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Side-by-side financial comparison of IOVANCE BIOTHERAPEUTICS, INC. (IOVA) and Yatsen Holding Ltd (YSG). Click either name above to swap in a different company.
Yatsen Holding Ltd is the larger business by last-quarter revenue ($164.2M vs $86.8M, roughly 1.9× IOVANCE BIOTHERAPEUTICS, INC.). Over the past eight quarters, IOVANCE BIOTHERAPEUTICS, INC.'s revenue compounded faster (1001.6% CAGR vs 24.5%).
Iovance Biotherapeutics, Inc. is a biopharmaceutical startup based in San Carlos, California. The company works to develop tumor-infiltrating lymphocyte (TIL) therapies against cancer.
Yatsen Holding Ltd is a leading China-based beauty and personal care group. It develops and sells cosmetics, skincare products and fragrances under brands including Perfect Diary, Little Ondine and Abby's Choice, with core markets in mainland China, Southeast Asia, targeting Gen Z and young adult consumers.
IOVA vs YSG — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $86.8M | $164.2M |
| Net Profit | — | $-776.5K |
| Gross Margin | 67.4% | 77.8% |
| Operating Margin | -84.7% | -34.0% |
| Net Margin | — | -0.5% |
| Revenue YoY | 17.7% | — |
| Net Profit YoY | — | — |
| EPS (diluted) | — | — |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $86.8M | $164.2M | ||
| Q3 25 | $67.5M | $95.1M | ||
| Q2 25 | $60.0M | $110.9M | ||
| Q1 25 | $49.3M | $106.6M | ||
| Q4 24 | $73.7M | $147.0M | ||
| Q3 24 | $58.6M | $102.3M | ||
| Q2 24 | $31.1M | $118.1M | ||
| Q1 24 | $715.0K | $106.0M |
| Q4 25 | — | $-776.5K | ||
| Q3 25 | $-91.3M | $-17.0M | ||
| Q2 25 | $-111.7M | $-11.9M | ||
| Q1 25 | $-116.2M | $-17.2M | ||
| Q4 24 | — | $-67.7M | ||
| Q3 24 | $-83.5M | $-28.2M | ||
| Q2 24 | $-97.1M | $-14.9M | ||
| Q1 24 | $-113.0M | $7.0M |
| Q4 25 | 67.4% | 77.8% | ||
| Q3 25 | 43.0% | 75.9% | ||
| Q2 25 | 5.5% | 76.7% | ||
| Q1 25 | -0.8% | 77.7% | ||
| Q4 24 | 68.7% | 73.7% | ||
| Q3 24 | 46.2% | 71.4% | ||
| Q2 24 | -0.8% | 74.7% | ||
| Q1 24 | — | 74.3% |
| Q4 25 | -84.7% | -34.0% | ||
| Q3 25 | -140.7% | -20.9% | ||
| Q2 25 | -189.8% | -17.0% | ||
| Q1 25 | -245.8% | -20.4% | ||
| Q4 24 | -117.5% | -50.3% | ||
| Q3 24 | -152.1% | -32.2% | ||
| Q2 24 | -327.6% | -15.7% | ||
| Q1 24 | -16464.6% | -0.9% |
| Q4 25 | — | -0.5% | ||
| Q3 25 | -135.3% | -17.9% | ||
| Q2 25 | -186.2% | -10.8% | ||
| Q1 25 | -235.5% | -16.1% | ||
| Q4 24 | — | -46.1% | ||
| Q3 24 | -142.7% | -27.6% | ||
| Q2 24 | -312.2% | -12.6% | ||
| Q1 24 | -15800.8% | 6.6% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | $-0.33 | — | ||
| Q1 25 | $-0.36 | — | ||
| Q4 24 | $-0.24 | — | ||
| Q3 24 | $-0.28 | — | ||
| Q2 24 | $-0.34 | — | ||
| Q1 24 | $-0.42 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $297.0M | $109.4M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $698.6M | $428.9M |
| Total Assets | $913.2M | $550.1M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $297.0M | $109.4M | ||
| Q3 25 | $300.8M | $97.0M | ||
| Q2 25 | $301.2M | $133.1M | ||
| Q1 25 | $359.7M | $92.3M | ||
| Q4 24 | $323.8M | $112.0M | ||
| Q3 24 | $397.5M | $71.7M | ||
| Q2 24 | $412.5M | $109.6M | ||
| Q1 24 | $356.2M | $179.9M |
| Q4 25 | $698.6M | $428.9M | ||
| Q3 25 | $702.3M | $423.1M | ||
| Q2 25 | $698.5M | $431.5M | ||
| Q1 25 | $767.9M | $422.2M | ||
| Q4 24 | $710.4M | $418.1M | ||
| Q3 24 | $773.5M | $516.0M | ||
| Q2 24 | $768.5M | $519.4M | ||
| Q1 24 | $680.0M | $551.6M |
| Q4 25 | $913.2M | $550.1M | ||
| Q3 25 | $904.9M | $564.8M | ||
| Q2 25 | $907.4M | $564.4M | ||
| Q1 25 | $966.7M | $534.3M | ||
| Q4 24 | $910.4M | $544.0M | ||
| Q3 24 | $991.1M | $635.6M | ||
| Q2 24 | $964.3M | $635.8M | ||
| Q1 24 | $869.8M | $662.1M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-52.6M | — |
| Free Cash FlowOCF − Capex | $-61.9M | — |
| FCF MarginFCF / Revenue | -71.3% | — |
| Capex IntensityCapex / Revenue | 10.7% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-336.2M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-52.6M | — | ||
| Q3 25 | $-78.7M | — | ||
| Q2 25 | $-67.4M | — | ||
| Q1 25 | $-103.7M | — | ||
| Q4 24 | $-73.3M | — | ||
| Q3 24 | $-59.0M | — | ||
| Q2 24 | $-98.4M | — | ||
| Q1 24 | $-122.3M | — |
| Q4 25 | $-61.9M | — | ||
| Q3 25 | $-89.5M | — | ||
| Q2 25 | $-74.9M | — | ||
| Q1 25 | $-109.9M | — | ||
| Q4 24 | $-77.5M | — | ||
| Q3 24 | $-61.3M | — | ||
| Q2 24 | $-98.9M | — | ||
| Q1 24 | $-126.5M | — |
| Q4 25 | -71.3% | — | ||
| Q3 25 | -132.7% | — | ||
| Q2 25 | -124.9% | — | ||
| Q1 25 | -222.8% | — | ||
| Q4 24 | -105.1% | — | ||
| Q3 24 | -104.6% | — | ||
| Q2 24 | -317.9% | — | ||
| Q1 24 | -17685.3% | — |
| Q4 25 | 10.7% | — | ||
| Q3 25 | 16.1% | — | ||
| Q2 25 | 12.4% | — | ||
| Q1 25 | 12.6% | — | ||
| Q4 24 | 5.7% | — | ||
| Q3 24 | 3.9% | — | ||
| Q2 24 | 1.4% | — | ||
| Q1 24 | 583.4% | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
IOVA
| Amtagvi | $64.9M | 75% |
| Proleukin | $21.9M | 25% |
YSG
Segment breakdown not available.
