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Side-by-side financial comparison of Hyatt Hotels Corp (H) and Vertex Pharmaceuticals (VRTX). Click either name above to swap in a different company.

Vertex Pharmaceuticals is the larger business by last-quarter revenue ($3.2B vs $1.8B, roughly 1.8× Hyatt Hotels Corp). Vertex Pharmaceuticals runs the higher net margin — 37.3% vs -1.1%, a 38.5% gap on every dollar of revenue. On growth, Hyatt Hotels Corp posted the faster year-over-year revenue change (11.7% vs 9.5%). Vertex Pharmaceuticals produced more free cash flow last quarter ($348.6M vs $236.0M). Over the past eight quarters, Vertex Pharmaceuticals's revenue compounded faster (8.9% CAGR vs 2.2%).

Hyatt Hotels Corporation, commonly known as Hyatt Hotels & Resorts, is an American multinational hospitality company headquartered in the Riverside Plaza area of Chicago that manages and franchises luxury and business hotels, resorts, and vacation properties. Hyatt Hotels & Resorts is one of the businesses managed by the Pritzker family. Hyatt has more than 1350 hotels and all-inclusive properties in 69 countries, across North America, South America, Europe, Asia, Africa and Australia.

Vertex Pharmaceuticals Incorporated is an American biopharmaceutical company based in Boston, Massachusetts. It was one of the first biotech firms to use an explicit strategy of rational drug design rather than combinatorial chemistry. It maintains headquarters in Boston, Massachusetts, and three research facilities, in San Diego, California, and Milton Park, Oxfordshire, England.

H vs VRTX — Head-to-Head

Bigger by revenue
VRTX
VRTX
1.8× larger
VRTX
$3.2B
$1.8B
H
Growing faster (revenue YoY)
H
H
+2.1% gap
H
11.7%
9.5%
VRTX
Higher net margin
VRTX
VRTX
38.5% more per $
VRTX
37.3%
-1.1%
H
More free cash flow
VRTX
VRTX
$112.6M more FCF
VRTX
$348.6M
$236.0M
H
Faster 2-yr revenue CAGR
VRTX
VRTX
Annualised
VRTX
8.9%
2.2%
H

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
H
H
VRTX
VRTX
Revenue
$1.8B
$3.2B
Net Profit
$-20.0M
$1.2B
Gross Margin
85.4%
Operating Margin
0.4%
37.8%
Net Margin
-1.1%
37.3%
Revenue YoY
11.7%
9.5%
Net Profit YoY
64.3%
30.5%
EPS (diluted)
$-0.20
$4.64

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
H
H
VRTX
VRTX
Q4 25
$1.8B
$3.2B
Q3 25
$1.8B
$3.1B
Q2 25
$1.8B
$3.0B
Q1 25
$1.7B
$2.8B
Q4 24
$1.6B
$2.9B
Q3 24
$1.6B
$2.8B
Q2 24
$1.7B
$2.6B
Q1 24
$1.7B
$2.7B
Net Profit
H
H
VRTX
VRTX
Q4 25
$-20.0M
$1.2B
Q3 25
$-49.0M
$1.1B
Q2 25
$-3.0M
$1.0B
Q1 25
$20.0M
$646.3M
Q4 24
$-56.0M
$913.0M
Q3 24
$471.0M
$1.0B
Q2 24
$359.0M
$-3.6B
Q1 24
$522.0M
$1.1B
Gross Margin
H
H
VRTX
VRTX
Q4 25
85.4%
Q3 25
86.5%
Q2 25
86.3%
Q1 25
86.9%
Q4 24
85.5%
Q3 24
85.8%
Q2 24
85.9%
Q1 24
87.3%
Operating Margin
H
H
VRTX
VRTX
Q4 25
0.4%
37.8%
Q3 25
-1.0%
38.6%
Q2 25
2.1%
38.8%
Q1 25
3.0%
22.7%
Q4 24
-3.0%
35.2%
Q3 24
37.3%
40.3%
Q2 24
27.1%
-132.9%
Q1 24
31.6%
42.4%
Net Margin
H
H
VRTX
VRTX
Q4 25
-1.1%
37.3%
Q3 25
-2.7%
35.2%
Q2 25
-0.2%
34.8%
Q1 25
1.2%
23.3%
Q4 24
-3.5%
31.4%
Q3 24
28.9%
37.7%
Q2 24
21.1%
-135.8%
Q1 24
30.5%
40.9%
EPS (diluted)
H
H
VRTX
VRTX
Q4 25
$-0.20
$4.64
Q3 25
$-0.51
$4.20
Q2 25
$-0.03
$3.99
Q1 25
$0.19
$2.49
Q4 24
$-0.37
$3.62
Q3 24
$4.63
$4.01
Q2 24
$3.46
$-13.92
Q1 24
$4.93
$4.21

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
H
H
VRTX
VRTX
Cash + ST InvestmentsLiquidity on hand
$813.0M
$6.6B
Total DebtLower is stronger
Stockholders' EquityBook value
$3.3B
$18.7B
Total Assets
$14.0B
$25.6B
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
H
H
VRTX
VRTX
Q4 25
$813.0M
$6.6B
Q3 25
$749.0M
$6.3B
Q2 25
$912.0M
$6.4B
Q1 25
$1.8B
$6.2B
Q4 24
$1.4B
$6.1B
Q3 24
$1.1B
$6.5B
Q2 24
$2.0B
$5.8B
Q1 24
$794.0M
$10.2B
Total Debt
H
H
VRTX
VRTX
Q4 25
Q3 25
$6.0B
Q2 25
$6.0B
Q1 25
$4.3B
Q4 24
$3.8B
Q3 24
$3.1B
Q2 24
$3.9B
Q1 24
$3.1B
Stockholders' Equity
H
H
VRTX
VRTX
Q4 25
$3.3B
$18.7B
Q3 25
$3.5B
$17.3B
Q2 25
$3.6B
$17.2B
Q1 25
$3.5B
$16.5B
Q4 24
$3.5B
$16.4B
Q3 24
$3.7B
$15.6B
Q2 24
$3.9B
$14.8B
Q1 24
$3.7B
$18.5B
Total Assets
H
H
VRTX
VRTX
Q4 25
$14.0B
$25.6B
Q3 25
$15.7B
$24.9B
Q2 25
$15.9B
$24.0B
Q1 25
$14.0B
$22.9B
Q4 24
$13.3B
$22.5B
Q3 24
$11.9B
$22.2B
Q2 24
$12.8B
$20.1B
Q1 24
$11.7B
$23.9B
Debt / Equity
H
H
VRTX
VRTX
Q4 25
Q3 25
1.73×
Q2 25
1.69×
Q1 25
1.25×
Q4 24
1.07×
Q3 24
0.85×
Q2 24
1.01×
Q1 24
0.84×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
H
H
VRTX
VRTX
Operating Cash FlowLast quarter
$313.0M
$498.0M
Free Cash FlowOCF − Capex
$236.0M
$348.6M
FCF MarginFCF / Revenue
13.2%
10.9%
Capex IntensityCapex / Revenue
4.3%
4.7%
Cash ConversionOCF / Net Profit
0.42×
TTM Free Cash FlowTrailing 4 quarters
$159.0M
$3.2B

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
H
H
VRTX
VRTX
Q4 25
$313.0M
$498.0M
Q3 25
$-20.0M
$1.2B
Q2 25
$-67.0M
$1.1B
Q1 25
$153.0M
$818.9M
Q4 24
$235.0M
$584.6M
Q3 24
$-21.0M
$1.4B
Q2 24
$177.0M
$-3.8B
Q1 24
$242.0M
$1.3B
Free Cash Flow
H
H
VRTX
VRTX
Q4 25
$236.0M
$348.6M
Q3 25
$-89.0M
$1.1B
Q2 25
$-111.0M
$927.4M
Q1 25
$123.0M
$778.2M
Q4 24
$184.0M
$492.0M
Q3 24
$-64.0M
$1.3B
Q2 24
$135.0M
$-3.8B
Q1 24
$208.0M
$1.2B
FCF Margin
H
H
VRTX
VRTX
Q4 25
13.2%
10.9%
Q3 25
-5.0%
37.0%
Q2 25
-6.1%
31.3%
Q1 25
7.2%
28.1%
Q4 24
11.5%
16.9%
Q3 24
-3.9%
47.0%
Q2 24
7.9%
-144.5%
Q1 24
12.1%
46.0%
Capex Intensity
H
H
VRTX
VRTX
Q4 25
4.3%
4.7%
Q3 25
3.9%
3.3%
Q2 25
2.4%
4.9%
Q1 25
1.7%
1.5%
Q4 24
3.2%
3.2%
Q3 24
2.6%
2.4%
Q2 24
2.5%
2.6%
Q1 24
2.0%
2.5%
Cash Conversion
H
H
VRTX
VRTX
Q4 25
0.42×
Q3 25
1.15×
Q2 25
1.04×
Q1 25
7.65×
1.27×
Q4 24
0.64×
Q3 24
-0.04×
1.31×
Q2 24
0.49×
Q1 24
0.46×
1.19×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

H
H

Other$627.0M35%
Rooms Revenue$326.0M18%
Net Fees$290.0M16%
Distribution Segment$177.0M10%
Franchise And Other Fees$114.0M6%
Base Management Fees$112.0M6%
Incentive Management Fees$81.0M5%
Other Owned And Leased Hotel Revenue$41.0M2%
Contra Revenue$17.0M1%
Other Revenues$4.0M0%

VRTX
VRTX

TRIKAFTAKAFTRIO$2.6B81%
ALYFTREK$380.1M12%
Manufactured Product Other$237.4M7%

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