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Side-by-side financial comparison of IRONWOOD PHARMACEUTICALS INC (IRWD) and STEM, INC. (STEM). Click either name above to swap in a different company.
IRONWOOD PHARMACEUTICALS INC is the larger business by last-quarter revenue ($47.7M vs $47.1M, roughly 1.0× STEM, INC.). IRONWOOD PHARMACEUTICALS INC runs the higher net margin — -4.8% vs -33.9%, a 29.1% gap on every dollar of revenue. On growth, STEM, INC. posted the faster year-over-year revenue change (-15.6% vs -47.3%). Over the past eight quarters, STEM, INC.'s revenue compounded faster (36.1% CAGR vs -20.2%).
Ironwood Pharmaceuticals, Inc. is a publicly traded pharmaceutical company. It was originally called Microbia, Inc.
StemCells, Inc. is a public biopharmaceutical company headquartered in Newark, California, that is developing purified human neural stem cells (HuCNS-SCs) in the hopes of treating central nervous system disorders and paralysis. StemCells' HuCNS-SCs have the ability to differentiate into the three main types of cells found in the central nervous system: neurons, astrocytes and oligodendrocytes.
IRWD vs STEM — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $47.7M | $47.1M |
| Net Profit | $-2.3M | $-16.0M |
| Gross Margin | — | 48.9% |
| Operating Margin | 14.3% | -17.7% |
| Net Margin | -4.8% | -33.9% |
| Revenue YoY | -47.3% | -15.6% |
| Net Profit YoY | -200.9% | 68.8% |
| EPS (diluted) | $0.01 | $-4.40 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $47.7M | $47.1M | ||
| Q3 25 | $122.1M | $38.2M | ||
| Q2 25 | $85.2M | $38.4M | ||
| Q1 25 | $41.1M | $32.5M | ||
| Q4 24 | $90.5M | $55.8M | ||
| Q3 24 | $91.6M | $29.3M | ||
| Q2 24 | $94.4M | $34.0M | ||
| Q1 24 | $74.9M | $25.5M |
| Q4 25 | $-2.3M | $-16.0M | ||
| Q3 25 | $40.1M | $-23.8M | ||
| Q2 25 | $23.6M | $202.5M | ||
| Q1 25 | $-37.4M | $-25.0M | ||
| Q4 24 | $2.3M | $-51.1M | ||
| Q3 24 | $3.6M | $-148.3M | ||
| Q2 24 | $-860.0K | $-582.3M | ||
| Q1 24 | $-4.2M | $-72.3M |
| Q4 25 | — | 48.9% | ||
| Q3 25 | — | 35.5% | ||
| Q2 25 | — | 33.4% | ||
| Q1 25 | — | 32.4% | ||
| Q4 24 | — | -4.4% | ||
| Q3 24 | — | 21.2% | ||
| Q2 24 | — | 27.6% | ||
| Q1 24 | — | -95.0% |
| Q4 25 | 14.3% | -17.7% | ||
| Q3 25 | 61.8% | -33.6% | ||
| Q2 25 | 53.2% | -34.8% | ||
| Q1 25 | -70.7% | -65.0% | ||
| Q4 24 | 34.8% | -84.4% | ||
| Q3 24 | 28.0% | -493.2% | ||
| Q2 24 | 26.5% | -1705.5% | ||
| Q1 24 | 14.7% | -267.0% |
| Q4 25 | -4.8% | -33.9% | ||
| Q3 25 | 32.8% | -62.2% | ||
| Q2 25 | 27.7% | 527.8% | ||
| Q1 25 | -90.9% | -76.9% | ||
| Q4 24 | 2.5% | -91.6% | ||
| Q3 24 | 4.0% | -506.3% | ||
| Q2 24 | -0.9% | -1712.6% | ||
| Q1 24 | -5.6% | -283.9% |
| Q4 25 | $0.01 | $-4.40 | ||
| Q3 25 | $0.23 | $-2.84 | ||
| Q2 25 | $0.14 | $-1.79 | ||
| Q1 25 | $-0.23 | $-0.15 | ||
| Q4 24 | $0.03 | $-15.29 | ||
| Q3 24 | $0.02 | $-18.24 | ||
| Q2 24 | $-0.01 | $-71.81 | ||
| Q1 24 | $-0.03 | $-0.46 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $215.5M | $48.9M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $-261.8M | $-249.4M |
| Total Assets | $396.9M | $308.9M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $215.5M | $48.9M | ||
| Q3 25 | $140.4M | $43.1M | ||
| Q2 25 | $92.9M | $40.8M | ||
| Q1 25 | $108.5M | $58.6M | ||
| Q4 24 | $88.6M | $56.3M | ||
| Q3 24 | $88.2M | $75.4M | ||
| Q2 24 | $105.5M | $89.6M | ||
| Q1 24 | $121.5M | $112.8M |
| Q4 25 | — | — | ||
| Q3 25 | $199.5M | — | ||
| Q2 25 | $199.3M | — | ||
| Q1 25 | $199.2M | — | ||
| Q4 24 | $199.0M | — | ||
| Q3 24 | $198.8M | — | ||
| Q2 24 | $198.6M | — | ||
| Q1 24 | $398.3M | — |
| Q4 25 | $-261.8M | $-249.4M | ||
| Q3 25 | $-264.2M | $-235.7M | ||
| Q2 25 | $-308.2M | $-214.1M | ||
| Q1 25 | $-334.1M | $-417.5M | ||
| Q4 24 | $-301.3M | $-398.4M | ||
| Q3 24 | $-311.3M | $-344.1M | ||
| Q2 24 | $-321.7M | $-203.2M | ||
| Q1 24 | $-330.5M | $371.6M |
| Q4 25 | $396.9M | $308.9M | ||
| Q3 25 | $396.1M | $362.6M | ||
| Q2 25 | $342.9M | $379.2M | ||
| Q1 25 | $327.2M | $405.1M | ||
| Q4 24 | $350.9M | $437.4M | ||
| Q3 24 | $389.5M | $537.8M | ||
| Q2 24 | $395.6M | $691.5M | ||
| Q1 24 | $438.8M | $1.3B |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $74.6M | $8.2M |
| Free Cash FlowOCF − Capex | $74.6M | — |
| FCF MarginFCF / Revenue | 156.3% | — |
| Capex IntensityCapex / Revenue | 0.0% | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $127.0M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $74.6M | $8.2M | ||
| Q3 25 | $47.6M | $11.4M | ||
| Q2 25 | $-15.1M | $-21.3M | ||
| Q1 25 | $20.0M | $8.5M | ||
| Q4 24 | $15.2M | $-14.7M | ||
| Q3 24 | $9.9M | $-9.4M | ||
| Q2 24 | $33.5M | $-11.9M | ||
| Q1 24 | $45.0M | $-621.0K |
| Q4 25 | $74.6M | — | ||
| Q3 25 | $47.6M | — | ||
| Q2 25 | $-15.1M | — | ||
| Q1 25 | $19.9M | — | ||
| Q4 24 | — | — | ||
| Q3 24 | $9.9M | — | ||
| Q2 24 | $33.4M | — | ||
| Q1 24 | $44.9M | — |
| Q4 25 | 156.3% | — | ||
| Q3 25 | 39.0% | — | ||
| Q2 25 | -17.7% | — | ||
| Q1 25 | 48.4% | — | ||
| Q4 24 | — | — | ||
| Q3 24 | 10.8% | — | ||
| Q2 24 | 35.4% | — | ||
| Q1 24 | 60.0% | — |
| Q4 25 | 0.0% | — | ||
| Q3 25 | 0.0% | — | ||
| Q2 25 | 0.0% | — | ||
| Q1 25 | 0.1% | — | ||
| Q4 24 | 0.0% | — | ||
| Q3 24 | 0.0% | — | ||
| Q2 24 | 0.1% | — | ||
| Q1 24 | 0.1% | — |
| Q4 25 | — | — | ||
| Q3 25 | 1.19× | — | ||
| Q2 25 | -0.64× | -0.11× | ||
| Q1 25 | — | — | ||
| Q4 24 | 6.74× | — | ||
| Q3 24 | 2.71× | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
