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Side-by-side financial comparison of iSpecimen Inc. (ISPC) and TherapeuticsMD, Inc. (TXMD). Click either name above to swap in a different company.

TherapeuticsMD, Inc. is the larger business by last-quarter revenue ($893.0K vs $713.1K, roughly 1.3× iSpecimen Inc.). On growth, TherapeuticsMD, Inc. posted the faster year-over-year revenue change (33.9% vs -75.1%). Over the past eight quarters, TherapeuticsMD, Inc.'s revenue compounded faster (68.9% CAGR vs -49.3%).

Specimen Products is a Chicago-based manufacturer of custom guitars, tube amplifiers, and audio horn speakers led by luthier Ian Schneller. Specimen Products also offers courses in guitar and tube amplifier design, construction, and repair through their Chicago School of Guitar Making. The Specimen workshop offers repair services to the general public, making use of their collection of parts from rare and vintage manufacturers.

Nektar Therapeutics is an American biopharmaceutical company. The company was founded in 1990 and is based in San Francisco, California. The company develops new drug candidates by applying its proprietary PEGylation and advanced polymer conjugate technologies to modify chemical structure of substances, which improves drug characteristics like retention and solubility. It is a technology supplier to a number of pharmaceutical companies including Affymax, Amgen, Merck, Pfizer and UCB Pharma, e...

ISPC vs TXMD — Head-to-Head

Bigger by revenue
TXMD
TXMD
1.3× larger
TXMD
$893.0K
$713.1K
ISPC
Growing faster (revenue YoY)
TXMD
TXMD
+109.0% gap
TXMD
33.9%
-75.1%
ISPC
Faster 2-yr revenue CAGR
TXMD
TXMD
Annualised
TXMD
68.9%
-49.3%
ISPC

Income Statement — Q2 FY2025 vs Q4 FY2025

Metric
ISPC
ISPC
TXMD
TXMD
Revenue
$713.1K
$893.0K
Net Profit
$-1.0M
Gross Margin
44.4%
Operating Margin
-255.4%
Net Margin
-146.9%
Revenue YoY
-75.1%
33.9%
Net Profit YoY
50.3%
-345.6%
EPS (diluted)
$-0.42

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ISPC
ISPC
TXMD
TXMD
Q4 25
$893.0K
Q3 25
$784.0K
Q2 25
$713.1K
$952.0K
Q1 25
$1.1M
$393.0K
Q4 24
$1.5M
$667.0K
Q3 24
$2.7M
$547.0K
Q2 24
$2.9M
$234.0K
Q1 24
$2.3M
$313.0K
Net Profit
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
$152.0K
Q2 25
$-1.0M
$551.0K
Q1 25
$-1.7M
$-653.0K
Q4 24
$-6.0M
Q3 24
$-1.4M
$-609.0K
Q2 24
$-2.1M
$-1.1M
Q1 24
$-2.9M
$-734.0K
Gross Margin
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
Q2 25
44.4%
Q1 25
42.4%
Q4 24
13.5%
Q3 24
43.4%
Q2 24
51.9%
Q1 24
58.4%
Operating Margin
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
-109.9%
Q2 25
-255.4%
-73.0%
Q1 25
-154.9%
-221.6%
Q4 24
-395.8%
Q3 24
-64.1%
-207.3%
Q2 24
-76.2%
-1191.9%
Q1 24
-131.0%
-364.9%
Net Margin
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
19.4%
Q2 25
-146.9%
57.9%
Q1 25
-156.8%
-166.2%
Q4 24
-409.8%
Q3 24
-54.1%
-111.3%
Q2 24
-73.6%
-465.8%
Q1 24
-126.7%
-234.5%
EPS (diluted)
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
$0.01
Q2 25
$-0.42
$0.05
Q1 25
$-0.71
$-0.06
Q4 24
$-5.40
Q3 24
$-2.10
$-0.05
Q2 24
$-3.72
$-0.09
Q1 24
$-6.36
$-0.06

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ISPC
ISPC
TXMD
TXMD
Cash + ST InvestmentsLiquidity on hand
Total DebtLower is stronger
Stockholders' EquityBook value
$622.0K
$26.9M
Total Assets
$6.0M
$37.7M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
Q2 25
Q1 25
$5.7M
Q4 24
$1.9M
$5.1M
Q3 24
$1.8M
Q2 24
$2.2M
Q1 24
$2.1M
Stockholders' Equity
ISPC
ISPC
TXMD
TXMD
Q4 25
$26.9M
Q3 25
$27.4M
Q2 25
$622.0K
$27.3M
Q1 25
$1.7M
$26.7M
Q4 24
$3.3M
$27.4M
Q3 24
$4.7M
$27.1M
Q2 24
$6.1M
$27.7M
Q1 24
$6.8M
$28.7M
Total Assets
ISPC
ISPC
TXMD
TXMD
Q4 25
$37.7M
Q3 25
$38.7M
Q2 25
$6.0M
$38.5M
Q1 25
$6.8M
$38.2M
Q4 24
$9.4M
$38.8M
Q3 24
$11.3M
Q2 24
$11.9M
$40.1M
Q1 24
$12.5M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ISPC
ISPC
TXMD
TXMD
Operating Cash FlowLast quarter
$-192.2K
$2.5M
Free Cash FlowOCF − Capex
FCF MarginFCF / Revenue
Capex IntensityCapex / Revenue
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ISPC
ISPC
TXMD
TXMD
Q4 25
$2.5M
Q3 25
$999.0K
Q2 25
$-192.2K
$381.0K
Q1 25
$-1.1M
$699.0K
Q4 24
$-3.6M
$1.2M
Q3 24
$-1.1M
$-71.0K
Q2 24
$-1.5M
$1.5M
Q1 24
$-2.1M
$-229.0K
Free Cash Flow
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
$-3.6M
Q3 24
$-1.1M
Q2 24
Q1 24
$-2.1M
FCF Margin
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
-242.7%
Q3 24
-41.1%
Q2 24
Q1 24
-90.9%
Capex Intensity
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
Q2 25
Q1 25
Q4 24
0.5%
Q3 24
0.5%
Q2 24
0.0%
Q1 24
0.4%
Cash Conversion
ISPC
ISPC
TXMD
TXMD
Q4 25
Q3 25
6.57×
Q2 25
0.69×
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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