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Side-by-side financial comparison of IONIS PHARMACEUTICALS INC (IONS) and S&T BANCORP INC (STBA). Click either name above to swap in a different company.
IONIS PHARMACEUTICALS INC is the larger business by last-quarter revenue ($203.3M vs $102.1M, roughly 2.0× S&T BANCORP INC). S&T BANCORP INC runs the higher net margin — 34.4% vs -112.8%, a 147.2% gap on every dollar of revenue. Over the past eight quarters, IONIS PHARMACEUTICALS INC's revenue compounded faster (30.4% CAGR vs 2.6%).
Ionis Pharmaceuticals, Inc. is a biotechnology company that specializes in discovering and developing antisense therapy, as well as RNA interference and CRISPR therapeutics. The company was founded in 1989 is based in Carlsbad, California. The company was previously known as Isis Pharmaceuticals until December 2015.
U.S. Bancorp is an American multinational banking institution headquartered in Minneapolis, Minnesota and incorporated in Delaware. It is the 5th-largest bank in the United States as of 2025. As the largest bank in the Midwestern United States, it is considered systemically important by the Financial Stability Board. It is the parent company of its primary operating entity, U.S. Bank National Association, which does business as U.S. Bank. The company provides banking, investment, mortgage, tr...
IONS vs STBA — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $203.3M | $102.1M |
| Net Profit | $-229.4M | $35.1M |
| Gross Margin | 96.1% | — |
| Operating Margin | -105.5% | — |
| Net Margin | -112.8% | 34.4% |
| Revenue YoY | -10.3% | — |
| Net Profit YoY | -119.8% | 5.0% |
| EPS (diluted) | $-1.35 | $0.94 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $102.1M | ||
| Q4 25 | $203.3M | $105.3M | ||
| Q3 25 | $156.7M | $103.0M | ||
| Q2 25 | $452.0M | $100.1M | ||
| Q1 25 | $131.6M | $93.8M | ||
| Q4 24 | $226.6M | $94.3M | ||
| Q3 24 | $133.8M | $96.4M | ||
| Q2 24 | $225.3M | $96.9M |
| Q1 26 | — | $35.1M | ||
| Q4 25 | $-229.4M | $34.0M | ||
| Q3 25 | $-128.6M | $35.0M | ||
| Q2 25 | $123.6M | $31.9M | ||
| Q1 25 | $-146.9M | $33.4M | ||
| Q4 24 | $-104.3M | $33.1M | ||
| Q3 24 | $-140.5M | $32.6M | ||
| Q2 24 | $-66.3M | $34.4M |
| Q1 26 | — | — | ||
| Q4 25 | 96.1% | — | ||
| Q3 25 | 98.5% | — | ||
| Q2 25 | 99.1% | — | ||
| Q1 25 | 98.9% | — | ||
| Q4 24 | 98.3% | — | ||
| Q3 24 | 99.2% | — | ||
| Q2 24 | 98.2% | — |
| Q1 26 | — | — | ||
| Q4 25 | -105.5% | 40.3% | ||
| Q3 25 | -102.2% | 42.6% | ||
| Q2 25 | 30.9% | 40.0% | ||
| Q1 25 | -111.6% | 44.5% | ||
| Q4 24 | -48.9% | 43.8% | ||
| Q3 24 | -111.1% | 43.0% | ||
| Q2 24 | -29.3% | 44.2% |
| Q1 26 | — | 34.4% | ||
| Q4 25 | -112.8% | 32.3% | ||
| Q3 25 | -82.1% | 33.9% | ||
| Q2 25 | 27.3% | 31.9% | ||
| Q1 25 | -111.6% | 35.6% | ||
| Q4 24 | -46.1% | 35.1% | ||
| Q3 24 | -105.0% | 33.8% | ||
| Q2 24 | -29.4% | 35.5% |
| Q1 26 | — | $0.94 | ||
| Q4 25 | $-1.35 | $0.88 | ||
| Q3 25 | $-0.80 | $0.91 | ||
| Q2 25 | $0.70 | $0.83 | ||
| Q1 25 | $-0.93 | $0.87 | ||
| Q4 24 | $-0.66 | $0.86 | ||
| Q3 24 | $-0.95 | $0.85 | ||
| Q2 24 | $-0.45 | $0.89 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $2.7B | — |
| Total DebtLower is stronger | $1.8B | $100.8M |
| Stockholders' EquityBook value | $489.1M | $1.4B |
| Total Assets | $3.5B | $9.9B |
| Debt / EquityLower = less leverage | 3.71× | 0.07× |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $2.7B | $163.4M | ||
| Q3 25 | $2.2B | $196.2M | ||
| Q2 25 | $2.3B | $203.1M | ||
| Q1 25 | $2.1B | $211.8M | ||
| Q4 24 | $2.3B | $244.8M | ||
| Q3 24 | $2.5B | $228.1M | ||
| Q2 24 | $2.1B | $246.3M |
| Q1 26 | — | $100.8M | ||
| Q4 25 | $1.8B | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $1.3B | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — |
| Q1 26 | — | $1.4B | ||
| Q4 25 | $489.1M | $1.5B | ||
| Q3 25 | $618.0M | $1.5B | ||
| Q2 25 | $631.7M | $1.4B | ||
| Q1 25 | $475.7M | $1.4B | ||
| Q4 24 | $588.4M | $1.4B | ||
| Q3 24 | $662.5M | $1.4B | ||
| Q2 24 | $263.7M | $1.3B |
| Q1 26 | — | $9.9B | ||
| Q4 25 | $3.5B | $9.9B | ||
| Q3 25 | $3.0B | $9.8B | ||
| Q2 25 | $3.0B | $9.8B | ||
| Q1 25 | $2.8B | $9.7B | ||
| Q4 24 | $3.0B | $9.7B | ||
| Q3 24 | $3.1B | $9.6B | ||
| Q2 24 | $2.7B | $9.6B |
| Q1 26 | — | 0.07× | ||
| Q4 25 | 3.71× | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 2.13× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-137.7M | — |
| Free Cash FlowOCF − Capex | $-159.0M | — |
| FCF MarginFCF / Revenue | -78.2% | — |
| Capex IntensityCapex / Revenue | 10.5% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-320.0M | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $-137.7M | $133.6M | ||
| Q3 25 | $-131.4M | $40.5M | ||
| Q2 25 | $151.3M | $28.3M | ||
| Q1 25 | $-150.8M | $28.7M | ||
| Q4 24 | $-116.1M | $173.4M | ||
| Q3 24 | $-115.0M | $27.6M | ||
| Q2 24 | $-119.9M | $44.7M |
| Q1 26 | — | — | ||
| Q4 25 | $-159.0M | $128.8M | ||
| Q3 25 | $-136.7M | $39.9M | ||
| Q2 25 | $139.0M | $27.1M | ||
| Q1 25 | $-163.4M | $27.0M | ||
| Q4 24 | $-141.6M | $170.4M | ||
| Q3 24 | $-124.0M | $26.9M | ||
| Q2 24 | $-126.1M | $43.9M |
| Q1 26 | — | — | ||
| Q4 25 | -78.2% | 122.4% | ||
| Q3 25 | -87.2% | 38.7% | ||
| Q2 25 | 30.8% | 27.1% | ||
| Q1 25 | -124.1% | 28.8% | ||
| Q4 24 | -62.5% | 180.7% | ||
| Q3 24 | -92.7% | 28.0% | ||
| Q2 24 | -56.0% | 45.3% |
| Q1 26 | — | — | ||
| Q4 25 | 10.5% | 4.5% | ||
| Q3 25 | 3.4% | 0.6% | ||
| Q2 25 | 2.7% | 1.2% | ||
| Q1 25 | 9.6% | 1.8% | ||
| Q4 24 | 11.3% | 3.1% | ||
| Q3 24 | 6.8% | 0.7% | ||
| Q2 24 | 2.8% | 0.9% |
| Q1 26 | — | — | ||
| Q4 25 | — | 3.93× | ||
| Q3 25 | — | 1.16× | ||
| Q2 25 | 1.22× | 0.89× | ||
| Q1 25 | — | 0.86× | ||
| Q4 24 | — | 5.24× | ||
| Q3 24 | — | 0.85× | ||
| Q2 24 | — | 1.30× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
IONS
| Products | $58.0M | 29% |
| Spinraza Royalties | $54.0M | 27% |
| Collaborative Agreement Revenue | $52.4M | 26% |
| Wainus Royalties | $16.0M | 8% |
| Wainua Joint Development Revenue | $9.6M | 5% |
| Other Commercial | $7.6M | 4% |
| Other Royalties | $5.7M | 3% |
STBA
| Net Interest Income | $88.4M | 87% |
| Noninterest Income | $13.6M | 13% |
