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Side-by-side financial comparison of GYRE THERAPEUTICS, INC. (GYRE) and INNOVATIVE SOLUTIONS & SUPPORT INC (ISSC). Click either name above to swap in a different company.

GYRE THERAPEUTICS, INC. is the larger business by last-quarter revenue ($37.2M vs $21.8M, roughly 1.7× INNOVATIVE SOLUTIONS & SUPPORT INC). INNOVATIVE SOLUTIONS & SUPPORT INC runs the higher net margin — 18.6% vs -3.7%, a 22.3% gap on every dollar of revenue. On growth, INNOVATIVE SOLUTIONS & SUPPORT INC posted the faster year-over-year revenue change (36.6% vs 33.4%). INNOVATIVE SOLUTIONS & SUPPORT INC produced more free cash flow last quarter ($7.0M vs $-5.8M). Over the past eight quarters, INNOVATIVE SOLUTIONS & SUPPORT INC's revenue compounded faster (42.5% CAGR vs 17.0%).

GYRE Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing novel targeted therapies for hard-to-treat hematologic malignancies and solid tumors. It focuses on precision oncology to address unmet patient needs, with operations primarily based in North America.

Motorola Solutions, Inc., is an American technology company that provides safety and security products and services. Headquartered in Chicago, Illinois, the company provides critical communications, video security, and command center technologies, used by public safety agencies and enterprises. It was formed in 2011 by the division of Motorola, Inc., and is its legal successor; the former company's mobile phone division was spun off as Motorola Mobility, now part of Chinese technology company...

GYRE vs ISSC — Head-to-Head

Bigger by revenue
GYRE
GYRE
1.7× larger
GYRE
$37.2M
$21.8M
ISSC
Growing faster (revenue YoY)
ISSC
ISSC
+3.1% gap
ISSC
36.6%
33.4%
GYRE
Higher net margin
ISSC
ISSC
22.3% more per $
ISSC
18.6%
-3.7%
GYRE
More free cash flow
ISSC
ISSC
$12.8M more FCF
ISSC
$7.0M
$-5.8M
GYRE
Faster 2-yr revenue CAGR
ISSC
ISSC
Annualised
ISSC
42.5%
17.0%
GYRE

Income Statement — Q4 FY2025 vs Q1 FY2026

Metric
GYRE
GYRE
ISSC
ISSC
Revenue
$37.2M
$21.8M
Net Profit
$-1.4M
$4.1M
Gross Margin
95.3%
54.5%
Operating Margin
0.3%
28.9%
Net Margin
-3.7%
18.6%
Revenue YoY
33.4%
36.6%
Net Profit YoY
-340.1%
451.4%
EPS (diluted)
$-0.01
$0.22

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
GYRE
GYRE
ISSC
ISSC
Q4 25
$37.2M
$21.8M
Q3 25
$30.6M
$22.2M
Q2 25
$26.8M
$24.1M
Q1 25
$22.1M
$21.9M
Q4 24
$27.9M
$16.0M
Q3 24
$25.5M
$15.4M
Q2 24
$25.2M
$11.8M
Q1 24
$27.2M
$10.7M
Net Profit
GYRE
GYRE
ISSC
ISSC
Q4 25
$-1.4M
$4.1M
Q3 25
$5.9M
$7.1M
Q2 25
$1.6M
$2.4M
Q1 25
$3.7M
$5.3M
Q4 24
$569.0K
$736.2K
Q3 24
$2.9M
$3.2M
Q2 24
$4.5M
$1.6M
Q1 24
$9.9M
$1.2M
Gross Margin
GYRE
GYRE
ISSC
ISSC
Q4 25
95.3%
54.5%
Q3 25
94.7%
63.2%
Q2 25
95.7%
35.5%
Q1 25
95.9%
51.4%
Q4 24
95.8%
41.4%
Q3 24
96.2%
55.4%
Q2 24
96.9%
53.4%
Q1 24
96.4%
52.0%
Operating Margin
GYRE
GYRE
ISSC
ISSC
Q4 25
0.3%
28.9%
Q3 25
22.7%
37.0%
Q2 25
8.1%
14.6%
Q1 25
10.3%
31.8%
Q4 24
2.4%
8.4%
Q3 24
16.6%
28.4%
Q2 24
12.7%
17.3%
Q1 24
29.7%
15.3%
Net Margin
GYRE
GYRE
ISSC
ISSC
Q4 25
-3.7%
18.6%
Q3 25
19.4%
32.0%
Q2 25
5.9%
10.1%
Q1 25
16.9%
24.3%
Q4 24
2.0%
4.6%
Q3 24
11.2%
20.7%
Q2 24
18.0%
13.2%
Q1 24
36.6%
11.3%
EPS (diluted)
GYRE
GYRE
ISSC
ISSC
Q4 25
$-0.01
$0.22
Q3 25
$0.03
$0.40
Q2 25
$0.00
$0.14
Q1 25
$0.00
$0.30
Q4 24
$0.00
$0.04
Q3 24
$0.01
$0.18
Q2 24
$0.01
$0.09
Q1 24
$0.03
$0.07

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
GYRE
GYRE
ISSC
ISSC
Cash + ST InvestmentsLiquidity on hand
$52.4M
$8.3M
Total DebtLower is stronger
$23.8M
Stockholders' EquityBook value
$106.0M
$68.7M
Total Assets
$166.1M
$109.9M
Debt / EquityLower = less leverage
0.35×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
GYRE
GYRE
ISSC
ISSC
Q4 25
$52.4M
$8.3M
Q3 25
$60.0M
$2.7M
Q2 25
$54.4M
$601.8K
Q1 25
$29.9M
$1.2M
Q4 24
$26.7M
$604.6K
Q3 24
$25.1M
$539.0K
Q2 24
$25.1M
$521.0K
Q1 24
$37.4M
$574.1K
Total Debt
GYRE
GYRE
ISSC
ISSC
Q4 25
$23.8M
Q3 25
$24.4M
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24
Stockholders' Equity
GYRE
GYRE
ISSC
ISSC
Q4 25
$106.0M
$68.7M
Q3 25
$101.9M
$64.6M
Q2 25
$92.0M
$56.8M
Q1 25
$68.1M
$53.5M
Q4 24
$63.3M
$47.8M
Q3 24
$63.2M
$46.6M
Q2 24
$60.4M
$43.2M
Q1 24
$56.6M
$41.4M
Total Assets
GYRE
GYRE
ISSC
ISSC
Q4 25
$166.1M
$109.9M
Q3 25
$159.4M
$103.4M
Q2 25
$152.6M
$91.8M
Q1 25
$129.8M
$89.9M
Q4 24
$125.4M
$81.3M
Q3 24
$125.2M
$82.4M
Q2 24
$120.9M
$59.8M
Q1 24
$122.0M
$57.6M
Debt / Equity
GYRE
GYRE
ISSC
ISSC
Q4 25
0.35×
Q3 25
0.38×
Q2 25
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
GYRE
GYRE
ISSC
ISSC
Operating Cash FlowLast quarter
$-5.6M
$8.2M
Free Cash FlowOCF − Capex
$-5.8M
$7.0M
FCF MarginFCF / Revenue
-15.5%
32.3%
Capex IntensityCapex / Revenue
0.4%
5.1%
Cash ConversionOCF / Net Profit
2.01×
TTM Free Cash FlowTrailing 4 quarters
$-180.0K
$12.3M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
GYRE
GYRE
ISSC
ISSC
Q4 25
$-5.6M
$8.2M
Q3 25
$4.7M
$3.0M
Q2 25
$2.1M
$7.2M
Q1 25
$-129.0K
$1.3M
Q4 24
$-2.8M
$1.8M
Q3 24
$1.7M
$445.3K
Q2 24
$-5.5M
$934.1K
Q1 24
$2.9M
$201.1K
Free Cash Flow
GYRE
GYRE
ISSC
ISSC
Q4 25
$-5.8M
$7.0M
Q3 25
$4.0M
$2.0M
Q2 25
$1.8M
$3.5M
Q1 25
$-251.0K
$-267.7K
Q4 24
$-2.8M
$1.6M
Q3 24
$1.0M
$299.5K
Q2 24
$-6.9M
$730.8K
Q1 24
$2.7M
$75.4K
FCF Margin
GYRE
GYRE
ISSC
ISSC
Q4 25
-15.5%
32.3%
Q3 25
13.1%
8.8%
Q2 25
6.8%
14.6%
Q1 25
-1.1%
-1.2%
Q4 24
-10.1%
9.9%
Q3 24
4.1%
1.9%
Q2 24
-27.5%
6.2%
Q1 24
9.8%
0.7%
Capex Intensity
GYRE
GYRE
ISSC
ISSC
Q4 25
0.4%
5.1%
Q3 25
2.2%
4.5%
Q2 25
1.0%
15.3%
Q1 25
0.6%
7.1%
Q4 24
0.2%
1.6%
Q3 24
2.7%
0.9%
Q2 24
5.8%
1.7%
Q1 24
0.9%
1.2%
Cash Conversion
GYRE
GYRE
ISSC
ISSC
Q4 25
2.01×
Q3 25
0.79×
0.42×
Q2 25
1.32×
2.95×
Q1 25
-0.03×
0.24×
Q4 24
-4.85×
2.50×
Q3 24
0.60×
0.14×
Q2 24
-1.21×
0.60×
Q1 24
0.29×
0.17×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

GYRE
GYRE

Segment breakdown not available.

ISSC
ISSC

Products$13.6M62%
Services$8.2M38%

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