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Side-by-side financial comparison of AMICUS THERAPEUTICS, INC. (FOLD) and SEMrush Holdings, Inc. (SEMR). Click either name above to swap in a different company.
AMICUS THERAPEUTICS, INC. is the larger business by last-quarter revenue ($185.2M vs $117.7M, roughly 1.6× SEMrush Holdings, Inc.). AMICUS THERAPEUTICS, INC. runs the higher net margin — 0.9% vs -9.4%, a 10.3% gap on every dollar of revenue. On growth, AMICUS THERAPEUTICS, INC. posted the faster year-over-year revenue change (23.7% vs 14.6%). AMICUS THERAPEUTICS, INC. produced more free cash flow last quarter ($16.0M vs $14.8M). Over the past eight quarters, AMICUS THERAPEUTICS, INC.'s revenue compounded faster (29.5% CAGR vs 17.1%).
Amicus Therapeutics, Inc. is a public American biopharmaceutical company based in Philadelphia, Pennsylvania. The company went public in 2007 under the Nasdaq trading symbol FOLD. This followed a 2006 planned offering and subsequent withdrawal, which would have established the trading symbol as AMTX Prior to their IPO, Amicus was funded by a variety of venture capital firms including Radius Ventures, Canaan Partners and New Enterprise Associates.
Semrush Holdings, Inc. is an American public company that has a SaaS platform known as Semrush. The platform is used for keyword research, competitive analysis, site audits, backlink tracking, domain authority tracking, and online visibility insights. The keyword research tool provides various data points on each keyword. The platform also collects information about online keywords gathered from Google and Bing search engines. It was released by Boston-based company Semrush Inc, founded by Ol...
FOLD vs SEMR — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $185.2M | $117.7M |
| Net Profit | $1.7M | $-11.1M |
| Gross Margin | 85.7% | 80.4% |
| Operating Margin | 8.6% | -11.8% |
| Net Margin | 0.9% | -9.4% |
| Revenue YoY | 23.7% | 14.6% |
| Net Profit YoY | -88.5% | -431.8% |
| EPS (diluted) | $0.00 | $-0.09 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $185.2M | $117.7M | ||
| Q3 25 | $169.1M | $112.1M | ||
| Q2 25 | $154.7M | $108.9M | ||
| Q1 25 | $125.2M | $105.0M | ||
| Q4 24 | $149.7M | $102.6M | ||
| Q3 24 | $141.5M | $97.4M | ||
| Q2 24 | $126.7M | $91.0M | ||
| Q1 24 | $110.4M | $85.8M |
| Q4 25 | $1.7M | $-11.1M | ||
| Q3 25 | $17.3M | $-2.1M | ||
| Q2 25 | $-24.4M | $-6.6M | ||
| Q1 25 | $-21.7M | $849.0K | ||
| Q4 24 | $14.7M | $3.3M | ||
| Q3 24 | $-6.7M | $1.1M | ||
| Q2 24 | $-15.7M | $1.7M | ||
| Q1 24 | $-48.4M | $2.1M |
| Q4 25 | 85.7% | 80.4% | ||
| Q3 25 | 88.5% | 80.2% | ||
| Q2 25 | 90.2% | 80.6% | ||
| Q1 25 | 90.7% | 81.1% | ||
| Q4 24 | 90.1% | 81.7% | ||
| Q3 24 | 90.6% | 82.5% | ||
| Q2 24 | 91.1% | 83.6% | ||
| Q1 24 | 87.7% | 82.9% |
| Q4 25 | 8.6% | -11.8% | ||
| Q3 25 | 20.3% | -4.0% | ||
| Q2 25 | -6.1% | -4.0% | ||
| Q1 25 | -6.3% | -0.1% | ||
| Q4 24 | 10.7% | 1.7% | ||
| Q3 24 | 15.3% | 1.8% | ||
| Q2 24 | 11.8% | 3.7% | ||
| Q1 24 | -25.1% | 1.7% |
| Q4 25 | 0.9% | -9.4% | ||
| Q3 25 | 10.2% | -1.9% | ||
| Q2 25 | -15.8% | -6.0% | ||
| Q1 25 | -17.3% | 0.8% | ||
| Q4 24 | 9.8% | 3.3% | ||
| Q3 24 | -4.8% | 1.1% | ||
| Q2 24 | -12.4% | 1.8% | ||
| Q1 24 | -43.9% | 2.5% |
| Q4 25 | $0.00 | $-0.09 | ||
| Q3 25 | $0.06 | $-0.01 | ||
| Q2 25 | $-0.08 | $-0.04 | ||
| Q1 25 | $-0.07 | $0.01 | ||
| Q4 24 | $0.05 | $0.03 | ||
| Q3 24 | $-0.02 | $0.01 | ||
| Q2 24 | $-0.05 | $0.01 | ||
| Q1 24 | $-0.16 | $0.01 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $293.5M | $264.3M |
| Total DebtLower is stronger | $392.7M | — |
| Stockholders' EquityBook value | $274.2M | $288.6M |
| Total Assets | $949.9M | $454.1M |
| Debt / EquityLower = less leverage | 1.43× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $293.5M | $264.3M | ||
| Q3 25 | $263.8M | $80.8M | ||
| Q2 25 | $231.0M | $54.3M | ||
| Q1 25 | $250.6M | $64.7M | ||
| Q4 24 | $249.9M | $48.9M | ||
| Q3 24 | $249.8M | $45.1M | ||
| Q2 24 | $260.1M | $69.6M | ||
| Q1 24 | $239.6M | $41.4M |
| Q4 25 | $392.7M | — | ||
| Q3 25 | $392.0M | — | ||
| Q2 25 | $391.3M | — | ||
| Q1 25 | $390.7M | — | ||
| Q4 24 | $390.1M | — | ||
| Q3 24 | $389.5M | — | ||
| Q2 24 | $388.9M | — | ||
| Q1 24 | $388.4M | — |
| Q4 25 | $274.2M | $288.6M | ||
| Q3 25 | $230.4M | $289.7M | ||
| Q2 25 | $204.3M | $279.0M | ||
| Q1 25 | $193.6M | $268.7M | ||
| Q4 24 | $194.0M | $256.6M | ||
| Q3 24 | $178.8M | $248.5M | ||
| Q2 24 | $132.5M | $235.6M | ||
| Q1 24 | $130.7M | $226.0M |
| Q4 25 | $949.9M | $454.1M | ||
| Q3 25 | $868.8M | $450.4M | ||
| Q2 25 | $815.3M | $424.9M | ||
| Q1 25 | $789.8M | $416.5M | ||
| Q4 24 | $785.0M | $390.9M | ||
| Q3 24 | $786.6M | $383.8M | ||
| Q2 24 | $749.5M | $372.9M | ||
| Q1 24 | $721.8M | $341.7M |
| Q4 25 | 1.43× | — | ||
| Q3 25 | 1.70× | — | ||
| Q2 25 | 1.92× | — | ||
| Q1 25 | 2.02× | — | ||
| Q4 24 | 2.01× | — | ||
| Q3 24 | 2.18× | — | ||
| Q2 24 | 2.93× | — | ||
| Q1 24 | 2.97× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $16.3M | $14.9M |
| Free Cash FlowOCF − Capex | $16.0M | $14.8M |
| FCF MarginFCF / Revenue | 8.6% | 12.6% |
| Capex IntensityCapex / Revenue | 0.2% | 0.1% |
| Cash ConversionOCF / Net Profit | 9.62× | — |
| TTM Free Cash FlowTrailing 4 quarters | $29.8M | $57.8M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $16.3M | $14.9M | ||
| Q3 25 | $35.7M | $21.9M | ||
| Q2 25 | $-26.5M | $684.0K | ||
| Q1 25 | $7.8M | $22.1M | ||
| Q4 24 | $-3.9M | $11.9M | ||
| Q3 24 | $-23.0M | $8.1M | ||
| Q2 24 | $22.7M | $12.1M | ||
| Q1 24 | $-29.7M | $14.8M |
| Q4 25 | $16.0M | $14.8M | ||
| Q3 25 | $35.3M | $21.5M | ||
| Q2 25 | $-28.9M | $80.0K | ||
| Q1 25 | $7.5M | $21.4M | ||
| Q4 24 | $-4.2M | $11.5M | ||
| Q3 24 | $-23.3M | $7.6M | ||
| Q2 24 | $21.6M | $10.0M | ||
| Q1 24 | $-31.5M | $14.0M |
| Q4 25 | 8.6% | 12.6% | ||
| Q3 25 | 20.9% | 19.2% | ||
| Q2 25 | -18.7% | 0.1% | ||
| Q1 25 | 6.0% | 20.4% | ||
| Q4 24 | -2.8% | 11.2% | ||
| Q3 24 | -16.5% | 7.8% | ||
| Q2 24 | 17.0% | 11.0% | ||
| Q1 24 | -28.5% | 16.3% |
| Q4 25 | 0.2% | 0.1% | ||
| Q3 25 | 0.2% | 0.4% | ||
| Q2 25 | 1.6% | 0.6% | ||
| Q1 25 | 0.2% | 0.7% | ||
| Q4 24 | 0.2% | 0.4% | ||
| Q3 24 | 0.3% | 0.5% | ||
| Q2 24 | 0.9% | 2.4% | ||
| Q1 24 | 1.6% | 0.9% |
| Q4 25 | 9.62× | — | ||
| Q3 25 | 2.06× | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 26.04× | ||
| Q4 24 | -0.27× | 3.57× | ||
| Q3 24 | — | 7.44× | ||
| Q2 24 | — | 7.32× | ||
| Q1 24 | — | 6.91× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
FOLD
| Other | $105.8M | 57% |
| Galafold | $64.8M | 35% |
| Pombiliti Opfolda | $14.6M | 8% |
SEMR
Segment breakdown not available.
