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Side-by-side financial comparison of GRAIL, Inc. (GRAL) and OptimizeRx Corp (OPRX). Click either name above to swap in a different company.
GRAIL, Inc. is the larger business by last-quarter revenue ($43.6M vs $32.2M, roughly 1.4× OptimizeRx Corp). OptimizeRx Corp runs the higher net margin — 15.6% vs -227.5%, a 243.1% gap on every dollar of revenue. On growth, GRAIL, Inc. posted the faster year-over-year revenue change (14.0% vs -0.2%). OptimizeRx Corp produced more free cash flow last quarter ($7.1M vs $-63.9M). Over the past eight quarters, OptimizeRx Corp's revenue compounded faster (28.0% CAGR vs 27.7%).
GRAIL, Inc. is an American biotechnology company based in Menlo Park, California founded in 2015 seeking to develop an early cancer screening test for people who do not have symptoms. As a startup it was a subsidiary of Illumina, which bought it outright in 2021.
OptimizeRx CorpOPRXEarnings & Financial Report
OptimizeRx Corp is a U.S.-headquartered digital health technology company that delivers patient engagement, medication affordability and clinical communication solutions to life sciences enterprises, healthcare providers and pharmacy partners. Its core offerings include digital medication savings tools, patient support programs, and therapeutic area-specific resources to boost medication access and treatment adherence.
GRAL vs OPRX — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $43.6M | $32.2M |
| Net Profit | $-99.2M | $5.0M |
| Gross Margin | — | 74.8% |
| Operating Margin | -285.4% | 26.6% |
| Net Margin | -227.5% | 15.6% |
| Revenue YoY | 14.0% | -0.2% |
| Net Profit YoY | -2.2% | 6535.9% |
| EPS (diluted) | $-2.37 | $0.27 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $43.6M | $32.2M | ||
| Q3 25 | $36.2M | $26.1M | ||
| Q2 25 | $35.5M | $29.2M | ||
| Q1 25 | $31.8M | $21.9M | ||
| Q4 24 | $38.3M | $32.3M | ||
| Q3 24 | $28.7M | $21.3M | ||
| Q2 24 | $32.0M | $18.8M | ||
| Q1 24 | $26.7M | $19.7M |
| Q4 25 | $-99.2M | $5.0M | ||
| Q3 25 | $-89.0M | $779.0K | ||
| Q2 25 | $-114.0M | $1.5M | ||
| Q1 25 | $-106.2M | $-2.2M | ||
| Q4 24 | $-97.1M | $-78.0K | ||
| Q3 24 | $-125.7M | $-9.1M | ||
| Q2 24 | $-1.6B | $-4.0M | ||
| Q1 24 | $-218.9M | $-6.9M |
| Q4 25 | — | 74.8% | ||
| Q3 25 | — | 67.2% | ||
| Q2 25 | — | 63.8% | ||
| Q1 25 | — | 60.9% | ||
| Q4 24 | — | 68.1% | ||
| Q3 24 | — | 63.1% | ||
| Q2 24 | — | 62.2% | ||
| Q1 24 | — | 62.0% |
| Q4 25 | -285.4% | 26.6% | ||
| Q3 25 | -346.2% | 7.9% | ||
| Q2 25 | -446.9% | 10.9% | ||
| Q1 25 | -482.5% | -9.6% | ||
| Q4 24 | -358.0% | 11.2% | ||
| Q3 24 | -640.5% | -40.2% | ||
| Q2 24 | -5133.8% | -19.9% | ||
| Q1 24 | -851.1% | -25.5% |
| Q4 25 | -227.5% | 15.6% | ||
| Q3 25 | -245.8% | 3.0% | ||
| Q2 25 | -320.7% | 5.2% | ||
| Q1 25 | -333.6% | -10.0% | ||
| Q4 24 | -253.8% | -0.2% | ||
| Q3 24 | -438.7% | -42.8% | ||
| Q2 24 | -4958.8% | -21.3% | ||
| Q1 24 | -819.3% | -35.0% |
| Q4 25 | $-2.37 | $0.27 | ||
| Q3 25 | $-2.46 | $0.04 | ||
| Q2 25 | $-3.18 | $0.08 | ||
| Q1 25 | $-3.10 | $-0.12 | ||
| Q4 24 | $-1.49 | $0.00 | ||
| Q3 24 | $-3.94 | $-0.50 | ||
| Q2 24 | $-51.06 | $-0.22 | ||
| Q1 24 | $-7.05 | $-0.38 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $249.7M | $23.4M |
| Total DebtLower is stronger | — | $26.3M |
| Stockholders' EquityBook value | $2.6B | $128.3M |
| Total Assets | $2.9B | $176.9M |
| Debt / EquityLower = less leverage | — | 0.20× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $249.7M | $23.4M | ||
| Q3 25 | $126.9M | $19.5M | ||
| Q2 25 | $127.4M | $16.6M | ||
| Q1 25 | $133.9M | $16.6M | ||
| Q4 24 | $214.2M | $13.4M | ||
| Q3 24 | $853.6M | $16.1M | ||
| Q2 24 | $958.8M | — | ||
| Q1 24 | $199.7M | — |
| Q4 25 | — | $26.3M | ||
| Q3 25 | — | $28.8M | ||
| Q2 25 | — | $29.3M | ||
| Q1 25 | — | $33.8M | ||
| Q4 24 | — | $34.3M | ||
| Q3 24 | — | $36.8M | ||
| Q2 24 | — | $37.3M | ||
| Q1 24 | — | $37.8M |
| Q4 25 | $2.6B | $128.3M | ||
| Q3 25 | $2.2B | $122.3M | ||
| Q2 25 | $2.3B | $119.3M | ||
| Q1 25 | $2.4B | $116.3M | ||
| Q4 24 | $2.5B | $117.0M | ||
| Q3 24 | $2.6B | $114.5M | ||
| Q2 24 | $2.7B | $121.0M | ||
| Q1 24 | — | $122.5M |
| Q4 25 | $2.9B | $176.9M | ||
| Q3 25 | $2.6B | $170.3M | ||
| Q2 25 | $2.7B | $169.3M | ||
| Q1 25 | $2.8B | $167.8M | ||
| Q4 24 | $3.0B | $171.2M | ||
| Q3 24 | $3.1B | $165.2M | ||
| Q2 24 | $3.3B | $172.9M | ||
| Q1 24 | — | $176.4M |
| Q4 25 | — | 0.20× | ||
| Q3 25 | — | 0.24× | ||
| Q2 25 | — | 0.25× | ||
| Q1 25 | — | 0.29× | ||
| Q4 24 | — | 0.29× | ||
| Q3 24 | — | 0.32× | ||
| Q2 24 | — | 0.31× | ||
| Q1 24 | — | 0.31× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-63.8M | $7.1M |
| Free Cash FlowOCF − Capex | $-63.9M | $7.1M |
| FCF MarginFCF / Revenue | -146.5% | 22.0% |
| Capex IntensityCapex / Revenue | 0.2% | 0.0% |
| Cash ConversionOCF / Net Profit | — | 1.41× |
| TTM Free Cash FlowTrailing 4 quarters | $-299.9M | $18.7M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-63.8M | $7.1M | ||
| Q3 25 | $-63.2M | $3.2M | ||
| Q2 25 | $-77.0M | $4.6M | ||
| Q1 25 | $-95.0M | $3.9M | ||
| Q4 24 | — | $198.0K | ||
| Q3 24 | $-104.6M | $1.8M | ||
| Q2 24 | $-171.8M | $782.0K | ||
| Q1 24 | $-207.3M | $2.1M |
| Q4 25 | $-63.9M | $7.1M | ||
| Q3 25 | $-63.6M | $3.2M | ||
| Q2 25 | $-77.3M | $4.6M | ||
| Q1 25 | $-95.1M | $3.8M | ||
| Q4 24 | — | $181.0K | ||
| Q3 24 | $-105.6M | $1.8M | ||
| Q2 24 | $-173.2M | $737.0K | ||
| Q1 24 | $-209.8M | $2.1M |
| Q4 25 | -146.5% | 22.0% | ||
| Q3 25 | -175.8% | 12.2% | ||
| Q2 25 | -217.6% | 15.6% | ||
| Q1 25 | -298.6% | 17.5% | ||
| Q4 24 | — | 0.6% | ||
| Q3 24 | -368.4% | 8.3% | ||
| Q2 24 | -541.7% | 3.9% | ||
| Q1 24 | -785.3% | 10.6% |
| Q4 25 | 0.2% | 0.0% | ||
| Q3 25 | 1.1% | 0.0% | ||
| Q2 25 | 1.0% | 0.0% | ||
| Q1 25 | 0.2% | 0.1% | ||
| Q4 24 | — | 0.1% | ||
| Q3 24 | 3.4% | 0.1% | ||
| Q2 24 | 4.3% | 0.2% | ||
| Q1 24 | 9.5% | 0.2% |
| Q4 25 | — | 1.41× | ||
| Q3 25 | — | 4.11× | ||
| Q2 25 | — | 2.98× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
GRAL
| Screening Revenue | $42.3M | 97% |
| Developmental Services Revenue | $1.3M | 3% |
OPRX
Segment breakdown not available.
