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Side-by-side financial comparison of HYPERION DEFI, INC. (HYPD) and Iterum Therapeutics plc (ITRM). Click either name above to swap in a different company.
HYPERION DEFI, INC. is the larger business by last-quarter revenue ($496.2K vs $390.0K, roughly 1.3× Iterum Therapeutics plc).
Iterum Therapeutics plc is a clinical-stage biopharmaceutical company specializing in developing innovative anti-infective therapies to treat infections caused by multi-drug resistant bacteria. Its lead product candidate targets indications including community-acquired bacterial pneumonia and complicated urinary tract infections, addressing unmet medical needs across global healthcare markets.
HYPD vs ITRM — Head-to-Head
Income Statement — Q4 FY2025 vs Q3 FY2025
| Metric | | |
|---|---|---|
| Revenue | $496.2K | $390.0K |
| Net Profit | — | $-9.0M |
| Gross Margin | 38.9% | — |
| Operating Margin | -8013.5% | -1982.3% |
| Net Margin | — | -2302.3% |
| Revenue YoY | 1666.4% | — |
| Net Profit YoY | — | -47.3% |
| EPS (diluted) | $-5.36 | $-0.20 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $496.2K | — | ||
| Q3 25 | $302.5K | $390.0K | ||
| Q2 25 | $0 | — | ||
| Q1 25 | $14.7K | — | ||
| Q4 24 | $28.1K | — | ||
| Q3 24 | $1.6K | — | ||
| Q2 24 | $22.6K | — | ||
| Q1 24 | $5.0K | — |
| Q4 25 | — | — | ||
| Q3 25 | $6.6M | $-9.0M | ||
| Q2 25 | $-8.7M | — | ||
| Q1 25 | $-3.5M | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $-7.9M | — | ||
| Q2 24 | $-11.1M | — | ||
| Q1 24 | $-10.9M | — |
| Q4 25 | 38.9% | — | ||
| Q3 25 | 100.0% | — | ||
| Q2 25 | — | — | ||
| Q1 25 | 99.7% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | -8013.5% | — | ||
| Q3 25 | — | -1982.3% | ||
| Q2 25 | — | — | ||
| Q1 25 | -20588.9% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | -451195.5% | — | ||
| Q2 24 | -51661.2% | — | ||
| Q1 24 | -205624.4% | — |
| Q4 25 | — | — | ||
| Q3 25 | 2190.2% | -2302.3% | ||
| Q2 25 | — | — | ||
| Q1 25 | -23665.3% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | -485406.3% | — | ||
| Q2 24 | -48856.1% | — | ||
| Q1 24 | -218748.3% | — |
| Q4 25 | $-5.36 | — | ||
| Q3 25 | $0.05 | $-0.20 | ||
| Q2 25 | $-2.50 | — | ||
| Q1 25 | $-1.59 | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $-9.07 | — | ||
| Q2 24 | $-16.65 | — | ||
| Q1 24 | $-18.75 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $6.4M | $11.0M |
| Total DebtLower is stronger | — | $20.0M |
| Stockholders' EquityBook value | $41.1M | $-7.4M |
| Total Assets | $51.8M | $32.5M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $6.4M | — | ||
| Q3 25 | $8.2M | $11.0M | ||
| Q2 25 | $7.5M | — | ||
| Q1 25 | $3.9M | — | ||
| Q4 24 | $2.1M | — | ||
| Q3 24 | $7.2M | — | ||
| Q2 24 | $2.3M | — | ||
| Q1 24 | $8.0M | — |
| Q4 25 | — | — | ||
| Q3 25 | — | $20.0M | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $41.1M | — | ||
| Q3 25 | $70.8M | $-7.4M | ||
| Q2 25 | $37.4M | — | ||
| Q1 25 | $-9.7M | — | ||
| Q4 24 | $-13.1M | — | ||
| Q3 24 | $3.7M | — | ||
| Q2 24 | $-2.4M | — | ||
| Q1 24 | $1.8M | — |
| Q4 25 | $51.8M | — | ||
| Q3 25 | $82.8M | $32.5M | ||
| Q2 25 | $55.7M | — | ||
| Q1 25 | $6.0M | — | ||
| Q4 24 | $3.7M | — | ||
| Q3 24 | $22.8M | — | ||
| Q2 24 | $19.0M | — | ||
| Q1 24 | $26.2M | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-4.1M | $-7.4M |
| Free Cash FlowOCF − Capex | — | $-7.5M |
| FCF MarginFCF / Revenue | — | -1912.6% |
| Capex IntensityCapex / Revenue | — | 3.1% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-4.1M | — | ||
| Q3 25 | $-2.8M | $-7.4M | ||
| Q2 25 | $-3.4M | — | ||
| Q1 25 | $-4.4M | — | ||
| Q4 24 | $-30.1M | — | ||
| Q3 24 | $-5.9M | — | ||
| Q2 24 | $-8.2M | — | ||
| Q1 24 | $-9.9M | — |
| Q4 25 | — | — | ||
| Q3 25 | — | $-7.5M | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $-30.3M | — | ||
| Q3 24 | $-5.9M | — | ||
| Q2 24 | $-8.2M | — | ||
| Q1 24 | $-10.0M | — |
| Q4 25 | — | — | ||
| Q3 25 | — | -1912.6% | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | -107793.6% | — | ||
| Q3 24 | -365875.5% | — | ||
| Q2 24 | -36332.5% | — | ||
| Q1 24 | -200397.6% | — |
| Q4 25 | — | — | ||
| Q3 25 | — | 3.1% | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 574.8% | — | ||
| Q3 24 | 99.9% | — | ||
| Q2 24 | 202.2% | — | ||
| Q1 24 | 2285.3% | — |
| Q4 25 | — | — | ||
| Q3 25 | -0.43× | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
