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Side-by-side financial comparison of OPKO HEALTH, INC. (OPK) and PROASSURANCE CORP (PRA). Click either name above to swap in a different company.

PROASSURANCE CORP is the larger business by last-quarter revenue ($269.6M vs $148.5M, roughly 1.8× OPKO HEALTH, INC.). PROASSURANCE CORP runs the higher net margin — 12.4% vs -21.1%, a 33.4% gap on every dollar of revenue. On growth, PROASSURANCE CORP posted the faster year-over-year revenue change (-7.1% vs -19.2%). Over the past eight quarters, PROASSURANCE CORP's revenue compounded faster (-2.7% CAGR vs -7.5%).

OPKO Health, Inc. is a medical test and medication company focused on diagnostics and pharmaceuticals. The company is a publicly traded company on NASDAQ and TASE under the symbol "OPK".

ProAssurance Corporation, headquartered in Birmingham, Alabama, is a property and casualty company that sells professional liability insurance to doctors. The company was founded in 1976 as Mutual Assurance and was later renamed to Medical Assurance in 1997. The name "ProAssurance" was created in 2001 when Medical Assurance merged with Professionals Group. The company is currently the fourth largest medical professional liability insurance writer and has over $6 billion in assets.

OPK vs PRA — Head-to-Head

Bigger by revenue
PRA
PRA
1.8× larger
PRA
$269.6M
$148.5M
OPK
Growing faster (revenue YoY)
PRA
PRA
+12.1% gap
PRA
-7.1%
-19.2%
OPK
Higher net margin
PRA
PRA
33.4% more per $
PRA
12.4%
-21.1%
OPK
Faster 2-yr revenue CAGR
PRA
PRA
Annualised
PRA
-2.7%
-7.5%
OPK

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
OPK
OPK
PRA
PRA
Revenue
$148.5M
$269.6M
Net Profit
$-31.3M
$33.4M
Gross Margin
43.1%
Operating Margin
-25.8%
17.3%
Net Margin
-21.1%
12.4%
Revenue YoY
-19.2%
-7.1%
Net Profit YoY
-322.8%
106.4%
EPS (diluted)
$-0.04
$0.65

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
OPK
OPK
PRA
PRA
Q4 25
$148.5M
$269.6M
Q3 25
$151.7M
$279.6M
Q2 25
$156.8M
$276.8M
Q1 25
$150.0M
$272.1M
Q4 24
$183.6M
$290.1M
Q3 24
$173.6M
$285.3M
Q2 24
$182.2M
$290.4M
Q1 24
$173.7M
$284.7M
Net Profit
OPK
OPK
PRA
PRA
Q4 25
$-31.3M
$33.4M
Q3 25
$21.6M
$1.4M
Q2 25
$-148.4M
$21.9M
Q1 25
$-67.6M
$-5.8M
Q4 24
$14.0M
$16.2M
Q3 24
$24.9M
$16.4M
Q2 24
$-10.3M
$15.5M
Q1 24
$-81.8M
$4.6M
Gross Margin
OPK
OPK
PRA
PRA
Q4 25
43.1%
Q3 25
32.9%
Q2 25
31.5%
Q1 25
28.4%
Q4 24
46.1%
Q3 24
23.1%
Q2 24
28.4%
Q1 24
24.2%
Operating Margin
OPK
OPK
PRA
PRA
Q4 25
-25.8%
17.3%
Q3 25
31.7%
1.6%
Q2 25
-38.3%
9.9%
Q1 25
-44.8%
-2.3%
Q4 24
-18.0%
6.5%
Q3 24
8.2%
7.4%
Q2 24
-33.9%
6.2%
Q1 24
-41.2%
1.9%
Net Margin
OPK
OPK
PRA
PRA
Q4 25
-21.1%
12.4%
Q3 25
14.3%
0.5%
Q2 25
-94.7%
7.9%
Q1 25
-45.1%
-2.1%
Q4 24
7.6%
5.6%
Q3 24
14.3%
5.8%
Q2 24
-5.7%
5.3%
Q1 24
-47.1%
1.6%
EPS (diluted)
OPK
OPK
PRA
PRA
Q4 25
$-0.04
$0.65
Q3 25
$0.03
$0.03
Q2 25
$-0.19
$0.42
Q1 25
$-0.10
$-0.11
Q4 24
$0.02
$0.32
Q3 24
$0.03
$0.32
Q2 24
$-0.01
$0.30
Q1 24
$-0.12
$0.09

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
OPK
OPK
PRA
PRA
Cash + ST InvestmentsLiquidity on hand
$364.4M
$36.5M
Total DebtLower is stronger
$344.0M
$420.4M
Stockholders' EquityBook value
$1.3B
$1.3B
Total Assets
$1.9B
$5.4B
Debt / EquityLower = less leverage
0.27×
0.31×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
OPK
OPK
PRA
PRA
Q4 25
$364.4M
$36.5M
Q3 25
$412.0M
$54.5M
Q2 25
$267.3M
$41.6M
Q1 25
$428.8M
$43.5M
Q4 24
$426.6M
$54.9M
Q3 24
$400.1M
$45.3M
Q2 24
$40.6M
$36.9M
Q1 24
$75.6M
$65.4M
Total Debt
OPK
OPK
PRA
PRA
Q4 25
$344.0M
$420.4M
Q3 25
$344.2M
$421.5M
Q2 25
$343.3M
$422.6M
Q1 25
$439.2M
$423.7M
Q4 24
$437.2M
$424.9M
Q3 24
$441.0M
$425.9M
Q2 24
$201.9M
$426.9M
Q1 24
$350.1M
$427.8M
Stockholders' Equity
OPK
OPK
PRA
PRA
Q4 25
$1.3B
$1.3B
Q3 25
$1.3B
$1.3B
Q2 25
$1.3B
$1.3B
Q1 25
$1.3B
$1.2B
Q4 24
$1.4B
$1.2B
Q3 24
$1.4B
$1.2B
Q2 24
$1.4B
$1.1B
Q1 24
$1.3B
$1.1B
Total Assets
OPK
OPK
PRA
PRA
Q4 25
$1.9B
$5.4B
Q3 25
$2.0B
$5.6B
Q2 25
$2.0B
$5.5B
Q1 25
$2.1B
$5.5B
Q4 24
$2.2B
$5.6B
Q3 24
$2.3B
$5.7B
Q2 24
$2.0B
$5.6B
Q1 24
$2.0B
$5.7B
Debt / Equity
OPK
OPK
PRA
PRA
Q4 25
0.27×
0.31×
Q3 25
0.26×
0.32×
Q2 25
0.26×
0.33×
Q1 25
0.33×
0.34×
Q4 24
0.32×
0.35×
Q3 24
0.31×
0.35×
Q2 24
0.14×
0.38×
Q1 24
0.28×
0.38×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
OPK
OPK
PRA
PRA
Operating Cash FlowLast quarter
$-25.9M
$-25.6M
Free Cash FlowOCF − Capex
$-28.6M
FCF MarginFCF / Revenue
-19.3%
Capex IntensityCapex / Revenue
1.8%
Cash ConversionOCF / Net Profit
-0.77×
TTM Free Cash FlowTrailing 4 quarters
$-190.8M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
OPK
OPK
PRA
PRA
Q4 25
$-25.9M
$-25.6M
Q3 25
$-34.6M
$27.2M
Q2 25
$-83.4M
$-28.1M
Q1 25
$-34.6M
$-11.6M
Q4 24
$-44.4M
$-10.7M
Q3 24
$-77.1M
$14.0M
Q2 24
$-26.4M
$-12.8M
Q1 24
$-35.6M
$-11.6M
Free Cash Flow
OPK
OPK
PRA
PRA
Q4 25
$-28.6M
Q3 25
$-37.8M
Q2 25
$-86.7M
Q1 25
$-37.7M
Q4 24
$-49.8M
Q3 24
$-85.0M
Q2 24
$-33.7M
Q1 24
$-40.0M
FCF Margin
OPK
OPK
PRA
PRA
Q4 25
-19.3%
Q3 25
-24.9%
Q2 25
-55.3%
Q1 25
-25.2%
Q4 24
-27.1%
Q3 24
-49.0%
Q2 24
-18.5%
Q1 24
-23.0%
Capex Intensity
OPK
OPK
PRA
PRA
Q4 25
1.8%
Q3 25
2.1%
Q2 25
2.1%
Q1 25
2.1%
Q4 24
2.9%
Q3 24
4.6%
Q2 24
4.0%
Q1 24
2.6%
Cash Conversion
OPK
OPK
PRA
PRA
Q4 25
-0.77×
Q3 25
-1.60×
18.81×
Q2 25
-1.28×
Q1 25
Q4 24
-3.17×
-0.66×
Q3 24
-3.10×
0.85×
Q2 24
-0.83×
Q1 24
-2.52×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

OPK
OPK

Services$71.1M48%
Transfer Of Intellectual Property And Other$33.7M23%
IE$22.1M15%
Rayaldee$8.8M6%
Barda Agreement$6.8M5%
MX$6.3M4%

PRA
PRA

Workers Compensation Insurance Segment$164.4M61%
Other$59.6M22%
Segregated Portfolio Cell Reinsurance$45.7M17%

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