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Side-by-side financial comparison of GYRE THERAPEUTICS, INC. (GYRE) and KKR Real Estate Finance Trust Inc. (KREF). Click either name above to swap in a different company.
GYRE THERAPEUTICS, INC. is the larger business by last-quarter revenue ($37.2M vs $25.8M, roughly 1.4× KKR Real Estate Finance Trust Inc.). GYRE THERAPEUTICS, INC. runs the higher net margin — -3.7% vs -101.7%, a 98.1% gap on every dollar of revenue. On growth, GYRE THERAPEUTICS, INC. posted the faster year-over-year revenue change (33.4% vs -26.6%). Over the past eight quarters, GYRE THERAPEUTICS, INC.'s revenue compounded faster (17.0% CAGR vs -18.8%).
GYRE Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing novel targeted therapies for hard-to-treat hematologic malignancies and solid tumors. It focuses on precision oncology to address unmet patient needs, with operations primarily based in North America.
KKR Real Estate Finance Trust Inc. is a specialized real estate finance firm sponsored by global investment firm KKR. It primarily originates, acquires, and manages a portfolio of senior secured commercial real estate loans, mostly backed by high-quality institutional commercial properties across the United States, delivering stable risk-adjusted returns to investors via interest income from its diversified assets.
GYRE vs KREF — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $37.2M | $25.8M |
| Net Profit | $-1.4M | $-26.2M |
| Gross Margin | 95.3% | — |
| Operating Margin | 0.3% | -105.1% |
| Net Margin | -3.7% | -101.7% |
| Revenue YoY | 33.4% | -26.6% |
| Net Profit YoY | -340.1% | -229.6% |
| EPS (diluted) | $-0.01 | $-0.49 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $37.2M | $25.8M | ||
| Q3 25 | $30.6M | $25.3M | ||
| Q2 25 | $26.8M | $30.2M | ||
| Q1 25 | $22.1M | $31.3M | ||
| Q4 24 | $27.9M | $35.1M | ||
| Q3 24 | $25.5M | $37.0M | ||
| Q2 24 | $25.2M | $40.4M | ||
| Q1 24 | $27.2M | $39.1M |
| Q4 25 | $-1.4M | $-26.2M | ||
| Q3 25 | $5.9M | $13.8M | ||
| Q2 25 | $1.6M | $-29.7M | ||
| Q1 25 | $3.7M | $-4.9M | ||
| Q4 24 | $569.0K | $20.3M | ||
| Q3 24 | $2.9M | $-7.4M | ||
| Q2 24 | $4.5M | $25.8M | ||
| Q1 24 | $9.9M | $-3.1M |
| Q4 25 | 95.3% | — | ||
| Q3 25 | 94.7% | — | ||
| Q2 25 | 95.7% | — | ||
| Q1 25 | 95.9% | — | ||
| Q4 24 | 95.8% | — | ||
| Q3 24 | 96.2% | — | ||
| Q2 24 | 96.9% | — | ||
| Q1 24 | 96.4% | — |
| Q4 25 | 0.3% | -105.1% | ||
| Q3 25 | 22.7% | 50.4% | ||
| Q2 25 | 8.1% | -101.3% | ||
| Q1 25 | 10.3% | -18.3% | ||
| Q4 24 | 2.4% | 55.8% | ||
| Q3 24 | 16.6% | -19.6% | ||
| Q2 24 | 12.7% | 63.3% | ||
| Q1 24 | 29.7% | -8.7% |
| Q4 25 | -3.7% | -101.7% | ||
| Q3 25 | 19.4% | 54.4% | ||
| Q2 25 | 5.9% | -98.5% | ||
| Q1 25 | 16.9% | -15.5% | ||
| Q4 24 | 2.0% | 57.7% | ||
| Q3 24 | 11.2% | -20.0% | ||
| Q2 24 | 18.0% | 63.9% | ||
| Q1 24 | 36.6% | -7.9% |
| Q4 25 | $-0.01 | $-0.49 | ||
| Q3 25 | $0.03 | $0.12 | ||
| Q2 25 | $0.00 | $-0.53 | ||
| Q1 25 | $0.00 | $-0.15 | ||
| Q4 24 | $0.00 | $0.22 | ||
| Q3 24 | $0.01 | $-0.19 | ||
| Q2 24 | $0.01 | $0.29 | ||
| Q1 24 | $0.03 | $-0.13 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $52.4M | $84.6M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $106.0M | $1.2B |
| Total Assets | $166.1M | $6.5B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $52.4M | $84.6M | ||
| Q3 25 | $60.0M | $204.1M | ||
| Q2 25 | $54.4M | $107.7M | ||
| Q1 25 | $29.9M | $106.4M | ||
| Q4 24 | $26.7M | $104.9M | ||
| Q3 24 | $25.1M | $108.8M | ||
| Q2 24 | $25.1M | $107.2M | ||
| Q1 24 | $37.4M | $106.5M |
| Q4 25 | $106.0M | $1.2B | ||
| Q3 25 | $101.9M | $1.2B | ||
| Q2 25 | $92.0M | $1.2B | ||
| Q1 25 | $68.1M | $1.3B | ||
| Q4 24 | $63.3M | $1.3B | ||
| Q3 24 | $63.2M | $1.4B | ||
| Q2 24 | $60.4M | $1.4B | ||
| Q1 24 | $56.6M | $1.4B |
| Q4 25 | $166.1M | $6.5B | ||
| Q3 25 | $159.4M | $6.5B | ||
| Q2 25 | $152.6M | $6.8B | ||
| Q1 25 | $129.8M | $6.6B | ||
| Q4 24 | $125.4M | $6.4B | ||
| Q3 24 | $125.2M | $6.8B | ||
| Q2 24 | $120.9M | $7.1B | ||
| Q1 24 | $122.0M | $7.3B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-5.6M | $72.3M |
| Free Cash FlowOCF − Capex | $-5.8M | — |
| FCF MarginFCF / Revenue | -15.5% | — |
| Capex IntensityCapex / Revenue | 0.4% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-180.0K | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-5.6M | $72.3M | ||
| Q3 25 | $4.7M | $18.5M | ||
| Q2 25 | $2.1M | $21.1M | ||
| Q1 25 | $-129.0K | $15.9M | ||
| Q4 24 | $-2.8M | $132.6M | ||
| Q3 24 | $1.7M | $49.1M | ||
| Q2 24 | $-5.5M | $30.6M | ||
| Q1 24 | $2.9M | $34.5M |
| Q4 25 | $-5.8M | — | ||
| Q3 25 | $4.0M | — | ||
| Q2 25 | $1.8M | — | ||
| Q1 25 | $-251.0K | — | ||
| Q4 24 | $-2.8M | — | ||
| Q3 24 | $1.0M | — | ||
| Q2 24 | $-6.9M | — | ||
| Q1 24 | $2.7M | — |
| Q4 25 | -15.5% | — | ||
| Q3 25 | 13.1% | — | ||
| Q2 25 | 6.8% | — | ||
| Q1 25 | -1.1% | — | ||
| Q4 24 | -10.1% | — | ||
| Q3 24 | 4.1% | — | ||
| Q2 24 | -27.5% | — | ||
| Q1 24 | 9.8% | — |
| Q4 25 | 0.4% | — | ||
| Q3 25 | 2.2% | — | ||
| Q2 25 | 1.0% | — | ||
| Q1 25 | 0.6% | — | ||
| Q4 24 | 0.2% | — | ||
| Q3 24 | 2.7% | — | ||
| Q2 24 | 5.8% | — | ||
| Q1 24 | 0.9% | — |
| Q4 25 | — | — | ||
| Q3 25 | 0.79× | 1.34× | ||
| Q2 25 | 1.32× | — | ||
| Q1 25 | -0.03× | — | ||
| Q4 24 | -4.85× | 6.54× | ||
| Q3 24 | 0.60× | — | ||
| Q2 24 | -1.21× | 1.19× | ||
| Q1 24 | 0.29× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
