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Side-by-side financial comparison of OptimizeRx Corp (OPRX) and System1, Inc. (SST). Click either name above to swap in a different company.

System1, Inc. is the larger business by last-quarter revenue ($51.9M vs $32.2M, roughly 1.6× OptimizeRx Corp). OptimizeRx Corp runs the higher net margin — 15.6% vs -26.0%, a 41.5% gap on every dollar of revenue. On growth, OptimizeRx Corp posted the faster year-over-year revenue change (-0.2% vs -31.3%). Over the past eight quarters, OptimizeRx Corp's revenue compounded faster (28.0% CAGR vs -21.8%).

OptimizeRx Corp is a U.S.-headquartered digital health technology company that delivers patient engagement, medication affordability and clinical communication solutions to life sciences enterprises, healthcare providers and pharmacy partners. Its core offerings include digital medication savings tools, patient support programs, and therapeutic area-specific resources to boost medication access and treatment adherence.

System1 is an American Internet advertising company. Formerly known as OpenMail, it was founded in 2013. It describes itself as operating a "Responsive Acquisition Marketing Platform", and cites privacy as one of its principal foci, although it has been criticized for its influence on privacy-focused properties, including search engine Startpage.com. It is headquartered in Marina del Rey, California.

OPRX vs SST — Head-to-Head

Bigger by revenue
SST
SST
1.6× larger
SST
$51.9M
$32.2M
OPRX
Growing faster (revenue YoY)
OPRX
OPRX
+31.1% gap
OPRX
-0.2%
-31.3%
SST
Higher net margin
OPRX
OPRX
41.5% more per $
OPRX
15.6%
-26.0%
SST
Faster 2-yr revenue CAGR
OPRX
OPRX
Annualised
OPRX
28.0%
-21.8%
SST

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
OPRX
OPRX
SST
SST
Revenue
$32.2M
$51.9M
Net Profit
$5.0M
$-13.5M
Gross Margin
74.8%
41.0%
Operating Margin
26.6%
-33.6%
Net Margin
15.6%
-26.0%
Revenue YoY
-0.2%
-31.3%
Net Profit YoY
6535.9%
4.8%
EPS (diluted)
$0.27
$-3.58

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
OPRX
OPRX
SST
SST
Q4 25
$32.2M
$51.9M
Q3 25
$26.1M
$61.6M
Q2 25
$29.2M
$78.1M
Q1 25
$21.9M
$74.5M
Q4 24
$32.3M
$75.6M
Q3 24
$21.3M
$88.8M
Q2 24
$18.8M
$94.6M
Q1 24
$19.7M
$84.9M
Net Profit
OPRX
OPRX
SST
SST
Q4 25
$5.0M
$-13.5M
Q3 25
$779.0K
$-18.5M
Q2 25
$1.5M
$-17.5M
Q1 25
$-2.2M
$-15.9M
Q4 24
$-78.0K
$-14.2M
Q3 24
$-9.1M
$-23.6M
Q2 24
$-4.0M
$-26.4M
Q1 24
$-6.9M
$-10.5M
Gross Margin
OPRX
OPRX
SST
SST
Q4 25
74.8%
41.0%
Q3 25
67.2%
36.9%
Q2 25
63.8%
35.7%
Q1 25
60.9%
38.2%
Q4 24
68.1%
42.1%
Q3 24
63.1%
28.0%
Q2 24
62.2%
27.6%
Q1 24
62.0%
21.9%
Operating Margin
OPRX
OPRX
SST
SST
Q4 25
26.6%
-33.6%
Q3 25
7.9%
-25.3%
Q2 25
10.9%
-20.4%
Q1 25
-9.6%
-17.6%
Q4 24
11.2%
-15.7%
Q3 24
-40.2%
-24.6%
Q2 24
-19.9%
-30.8%
Q1 24
-25.5%
-30.4%
Net Margin
OPRX
OPRX
SST
SST
Q4 25
15.6%
-26.0%
Q3 25
3.0%
-30.1%
Q2 25
5.2%
-22.4%
Q1 25
-10.0%
-21.3%
Q4 24
-0.2%
-18.7%
Q3 24
-42.8%
-26.6%
Q2 24
-21.3%
-27.9%
Q1 24
-35.0%
-12.4%
EPS (diluted)
OPRX
OPRX
SST
SST
Q4 25
$0.27
$-3.58
Q3 25
$0.04
$-2.30
Q2 25
$0.08
$-2.23
Q1 25
$-0.12
$-0.21
Q4 24
$0.00
$-3.41
Q3 24
$-0.50
$-3.37
Q2 24
$-0.22
$-3.80
Q1 24
$-0.38
$-0.16

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
OPRX
OPRX
SST
SST
Cash + ST InvestmentsLiquidity on hand
$23.4M
$86.9M
Total DebtLower is stronger
$26.3M
$305.1M
Stockholders' EquityBook value
$128.3M
$30.5M
Total Assets
$176.9M
$405.0M
Debt / EquityLower = less leverage
0.20×
10.01×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
OPRX
OPRX
SST
SST
Q4 25
$23.4M
$86.9M
Q3 25
$19.5M
$54.6M
Q2 25
$16.6M
$63.6M
Q1 25
$16.6M
$43.9M
Q4 24
$13.4M
$63.6M
Q3 24
$16.1M
$69.1M
Q2 24
$75.7M
Q1 24
$69.9M
Total Debt
OPRX
OPRX
SST
SST
Q4 25
$26.3M
$305.1M
Q3 25
$28.8M
$259.2M
Q2 25
$29.3M
$263.3M
Q1 25
$33.8M
$267.4M
Q4 24
$34.3M
$255.1M
Q3 24
$36.8M
$259.2M
Q2 24
$37.3M
$263.3M
Q1 24
$37.8M
$268.6M
Stockholders' Equity
OPRX
OPRX
SST
SST
Q4 25
$128.3M
$30.5M
Q3 25
$122.3M
$42.7M
Q2 25
$119.3M
$58.2M
Q1 25
$116.3M
$67.2M
Q4 24
$117.0M
$80.3M
Q3 24
$114.5M
$90.3M
Q2 24
$121.0M
$109.4M
Q1 24
$122.5M
$131.7M
Total Assets
OPRX
OPRX
SST
SST
Q4 25
$176.9M
$405.0M
Q3 25
$170.3M
$385.2M
Q2 25
$169.3M
$429.2M
Q1 25
$167.8M
$419.2M
Q4 24
$171.2M
$459.1M
Q3 24
$165.2M
$479.3M
Q2 24
$172.9M
$511.3M
Q1 24
$176.4M
$521.1M
Debt / Equity
OPRX
OPRX
SST
SST
Q4 25
0.20×
10.01×
Q3 25
0.24×
6.07×
Q2 25
0.25×
4.53×
Q1 25
0.29×
3.98×
Q4 24
0.29×
3.18×
Q3 24
0.32×
2.87×
Q2 24
0.31×
2.41×
Q1 24
0.31×
2.04×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
OPRX
OPRX
SST
SST
Operating Cash FlowLast quarter
$7.1M
$-10.6M
Free Cash FlowOCF − Capex
$7.1M
FCF MarginFCF / Revenue
22.0%
Capex IntensityCapex / Revenue
0.0%
0.0%
Cash ConversionOCF / Net Profit
1.41×
TTM Free Cash FlowTrailing 4 quarters
$18.7M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
OPRX
OPRX
SST
SST
Q4 25
$7.1M
$-10.6M
Q3 25
$3.2M
$-2.1M
Q2 25
$4.6M
$24.5M
Q1 25
$3.9M
$-15.9M
Q4 24
$198.0K
$772.0K
Q3 24
$1.8M
$-5.0K
Q2 24
$782.0K
$10.0M
Q1 24
$2.1M
$-16.0M
Free Cash Flow
OPRX
OPRX
SST
SST
Q4 25
$7.1M
Q3 25
$3.2M
Q2 25
$4.6M
Q1 25
$3.8M
$-16.0M
Q4 24
$181.0K
Q3 24
$1.8M
$-36.0K
Q2 24
$737.0K
Q1 24
$2.1M
FCF Margin
OPRX
OPRX
SST
SST
Q4 25
22.0%
Q3 25
12.2%
Q2 25
15.6%
Q1 25
17.5%
-21.5%
Q4 24
0.6%
Q3 24
8.3%
-0.0%
Q2 24
3.9%
Q1 24
10.6%
Capex Intensity
OPRX
OPRX
SST
SST
Q4 25
0.0%
0.0%
Q3 25
0.0%
0.0%
Q2 25
0.0%
0.0%
Q1 25
0.1%
0.1%
Q4 24
0.1%
0.0%
Q3 24
0.1%
0.0%
Q2 24
0.2%
0.0%
Q1 24
0.2%
0.0%
Cash Conversion
OPRX
OPRX
SST
SST
Q4 25
1.41×
Q3 25
4.11×
Q2 25
2.98×
Q1 25
Q4 24
Q3 24
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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