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Side-by-side financial comparison of FRACTYL HEALTH, INC. (GUTS) and SERA PROGNOSTICS, INC. (SERA). Click either name above to swap in a different company.
SERA PROGNOSTICS, INC. is the larger business by last-quarter revenue ($16.0K vs $14.0K, roughly 1.1× FRACTYL HEALTH, INC.). SERA PROGNOSTICS, INC. runs the higher net margin — -48837.5% vs -165521.4%, a 116683.9% gap on every dollar of revenue. SERA PROGNOSTICS, INC. produced more free cash flow last quarter ($-6.6M vs $-18.3M).
Fractyl Health is a Burlington, Massachusetts-based healthcare company focused on metabolic diseases like obesity and type 2 diabetes. The company developed Revita, an outpatient endoscopic procedure to modify duodenal dysfunction, and Rejuva, a gene therapy platform in preclinical development to enable the pancreas to produce glucagon-like peptide-1 (GLP-1).
Sera Prognostics, Inc. is a women's health diagnostics company dedicated to developing and commercializing evidence-based clinical tests to improve pregnancy and neonatal health outcomes. Its core products include precision preterm birth risk assessment tests, serving healthcare providers, maternal health partners and patients mainly across the United States.
GUTS vs SERA — Head-to-Head
Income Statement — Q3 FY2024 vs Q3 FY2025
| Metric | | |
|---|---|---|
| Revenue | $14.0K | $16.0K |
| Net Profit | $-23.2M | $-7.8M |
| Gross Margin | 50.0% | -156.3% |
| Operating Margin | -169957.1% | -56125.0% |
| Net Margin | -165521.4% | -48837.5% |
| Revenue YoY | — | -44.8% |
| Net Profit YoY | — | 1.3% |
| EPS (diluted) | $-0.48 | $-0.16 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q3 25 | — | $16.0K | ||
| Q2 25 | — | $17.0K | ||
| Q1 25 | — | $38.0K | ||
| Q4 24 | — | $24.0K | ||
| Q3 24 | $14.0K | $29.0K | ||
| Q2 24 | $43.0K | $24.0K | ||
| Q1 24 | $33.0K | $0 | ||
| Q4 23 | — | $41.0K |
| Q3 25 | — | $-7.8M | ||
| Q2 25 | — | $-8.0M | ||
| Q1 25 | — | $-8.2M | ||
| Q4 24 | — | $-8.6M | ||
| Q3 24 | $-23.2M | $-7.9M | ||
| Q2 24 | $-17.2M | $-8.3M | ||
| Q1 24 | $-3.3M | $-8.1M | ||
| Q4 23 | — | $-7.9M |
| Q3 25 | — | -156.3% | ||
| Q2 25 | — | -141.2% | ||
| Q1 25 | — | -5.3% | ||
| Q4 24 | — | -33.3% | ||
| Q3 24 | 50.0% | 55.2% | ||
| Q2 24 | 44.2% | 16.7% | ||
| Q1 24 | 42.4% | — | ||
| Q4 23 | — | — |
| Q3 25 | — | -56125.0% | ||
| Q2 25 | — | -54823.5% | ||
| Q1 25 | — | -24342.1% | ||
| Q4 24 | — | -39262.5% | ||
| Q3 24 | -169957.1% | -30558.6% | ||
| Q2 24 | -53453.5% | -38554.2% | ||
| Q1 24 | -65278.8% | — | ||
| Q4 23 | — | -21580.5% |
| Q3 25 | — | -48837.5% | ||
| Q2 25 | — | -47329.4% | ||
| Q1 25 | — | -21544.7% | ||
| Q4 24 | — | -35745.8% | ||
| Q3 24 | -165521.4% | -27306.9% | ||
| Q2 24 | -40067.4% | -34595.8% | ||
| Q1 24 | -10066.7% | — | ||
| Q4 23 | — | -19329.3% |
| Q3 25 | — | $-0.16 | ||
| Q2 25 | — | $-0.16 | ||
| Q1 25 | — | $-0.20 | ||
| Q4 24 | — | $-0.25 | ||
| Q3 24 | $-0.48 | $-0.24 | ||
| Q2 24 | $-0.36 | $-0.25 | ||
| Q1 24 | $-0.17 | $-0.25 | ||
| Q4 23 | — | $-0.25 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $84.7M | $43.3M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $50.3M | $82.2M |
| Total Assets | $126.9M | $108.1M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q3 25 | — | $43.3M | ||
| Q2 25 | — | $40.2M | ||
| Q1 25 | — | $46.2M | ||
| Q4 24 | — | $46.2M | ||
| Q3 24 | $84.7M | $49.8M | ||
| Q2 24 | $102.4M | $50.9M | ||
| Q1 24 | $121.4M | $53.0M | ||
| Q4 23 | — | $49.1M |
| Q3 25 | — | $82.2M | ||
| Q2 25 | — | $88.2M | ||
| Q1 25 | — | $94.8M | ||
| Q4 24 | — | $47.8M | ||
| Q3 24 | $50.3M | $54.7M | ||
| Q2 24 | $70.8M | $59.8M | ||
| Q1 24 | $84.2M | $64.8M | ||
| Q4 23 | — | $70.2M |
| Q3 25 | — | $108.1M | ||
| Q2 25 | — | $111.8M | ||
| Q1 25 | — | $118.2M | ||
| Q4 24 | — | $72.6M | ||
| Q3 24 | $126.9M | $79.0M | ||
| Q2 24 | $146.4M | $84.9M | ||
| Q1 24 | $163.5M | $89.9M | ||
| Q4 23 | — | $95.4M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-18.0M | $-6.5M |
| Free Cash FlowOCF − Capex | $-18.3M | $-6.6M |
| FCF MarginFCF / Revenue | -130371.4% | -41181.3% |
| Capex IntensityCapex / Revenue | 1521.4% | 700.0% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-26.2M |
8-quarter trend — quarters aligned by calendar period.
| Q3 25 | — | $-6.5M | ||
| Q2 25 | — | $-5.5M | ||
| Q1 25 | — | $-7.6M | ||
| Q4 24 | — | $-6.3M | ||
| Q3 24 | $-18.0M | $-7.0M | ||
| Q2 24 | $-18.7M | $-5.9M | ||
| Q1 24 | $-11.7M | $5.0M | ||
| Q4 23 | — | $-6.8M |
| Q3 25 | — | $-6.6M | ||
| Q2 25 | — | $-5.8M | ||
| Q1 25 | — | $-7.6M | ||
| Q4 24 | — | $-6.3M | ||
| Q3 24 | $-18.3M | $-7.0M | ||
| Q2 24 | $-19.0M | $-5.9M | ||
| Q1 24 | $-12.8M | $5.0M | ||
| Q4 23 | — | $-6.8M |
| Q3 25 | — | -41181.3% | ||
| Q2 25 | — | -33847.1% | ||
| Q1 25 | — | -19884.2% | ||
| Q4 24 | — | -26116.7% | ||
| Q3 24 | -130371.4% | -24210.3% | ||
| Q2 24 | -44179.1% | -24729.2% | ||
| Q1 24 | -38697.0% | — | ||
| Q4 23 | — | -16539.0% |
| Q3 25 | — | 700.0% | ||
| Q2 25 | — | 1652.9% | ||
| Q1 25 | — | 7.9% | ||
| Q4 24 | — | 33.3% | ||
| Q3 24 | 1521.4% | 89.7% | ||
| Q2 24 | 604.7% | 29.2% | ||
| Q1 24 | 3209.1% | — | ||
| Q4 23 | — | 39.0% |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
