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Side-by-side financial comparison of ILLUMINA, INC. (ILMN) and SPIRE INC (SR). Click either name above to swap in a different company.

ILLUMINA, INC. is the larger business by last-quarter revenue ($1.1B vs $762.2M, roughly 1.4× SPIRE INC). SPIRE INC runs the higher net margin — 12.5% vs 12.3%, a 0.2% gap on every dollar of revenue. On growth, SPIRE INC posted the faster year-over-year revenue change (13.9% vs 4.8%). ILLUMINA, INC. produced more free cash flow last quarter ($251.0M vs $-121.8M). Over the past eight quarters, ILLUMINA, INC.'s revenue compounded faster (-1.3% CAGR vs -17.8%).

Illumina, Inc. is an American biotechnology company, headquartered in San Diego, California. Incorporated on April 1, 1998, Illumina develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression, and proteomics markets, and serves more than 155 countries.

Spire Inc. is a regional public utility holding company based in St. Louis, Missouri, providing natural gas service through its regulated core utility operations while engaging in non-regulated activities that provide business opportunities. Its primary subsidiary Laclede Gas Company is the largest natural gas distribution utility in Missouri, serving approximately 631,000 residential, commercial and industrial customers in the City of St. Louis and ten counties in eastern Missouri. Its corpo...

ILMN vs SR — Head-to-Head

Bigger by revenue
ILMN
ILMN
1.4× larger
ILMN
$1.1B
$762.2M
SR
Growing faster (revenue YoY)
SR
SR
+9.1% gap
SR
13.9%
4.8%
ILMN
Higher net margin
SR
SR
0.2% more per $
SR
12.5%
12.3%
ILMN
More free cash flow
ILMN
ILMN
$372.8M more FCF
ILMN
$251.0M
$-121.8M
SR
Faster 2-yr revenue CAGR
ILMN
ILMN
Annualised
ILMN
-1.3%
-17.8%
SR

Income Statement — Q1 FY2027 vs Q1 FY2026

Metric
ILMN
ILMN
SR
SR
Revenue
$1.1B
$762.2M
Net Profit
$134.0M
$95.0M
Gross Margin
66.1%
55.1%
Operating Margin
19.2%
22.8%
Net Margin
12.3%
12.5%
Revenue YoY
4.8%
13.9%
Net Profit YoY
16.9%
EPS (diluted)
$0.87
$1.54

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ILMN
ILMN
SR
SR
Q1 26
$1.1B
Q4 25
$1.2B
$762.2M
Q3 25
$334.1M
Q2 25
$421.9M
Q1 25
$1.1B
Q4 24
$1.1B
$669.1M
Q3 24
$1.1B
$293.8M
Q2 24
$1.1B
$414.1M
Net Profit
ILMN
ILMN
SR
SR
Q1 26
$134.0M
Q4 25
$334.0M
$95.0M
Q3 25
$-39.8M
Q2 25
$20.9M
Q1 25
$209.3M
Q4 24
$186.0M
$81.3M
Q3 24
$705.0M
$-25.9M
Q2 24
$-2.0B
$-12.6M
Gross Margin
ILMN
ILMN
SR
SR
Q1 26
66.1%
Q4 25
65.5%
55.1%
Q3 25
Q2 25
Q1 25
Q4 24
65.9%
55.6%
Q3 24
69.0%
Q2 24
64.8%
Operating Margin
ILMN
ILMN
SR
SR
Q1 26
19.2%
Q4 25
17.4%
22.8%
Q3 25
-0.1%
Q2 25
16.4%
Q1 25
29.1%
Q4 24
15.8%
22.2%
Q3 24
68.6%
6.7%
Q2 24
-147.2%
7.4%
Net Margin
ILMN
ILMN
SR
SR
Q1 26
12.3%
Q4 25
28.8%
12.5%
Q3 25
-11.9%
Q2 25
5.0%
Q1 25
19.9%
Q4 24
16.8%
12.2%
Q3 24
65.3%
-8.8%
Q2 24
-178.8%
-3.0%
EPS (diluted)
ILMN
ILMN
SR
SR
Q1 26
$0.87
Q4 25
$2.16
$1.54
Q3 25
$-0.77
Q2 25
$0.29
Q1 25
$3.51
Q4 24
$1.16
$1.34
Q3 24
$4.42
$-0.63
Q2 24
$-12.48
$-0.28

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ILMN
ILMN
SR
SR
Cash + ST InvestmentsLiquidity on hand
$1.2B
$4.1M
Total DebtLower is stronger
Stockholders' EquityBook value
$2.7B
$3.4B
Total Assets
$6.6B
$11.9B
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ILMN
ILMN
SR
SR
Q1 26
$1.2B
Q4 25
$1.6B
$4.1M
Q3 25
$5.7M
Q2 25
$13.1M
Q1 25
$15.2M
Q4 24
$93.0M
$11.5M
Q3 24
$70.0M
$4.5M
Q2 24
$74.0M
$7.4M
Stockholders' Equity
ILMN
ILMN
SR
SR
Q1 26
$2.7B
Q4 25
$2.7B
$3.4B
Q3 25
$3.4B
Q2 25
$3.5B
Q1 25
$3.5B
Q4 24
$2.4B
$3.3B
Q3 24
$2.1B
$3.2B
Q2 24
$1.4B
$3.3B
Total Assets
ILMN
ILMN
SR
SR
Q1 26
$6.6B
Q4 25
$6.6B
$11.9B
Q3 25
$11.6B
Q2 25
$11.4B
Q1 25
$11.3B
Q4 24
$6.3B
$11.3B
Q3 24
$6.0B
$10.9B
Q2 24
$6.1B
$10.7B

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ILMN
ILMN
SR
SR
Operating Cash FlowLast quarter
$289.0M
$81.0M
Free Cash FlowOCF − Capex
$251.0M
$-121.8M
FCF MarginFCF / Revenue
23.0%
-16.0%
Capex IntensityCapex / Revenue
26.6%
Cash ConversionOCF / Net Profit
2.16×
0.85×
TTM Free Cash FlowTrailing 4 quarters
$1.1B
$-286.7M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ILMN
ILMN
SR
SR
Q1 26
$289.0M
Q4 25
$321.0M
$81.0M
Q3 25
$-4.9M
Q2 25
$129.1M
Q1 25
$372.7M
Q4 24
$364.0M
$81.1M
Q3 24
$316.0M
$82.9M
Q2 24
$80.0M
$270.1M
Free Cash Flow
ILMN
ILMN
SR
SR
Q1 26
$251.0M
Q4 25
$267.0M
$-121.8M
Q3 25
$-227.6M
Q2 25
$-91.4M
Q1 25
$154.1M
Q4 24
$335.0M
$-179.5M
Q3 24
$284.0M
$-146.9M
Q2 24
$49.0M
$47.9M
FCF Margin
ILMN
ILMN
SR
SR
Q1 26
23.0%
Q4 25
23.0%
-16.0%
Q3 25
-68.1%
Q2 25
-21.7%
Q1 25
14.7%
Q4 24
30.3%
-26.8%
Q3 24
26.3%
-50.0%
Q2 24
4.4%
11.6%
Capex Intensity
ILMN
ILMN
SR
SR
Q1 26
Q4 25
26.6%
Q3 25
66.7%
Q2 25
52.3%
Q1 25
20.8%
Q4 24
2.6%
38.9%
Q3 24
3.0%
78.2%
Q2 24
2.8%
53.7%
Cash Conversion
ILMN
ILMN
SR
SR
Q1 26
2.16×
Q4 25
0.96×
0.85×
Q3 25
Q2 25
6.18×
Q1 25
1.78×
Q4 24
1.96×
1.00×
Q3 24
0.45×
Q2 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ILMN
ILMN

Product revenue$917.0M84%
Service and other revenue$174.0M16%

SR
SR

Residential$474.9M62%
Commercial And Industrial$148.4M19%
Gas Marketing$41.1M5%
Midstream$39.0M5%
Transportation$37.1M5%
Offsystem And Other Inventive$19.7M3%
Other Customer Revenue$4.6M1%

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