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Side-by-side financial comparison of ICON PLC (ICLR) and iSpecimen Inc. (ISPC). Click either name above to swap in a different company.

ICON PLC is the larger business by last-quarter revenue ($2.0B vs $51.8K, roughly 39466.2× iSpecimen Inc.). ICON PLC runs the higher net margin — 0.1% vs -9662.2%, a 9662.3% gap on every dollar of revenue. On growth, ICON PLC posted the faster year-over-year revenue change (0.6% vs -96.5%). Over the past eight quarters, ICON PLC's revenue compounded faster (0.6% CAGR vs -85.0%).

ICON plc is an Irish headquartered multinational healthcare intelligence and clinical research organisation. As of February 2025 had approximately 41,900 employees in 55 countries.

Specimen Products is a Chicago-based manufacturer of custom guitars, tube amplifiers, and audio horn speakers led by luthier Ian Schneller. Specimen Products also offers courses in guitar and tube amplifier design, construction, and repair through their Chicago School of Guitar Making. The Specimen workshop offers repair services to the general public, making use of their collection of parts from rare and vintage manufacturers.

ICLR vs ISPC — Head-to-Head

Bigger by revenue
ICLR
ICLR
39466.2× larger
ICLR
$2.0B
$51.8K
ISPC
Growing faster (revenue YoY)
ICLR
ICLR
+97.1% gap
ICLR
0.6%
-96.5%
ISPC
Higher net margin
ICLR
ICLR
9662.3% more per $
ICLR
0.1%
-9662.2%
ISPC
Faster 2-yr revenue CAGR
ICLR
ICLR
Annualised
ICLR
0.6%
-85.0%
ISPC

Income Statement — Q3 2025 vs Q4 2025

Metric
ICLR
ICLR
ISPC
ISPC
Revenue
$2.0B
$51.8K
Net Profit
$2.4M
$-5.0M
Gross Margin
-964.4%
Operating Margin
4.2%
-5192.9%
Net Margin
0.1%
-9662.2%
Revenue YoY
0.6%
-96.5%
Net Profit YoY
-98.8%
17.3%
EPS (diluted)
$0.03
$-0.67

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ICLR
ICLR
ISPC
ISPC
Q4 25
$51.8K
Q3 25
$2.0B
$106.6K
Q2 25
$2.0B
$713.1K
Q1 25
$2.0B
$1.1M
Q4 24
$1.5M
Q3 24
$2.0B
$2.7M
Q2 24
$2.1B
$2.9M
Q1 24
$2.1B
$2.3M
Net Profit
ICLR
ICLR
ISPC
ISPC
Q4 25
$-5.0M
Q3 25
$2.4M
$-2.8M
Q2 25
$183.0M
$-1.0M
Q1 25
$154.2M
$-1.7M
Q4 24
$-6.0M
Q3 24
$197.1M
$-1.4M
Q2 24
$146.9M
$-2.1M
Q1 24
$187.4M
$-2.9M
Gross Margin
ICLR
ICLR
ISPC
ISPC
Q4 25
-964.4%
Q3 25
-47.0%
Q2 25
44.4%
Q1 25
42.4%
Q4 24
13.5%
Q3 24
43.4%
Q2 24
51.9%
Q1 24
58.4%
Operating Margin
ICLR
ICLR
ISPC
ISPC
Q4 25
-5192.9%
Q3 25
4.2%
-2655.2%
Q2 25
10.4%
-255.4%
Q1 25
11.0%
-154.9%
Q4 24
-395.8%
Q3 24
14.1%
-64.1%
Q2 24
10.8%
-76.2%
Q1 24
13.7%
-131.0%
Net Margin
ICLR
ICLR
ISPC
ISPC
Q4 25
-9662.2%
Q3 25
0.1%
-2608.7%
Q2 25
9.1%
-146.9%
Q1 25
7.7%
-156.8%
Q4 24
-409.8%
Q3 24
9.7%
-54.1%
Q2 24
6.9%
-73.6%
Q1 24
9.0%
-126.7%
EPS (diluted)
ICLR
ICLR
ISPC
ISPC
Q4 25
$-0.67
Q3 25
$0.03
$-0.48
Q2 25
$2.30
$-0.42
Q1 25
$1.90
$-0.71
Q4 24
$-5.40
Q3 24
$2.36
$-2.10
Q2 24
$1.76
$-3.72
Q1 24
$2.25
$-6.36

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ICLR
ICLR
ISPC
ISPC
Cash + ST InvestmentsLiquidity on hand
$468.9M
$6.9M
Total DebtLower is stronger
Stockholders' EquityBook value
$9.3B
$3.1M
Total Assets
$16.5B
$9.5M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ICLR
ICLR
ISPC
ISPC
Q4 25
$6.9M
Q3 25
$468.9M
Q2 25
$390.4M
Q1 25
$526.7M
Q4 24
$1.9M
Q3 24
$695.5M
$1.8M
Q2 24
$506.6M
$2.2M
Q1 24
$396.1M
$2.1M
Stockholders' Equity
ICLR
ICLR
ISPC
ISPC
Q4 25
$3.1M
Q3 25
$9.3B
$3.1M
Q2 25
$9.6B
$622.0K
Q1 25
$9.5B
$1.7M
Q4 24
$3.3M
Q3 24
$9.8B
$4.7M
Q2 24
$9.6B
$6.1M
Q1 24
$9.4B
$6.8M
Total Assets
ICLR
ICLR
ISPC
ISPC
Q4 25
$9.5M
Q3 25
$16.5B
$9.0M
Q2 25
$16.6B
$6.0M
Q1 25
$16.7B
$6.8M
Q4 24
$9.4M
Q3 24
$17.2B
$11.3M
Q2 24
$17.0B
$11.9M
Q1 24
$17.0B
$12.5M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ICLR
ICLR
ISPC
ISPC
Operating Cash FlowLast quarter
$387.6M
$-916.9K
Free Cash FlowOCF − Capex
$333.9M
FCF MarginFCF / Revenue
16.3%
Capex IntensityCapex / Revenue
2.6%
Cash ConversionOCF / Net Profit
164.59×
TTM Free Cash FlowTrailing 4 quarters
$1.0B

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ICLR
ICLR
ISPC
ISPC
Q4 25
$-916.9K
Q3 25
$387.6M
$-2.0M
Q2 25
$146.2M
$-192.2K
Q1 25
$268.2M
$-1.1M
Q4 24
$-3.6M
Q3 24
$402.7M
$-1.1M
Q2 24
$218.6M
$-1.5M
Q1 24
$327.1M
$-2.1M
Free Cash Flow
ICLR
ICLR
ISPC
ISPC
Q4 25
Q3 25
$333.9M
Q2 25
$113.9M
Q1 25
$239.3M
Q4 24
$-3.6M
Q3 24
$359.3M
$-1.1M
Q2 24
$182.3M
Q1 24
$299.9M
$-2.1M
FCF Margin
ICLR
ICLR
ISPC
ISPC
Q4 25
Q3 25
16.3%
Q2 25
5.6%
Q1 25
12.0%
Q4 24
-242.7%
Q3 24
17.7%
-41.1%
Q2 24
8.6%
Q1 24
14.3%
-90.9%
Capex Intensity
ICLR
ICLR
ISPC
ISPC
Q4 25
Q3 25
2.6%
0.0%
Q2 25
1.6%
Q1 25
1.4%
Q4 24
0.5%
Q3 24
2.1%
0.5%
Q2 24
1.7%
0.0%
Q1 24
1.3%
0.4%
Cash Conversion
ICLR
ICLR
ISPC
ISPC
Q4 25
Q3 25
164.59×
Q2 25
0.80×
Q1 25
1.74×
Q4 24
Q3 24
2.04×
Q2 24
1.49×
Q1 24
1.74×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ICLR
ICLR

Other Customers$681.3M33%
Clients1125$549.4M27%
Clients15$503.3M25%
Clients610$308.8M15%

ISPC
ISPC

Segment breakdown not available.

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