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Side-by-side financial comparison of IONIS PHARMACEUTICALS INC (IONS) and SHOE CARNIVAL INC (SCVL). Click either name above to swap in a different company.

SHOE CARNIVAL INC is the larger business by last-quarter revenue ($297.2M vs $203.3M, roughly 1.5× IONIS PHARMACEUTICALS INC). SHOE CARNIVAL INC runs the higher net margin — 4.9% vs -112.8%, a 117.7% gap on every dollar of revenue. On growth, SHOE CARNIVAL INC posted the faster year-over-year revenue change (-3.2% vs -10.3%). SHOE CARNIVAL INC produced more free cash flow last quarter ($19.7M vs $-159.0M). Over the past eight quarters, IONIS PHARMACEUTICALS INC's revenue compounded faster (30.4% CAGR vs 3.0%).

Ionis Pharmaceuticals, Inc. is a biotechnology company that specializes in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics. The company was founded in 1989 is based in Carlsbad, California. The company was previously known as Isis Pharmaceuticals until December 2015.

Shoe Carnival Inc. is an American retailer of family footwear. The company operates 429 stores throughout the midwest, south, and southeast regions, and Puerto Rico. It was founded by David Russell in 1978 and is headquartered in Fort Mill, South Carolina as of 2025.

IONS vs SCVL — Head-to-Head

Bigger by revenue
SCVL
SCVL
1.5× larger
SCVL
$297.2M
$203.3M
IONS
Growing faster (revenue YoY)
SCVL
SCVL
+7.1% gap
SCVL
-3.2%
-10.3%
IONS
Higher net margin
SCVL
SCVL
117.7% more per $
SCVL
4.9%
-112.8%
IONS
More free cash flow
SCVL
SCVL
$178.7M more FCF
SCVL
$19.7M
$-159.0M
IONS
Faster 2-yr revenue CAGR
IONS
IONS
Annualised
IONS
30.4%
3.0%
SCVL

Income Statement — Q4 FY2025 vs Q3 FY2026

Metric
IONS
IONS
SCVL
SCVL
Revenue
$203.3M
$297.2M
Net Profit
$-229.4M
$14.6M
Gross Margin
96.1%
37.6%
Operating Margin
-105.5%
6.3%
Net Margin
-112.8%
4.9%
Revenue YoY
-10.3%
-3.2%
Net Profit YoY
-119.8%
-23.9%
EPS (diluted)
$-1.35
$0.53

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
IONS
IONS
SCVL
SCVL
Q4 25
$203.3M
$297.2M
Q3 25
$156.7M
$306.4M
Q2 25
$452.0M
$277.7M
Q1 25
$131.6M
$262.9M
Q4 24
$226.6M
$306.9M
Q3 24
$133.8M
$332.7M
Q2 24
$225.3M
$300.4M
Q1 24
$119.5M
$280.2M
Net Profit
IONS
IONS
SCVL
SCVL
Q4 25
$-229.4M
$14.6M
Q3 25
$-128.6M
$19.2M
Q2 25
$123.6M
$9.3M
Q1 25
$-146.9M
$14.7M
Q4 24
$-104.3M
$19.2M
Q3 24
$-140.5M
$22.6M
Q2 24
$-66.3M
$17.3M
Q1 24
$-142.8M
$15.5M
Gross Margin
IONS
IONS
SCVL
SCVL
Q4 25
96.1%
37.6%
Q3 25
98.5%
38.8%
Q2 25
99.1%
34.5%
Q1 25
98.9%
34.9%
Q4 24
98.3%
36.0%
Q3 24
99.2%
36.1%
Q2 24
98.2%
35.6%
Q1 24
98.2%
35.6%
Operating Margin
IONS
IONS
SCVL
SCVL
Q4 25
-105.5%
6.3%
Q3 25
-102.2%
8.2%
Q2 25
30.9%
4.3%
Q1 25
-111.6%
5.3%
Q4 24
-48.9%
8.0%
Q3 24
-111.1%
9.0%
Q2 24
-29.3%
7.5%
Q1 24
-125.1%
7.1%
Net Margin
IONS
IONS
SCVL
SCVL
Q4 25
-112.8%
4.9%
Q3 25
-82.1%
6.3%
Q2 25
27.3%
3.4%
Q1 25
-111.6%
5.6%
Q4 24
-46.1%
6.3%
Q3 24
-105.0%
6.8%
Q2 24
-29.4%
5.8%
Q1 24
-119.5%
5.5%
EPS (diluted)
IONS
IONS
SCVL
SCVL
Q4 25
$-1.35
$0.53
Q3 25
$-0.80
$0.70
Q2 25
$0.70
$0.34
Q1 25
$-0.93
$0.53
Q4 24
$-0.66
$0.70
Q3 24
$-0.95
$0.82
Q2 24
$-0.45
$0.63
Q1 24
$-0.98
$0.57

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
IONS
IONS
SCVL
SCVL
Cash + ST InvestmentsLiquidity on hand
$2.7B
$107.7M
Total DebtLower is stronger
$1.8B
Stockholders' EquityBook value
$489.1M
$683.2M
Total Assets
$3.5B
$1.2B
Debt / EquityLower = less leverage
3.71×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
IONS
IONS
SCVL
SCVL
Q4 25
$2.7B
$107.7M
Q3 25
$2.2B
$91.9M
Q2 25
$2.3B
$93.0M
Q1 25
$2.1B
$123.1M
Q4 24
$2.3B
$91.1M
Q3 24
$2.5B
$84.5M
Q2 24
$2.1B
$69.5M
Q1 24
$2.2B
$111.2M
Total Debt
IONS
IONS
SCVL
SCVL
Q4 25
$1.8B
Q3 25
Q2 25
Q1 25
Q4 24
$1.3B
Q3 24
Q2 24
Q1 24
Stockholders' Equity
IONS
IONS
SCVL
SCVL
Q4 25
$489.1M
$683.2M
Q3 25
$618.0M
$670.7M
Q2 25
$631.7M
$653.6M
Q1 25
$475.7M
$649.0M
Q4 24
$588.4M
$635.7M
Q3 24
$662.5M
$618.5M
Q2 24
$263.7M
$597.8M
Q1 24
$296.5M
$583.4M
Total Assets
IONS
IONS
SCVL
SCVL
Q4 25
$3.5B
$1.2B
Q3 25
$3.0B
$1.2B
Q2 25
$3.0B
$1.1B
Q1 25
$2.8B
$1.1B
Q4 24
$3.0B
$1.1B
Q3 24
$3.1B
$1.1B
Q2 24
$2.7B
$1.1B
Q1 24
$2.8B
$1.0B
Debt / Equity
IONS
IONS
SCVL
SCVL
Q4 25
3.71×
Q3 25
Q2 25
Q1 25
Q4 24
2.13×
Q3 24
Q2 24
Q1 24

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
IONS
IONS
SCVL
SCVL
Operating Cash FlowLast quarter
$-137.7M
$33.6M
Free Cash FlowOCF − Capex
$-159.0M
$19.7M
FCF MarginFCF / Revenue
-78.2%
6.6%
Capex IntensityCapex / Revenue
10.5%
4.7%
Cash ConversionOCF / Net Profit
2.30×
TTM Free Cash FlowTrailing 4 quarters
$-320.0M
$35.1M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
IONS
IONS
SCVL
SCVL
Q4 25
$-137.7M
$33.6M
Q3 25
$-131.4M
$13.3M
Q2 25
$151.3M
$-9.6M
Q1 25
$-150.8M
$44.5M
Q4 24
$-116.1M
$17.3M
Q3 24
$-115.0M
$23.7M
Q2 24
$-119.9M
$17.1M
Q1 24
$-149.9M
$53.4M
Free Cash Flow
IONS
IONS
SCVL
SCVL
Q4 25
$-159.0M
$19.7M
Q3 25
$-136.7M
$2.2M
Q2 25
$139.0M
$-23.0M
Q1 25
$-163.4M
$36.2M
Q4 24
$-141.6M
$8.3M
Q3 24
$-124.0M
$18.2M
Q2 24
$-126.1M
$6.9M
Q1 24
$-154.4M
$40.7M
FCF Margin
IONS
IONS
SCVL
SCVL
Q4 25
-78.2%
6.6%
Q3 25
-87.2%
0.7%
Q2 25
30.8%
-8.3%
Q1 25
-124.1%
13.8%
Q4 24
-62.5%
2.7%
Q3 24
-92.7%
5.5%
Q2 24
-56.0%
2.3%
Q1 24
-129.2%
14.5%
Capex Intensity
IONS
IONS
SCVL
SCVL
Q4 25
10.5%
4.7%
Q3 25
3.4%
3.6%
Q2 25
2.7%
4.8%
Q1 25
9.6%
3.2%
Q4 24
11.3%
3.0%
Q3 24
6.8%
1.7%
Q2 24
2.8%
3.4%
Q1 24
3.8%
4.5%
Cash Conversion
IONS
IONS
SCVL
SCVL
Q4 25
2.30×
Q3 25
0.69×
Q2 25
1.22×
-1.03×
Q1 25
3.04×
Q4 24
0.90×
Q3 24
1.05×
Q2 24
0.99×
Q1 24
3.44×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

IONS
IONS

Products$58.0M29%
Spinraza Royalties$54.0M27%
Collaborative Agreement Revenue$52.4M26%
Wainus Royalties$16.0M8%
Wainua Joint Development Revenue$9.6M5%
Other Commercial$7.6M4%
Other Royalties$5.7M3%

SCVL
SCVL

Segment breakdown not available.

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