | ||
| Q4 24 | $194.0M | $2.3B | ||
| Q3 24 | $178.8M | $2.3B | ||
| Q2 24 | $132.5M | $2.3B | ||
| Q1 24 | $130.7M | $2.3B |
| Q4 25 | $949.9M | $7.2B | ||
| Q3 25 | $868.8M | $7.1B | ||
| Q2 25 | $815.3M | $7.1B | ||
| Q1 25 | $789.8M | $6.9B | ||
| Q4 24 | $785.0M | $6.9B | ||
| Q3 24 | $786.6M | $6.8B | ||
| Q2 24 | $749.5M | $6.8B | ||
| Q1 24 | $721.8M | $6.7B |
| Q4 25 | 1.43× | 1.90× | ||
| Q3 25 | 1.70× | 1.89× | ||
| Q2 25 | 1.92× | 1.87× | ||
| Q1 25 | 2.02× | 1.85× | ||
| Q4 24 | 2.01× | 1.84× | ||
| Q3 24 | 2.18× | 1.88× | ||
| Q2 24 | 2.93× | 1.81× | ||
| Q1 24 | 2.97× | 1.81× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $16.3M | $47.8M |
| Free Cash FlowOCF − Capex | $16.0M | — |
| FCF MarginFCF / Revenue | 8.6% | — |
| Capex IntensityCapex / Revenue | 0.2% | — |
| Cash ConversionOCF / Net Profit | 9.62× | 1.72× |
| TTM Free Cash FlowTrailing 4 quarters | $29.8M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $16.3M | $47.8M | ||
| Q3 25 | $35.7M | $-1.4M | ||
| Q2 25 | $-26.5M | $28.0M | ||
| Q1 25 | $7.8M | $8.9M | ||
| Q4 24 | $-3.9M | $37.9M | ||
| Q3 24 | $-23.0M | $8.3M | ||
| Q2 24 | $22.7M | $24.8M | ||
| Q1 24 | $-29.7M | $-3.1M |
| Q4 25 | $16.0M | — | ||
| Q3 25 | $35.3M | — | ||
| Q2 25 | $-28.9M | — | ||
| Q1 25 | $7.5M | — | ||
| Q4 24 | $-4.2M | — | ||
| Q3 24 | $-23.3M | — | ||
| Q2 24 | $21.6M | — | ||
| Q1 24 | $-31.5M | — |
| Q4 25 | 8.6% | — | ||
| Q3 25 | 20.9% | — | ||
| Q2 25 | -18.7% | — | ||
| Q1 25 | 6.0% | — | ||
| Q4 24 | -2.8% | — | ||
| Q3 24 | -16.5% | — | ||
| Q2 24 | 17.0% | — | ||
| Q1 24 | -28.5% | — |
| Q4 25 | 0.2% | — | ||
| Q3 25 | 0.2% | — | ||
| Q2 25 | 1.6% | — | ||
| Q1 25 | 0.2% | — | ||
| Q4 24 | 0.2% | — | ||
| Q3 24 | 0.3% | — | ||
| Q2 24 | 0.9% | — | ||
| Q1 24 | 1.6% | — |
| Q4 25 | 9.62× | 1.72× | ||
| Q3 25 | 2.06× | -0.05× | ||
| Q2 25 | — | 1.00× | ||
| Q1 25 | — | 0.30× | ||
| Q4 24 | -0.27× | 1.45× | ||
| Q3 24 | — | 0.43× | ||
| Q2 24 | — | 0.83× | ||
| Q1 24 | — | -0.10× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
FOLD
| Other | $105.8M | 57% |
| Galafold | $64.8M | 35% |
| Pombiliti Opfolda | $14.6M | 8% |
SAFE
| Equity Method Investment Nonconsolidated Investee Or Group Of Investees | $60.3M | 62% |
| Other | $33.7M | 34% |
| Stabilized Properties | $3.8M | 4% |
