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Side-by-side financial comparison of OPKO HEALTH, INC. (OPK) and Zai Lab Ltd (ZLAB). Click either name above to swap in a different company.
OPKO HEALTH, INC. is the larger business by last-quarter revenue ($148.5M vs $127.1M, roughly 1.2× Zai Lab Ltd). On growth, Zai Lab Ltd posted the faster year-over-year revenue change (17.1% vs -19.2%). Zai Lab Ltd produced more free cash flow last quarter ($-26.7M vs $-28.6M). Over the past eight quarters, Zai Lab Ltd's revenue compounded faster (20.8% CAGR vs -7.5%).
OPKO Health, Inc. is a medical test and medication company focused on diagnostics and pharmaceuticals. The company is a publicly traded company on NASDAQ and TASE under the symbol "OPK".
Zai Lab Ltd is a global biopharmaceutical company focused on developing, manufacturing and commercializing innovative therapies for oncology, autoimmune disorders, infectious diseases and other unmet medical needs. It operates primarily in the Greater China region and partners with leading global biotech firms to expand access to life-saving treatments for underserved patient populations.
OPK vs ZLAB — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $148.5M | $127.1M |
| Net Profit | $-31.3M | — |
| Gross Margin | 43.1% | 51.0% |
| Operating Margin | -25.8% | -54.6% |
| Net Margin | -21.1% | — |
| Revenue YoY | -19.2% | 17.1% |
| Net Profit YoY | -322.8% | — |
| EPS (diluted) | $-0.04 | $-0.05 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $148.5M | $127.1M | ||
| Q3 25 | $151.7M | $115.4M | ||
| Q2 25 | $156.8M | $109.1M | ||
| Q1 25 | $150.0M | $105.7M | ||
| Q4 24 | $183.6M | $108.5M | ||
| Q3 24 | $173.6M | $101.8M | ||
| Q2 24 | $182.2M | $100.1M | ||
| Q1 24 | $173.7M | $87.1M |
| Q4 25 | $-31.3M | — | ||
| Q3 25 | $21.6M | $-36.0M | ||
| Q2 25 | $-148.4M | $-40.7M | ||
| Q1 25 | $-67.6M | $-48.4M | ||
| Q4 24 | $14.0M | — | ||
| Q3 24 | $24.9M | $-41.7M | ||
| Q2 24 | $-10.3M | $-80.3M | ||
| Q1 24 | $-81.8M | $-53.5M |
| Q4 25 | 43.1% | 51.0% | ||
| Q3 25 | 32.9% | 59.5% | ||
| Q2 25 | 31.5% | 60.6% | ||
| Q1 25 | 28.4% | 63.6% | ||
| Q4 24 | 46.1% | 61.5% | ||
| Q3 24 | 23.1% | 64.1% | ||
| Q2 24 | 28.4% | 64.9% | ||
| Q1 24 | 24.2% | 61.4% |
| Q4 25 | -25.8% | -54.6% | ||
| Q3 25 | 31.7% | -42.3% | ||
| Q2 25 | -38.3% | -50.3% | ||
| Q1 25 | -44.8% | -53.3% | ||
| Q4 24 | -18.0% | -62.6% | ||
| Q3 24 | 8.2% | -66.6% | ||
| Q2 24 | -33.9% | -76.0% | ||
| Q1 24 | -41.2% | -80.7% |
| Q4 25 | -21.1% | — | ||
| Q3 25 | 14.3% | -31.2% | ||
| Q2 25 | -94.7% | -37.3% | ||
| Q1 25 | -45.1% | -45.8% | ||
| Q4 24 | 7.6% | — | ||
| Q3 24 | 14.3% | -40.9% | ||
| Q2 24 | -5.7% | -80.2% | ||
| Q1 24 | -47.1% | -61.4% |
| Q4 25 | $-0.04 | $-0.05 | ||
| Q3 25 | $0.03 | $-0.03 | ||
| Q2 25 | $-0.19 | $-0.04 | ||
| Q1 25 | $-0.10 | $-0.04 | ||
| Q4 24 | $0.02 | $-0.09 | ||
| Q3 24 | $0.03 | $-0.04 | ||
| Q2 24 | $-0.01 | $-0.08 | ||
| Q1 24 | $-0.12 | $-0.05 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $364.4M | $689.6M |
| Total DebtLower is stronger | $344.0M | — |
| Stockholders' EquityBook value | $1.3B | $715.5M |
| Total Assets | $1.9B | $1.2B |
| Debt / EquityLower = less leverage | 0.27× | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $364.4M | $689.6M | ||
| Q3 25 | $412.0M | $717.2M | ||
| Q2 25 | $267.3M | $732.2M | ||
| Q1 25 | $428.8M | $757.3M | ||
| Q4 24 | $426.6M | $779.7M | ||
| Q3 24 | $400.1M | $616.1M | ||
| Q2 24 | $40.6M | $630.0M | ||
| Q1 24 | $75.6M | $650.8M |
| Q4 25 | $344.0M | — | ||
| Q3 25 | $344.2M | — | ||
| Q2 25 | $343.3M | — | ||
| Q1 25 | $439.2M | — | ||
| Q4 24 | $437.2M | — | ||
| Q3 24 | $441.0M | — | ||
| Q2 24 | $201.9M | — | ||
| Q1 24 | $350.1M | — |
| Q4 25 | $1.3B | $715.5M | ||
| Q3 25 | $1.3B | $759.9M | ||
| Q2 25 | $1.3B | $791.7M | ||
| Q1 25 | $1.3B | $810.8M | ||
| Q4 24 | $1.4B | $840.9M | ||
| Q3 24 | $1.4B | $667.7M | ||
| Q2 24 | $1.4B | $704.2M | ||
| Q1 24 | $1.3B | $762.2M |
| Q4 25 | $1.9B | $1.2B | ||
| Q3 25 | $2.0B | $1.2B | ||
| Q2 25 | $2.0B | $1.2B | ||
| Q1 25 | $2.1B | $1.2B | ||
| Q4 24 | $2.2B | $1.2B | ||
| Q3 24 | $2.3B | $985.3M | ||
| Q2 24 | $2.0B | $987.4M | ||
| Q1 24 | $2.0B | $988.4M |
| Q4 25 | 0.27× | — | ||
| Q3 25 | 0.26× | — | ||
| Q2 25 | 0.26× | — | ||
| Q1 25 | 0.33× | — | ||
| Q4 24 | 0.32× | — | ||
| Q3 24 | 0.31× | — | ||
| Q2 24 | 0.14× | — | ||
| Q1 24 | 0.28× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-25.9M | $-26.0M |
| Free Cash FlowOCF − Capex | $-28.6M | $-26.7M |
| FCF MarginFCF / Revenue | -19.3% | -21.0% |
| Capex IntensityCapex / Revenue | 1.8% | 0.5% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-190.8M | $-158.9M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-25.9M | $-26.0M | ||
| Q3 25 | $-34.6M | $-32.0M | ||
| Q2 25 | $-83.4M | $-31.0M | ||
| Q1 25 | $-34.6M | $-61.7M | ||
| Q4 24 | $-44.4M | $-55.8M | ||
| Q3 24 | $-77.1M | $-26.8M | ||
| Q2 24 | $-26.4M | $-42.2M | ||
| Q1 24 | $-35.6M | $-90.1M |
| Q4 25 | $-28.6M | $-26.7M | ||
| Q3 25 | $-37.8M | $-35.0M | ||
| Q2 25 | $-86.7M | $-33.9M | ||
| Q1 25 | $-37.7M | $-63.2M | ||
| Q4 24 | $-49.8M | $-58.4M | ||
| Q3 24 | $-85.0M | $-28.2M | ||
| Q2 24 | $-33.7M | $-42.9M | ||
| Q1 24 | $-40.0M | $-91.1M |
| Q4 25 | -19.3% | -21.0% | ||
| Q3 25 | -24.9% | -30.4% | ||
| Q2 25 | -55.3% | -31.1% | ||
| Q1 25 | -25.2% | -59.9% | ||
| Q4 24 | -27.1% | -53.8% | ||
| Q3 24 | -49.0% | -27.7% | ||
| Q2 24 | -18.5% | -42.9% | ||
| Q1 24 | -23.0% | -104.5% |
| Q4 25 | 1.8% | 0.5% | ||
| Q3 25 | 2.1% | 2.6% | ||
| Q2 25 | 2.1% | 2.6% | ||
| Q1 25 | 2.1% | 1.5% | ||
| Q4 24 | 2.9% | 2.4% | ||
| Q3 24 | 4.6% | 1.3% | ||
| Q2 24 | 4.0% | 0.7% | ||
| Q1 24 | 2.6% | 1.1% |
| Q4 25 | — | — | ||
| Q3 25 | -1.60× | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | -3.17× | — | ||
| Q3 24 | -3.10× | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
OPK
| Services | $71.1M | 48% |
| Transfer Of Intellectual Property And Other | $33.7M | 23% |
| IE | $22.1M | 15% |
| Rayaldee | $8.8M | 6% |
| Barda Agreement | $6.8M | 5% |
| MX | $6.3M | 4% |
ZLAB
| Zejula | $56.0M | 44% |
| Other | $21.9M | 17% |
| Nuzyra | $16.0M | 13% |
| Optune | $11.9M | 9% |
| XACDURO | $10.7M | 8% |
| Qinlock | $9.7M | 8% |
| AUGTYRO | $836.0K | 1% |
