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Side-by-side financial comparison of PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (PACB) and Waters Corporation (WAT). Click either name above to swap in a different company.
Waters Corporation is the larger business by last-quarter revenue ($932.4M vs $44.6M, roughly 20.9× PACIFIC BIOSCIENCES OF CALIFORNIA, INC.). Waters Corporation runs the higher net margin — 24.2% vs -90.4%, a 114.6% gap on every dollar of revenue. On growth, PACIFIC BIOSCIENCES OF CALIFORNIA, INC. posted the faster year-over-year revenue change (13.8% vs 6.8%). Over the past eight quarters, Waters Corporation's revenue compounded faster (21.0% CAGR vs 7.3%).
Pacific Biosciences of California, Inc. is an American biotechnology company founded in 2004 that develops and manufactures systems for gene sequencing and some novel real time biological observation. PacBio has two principal sequencing platforms: single-molecule real-time sequencing (SMRT), based on the properties of zero-mode waveguides and sequencing by binding (SBB) chemistry, which uses native nucleotides and scarless incorporation for DNA binding and extension.
Waters Corporation is an American company headquartered in Milford, Massachusetts that provides analytical instruments and software used for chromatography, mass spectrometry, laboratory informatics, and rheometry by the life sciences, materials, and food industries.
PACB vs WAT — Head-to-Head
Income Statement — Q4 2025 vs Q4 2025
| Metric | | |
|---|---|---|
| Revenue | $44.6M | $932.4M |
| Net Profit | $-40.4M | $225.2M |
| Gross Margin | 37.1% | 61.1% |
| Operating Margin | -92.3% | 29.0% |
| Net Margin | -90.4% | 24.2% |
| Revenue YoY | 13.8% | 6.8% |
| Net Profit YoY | -1802.7% | -2.7% |
| EPS (diluted) | $-0.11 | $3.76 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $44.6M | $932.4M | ||
| Q3 25 | $38.4M | $799.9M | ||
| Q2 25 | $39.8M | $771.3M | ||
| Q1 25 | $37.2M | $661.7M | ||
| Q4 24 | $39.2M | $872.7M | ||
| Q3 24 | $40.0M | $740.3M | ||
| Q2 24 | $36.0M | $708.5M | ||
| Q1 24 | $38.8M | $636.8M |
| Q4 25 | $-40.4M | $225.2M | ||
| Q3 25 | $-38.0M | $148.9M | ||
| Q2 25 | $-41.9M | $147.1M | ||
| Q1 25 | $-426.1M | $121.4M | ||
| Q4 24 | $2.4M | $231.4M | ||
| Q3 24 | $-60.7M | $161.5M | ||
| Q2 24 | $-173.3M | $142.7M | ||
| Q1 24 | $-78.2M | $102.2M |
| Q4 25 | 37.1% | 61.1% | ||
| Q3 25 | 41.4% | 59.0% | ||
| Q2 25 | 36.9% | 58.3% | ||
| Q1 25 | -3.7% | 58.2% | ||
| Q4 24 | 25.6% | 60.1% | ||
| Q3 24 | 25.0% | 59.3% | ||
| Q2 24 | 16.5% | 59.3% | ||
| Q1 24 | 29.1% | 58.9% |
| Q4 25 | -92.3% | 29.0% | ||
| Q3 25 | -101.1% | 24.0% | ||
| Q2 25 | -112.8% | 24.4% | ||
| Q1 25 | -1154.5% | 22.9% | ||
| Q4 24 | -390.1% | 33.5% | ||
| Q3 24 | -160.3% | 28.5% | ||
| Q2 24 | -488.3% | 26.7% | ||
| Q1 24 | -209.6% | 21.0% |
| Q4 25 | -90.4% | 24.2% | ||
| Q3 25 | -98.9% | 18.6% | ||
| Q2 25 | -105.4% | 19.1% | ||
| Q1 25 | -1146.8% | 18.3% | ||
| Q4 24 | 6.0% | 26.5% | ||
| Q3 24 | -151.9% | 21.8% | ||
| Q2 24 | -481.3% | 20.1% | ||
| Q1 24 | -201.4% | 16.0% |
| Q4 25 | $-0.11 | $3.76 | ||
| Q3 25 | $-0.13 | $2.50 | ||
| Q2 25 | $-0.14 | $2.47 | ||
| Q1 25 | $-1.44 | $2.03 | ||
| Q4 24 | $-0.44 | $3.88 | ||
| Q3 24 | $-0.22 | $2.71 | ||
| Q2 24 | $-0.64 | $2.40 | ||
| Q1 24 | $-0.29 | $1.72 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $279.5M | $587.8M |
| Total DebtLower is stronger | — | $1.4B |
| Stockholders' EquityBook value | $5.3M | $2.6B |
| Total Assets | $784.1M | $5.1B |
| Debt / EquityLower = less leverage | — | 0.55× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $279.5M | $587.8M | ||
| Q3 25 | $298.7M | $459.1M | ||
| Q2 25 | $314.7M | $367.2M | ||
| Q1 25 | $343.1M | $382.9M | ||
| Q4 24 | $389.9M | $325.4M | ||
| Q3 24 | $471.1M | $331.5M | ||
| Q2 24 | $509.8M | $327.4M | ||
| Q1 24 | $561.9M | $338.2M |
| Q4 25 | — | $1.4B | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | $1.6B | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
| Q4 25 | $5.3M | $2.6B | ||
| Q3 25 | $36.1M | $2.3B | ||
| Q2 25 | $61.5M | $2.2B | ||
| Q1 25 | $91.6M | $2.0B | ||
| Q4 24 | $506.6M | $1.8B | ||
| Q3 24 | $453.1M | $1.6B | ||
| Q2 24 | $492.7M | $1.4B | ||
| Q1 24 | $649.0M | $1.3B |
| Q4 25 | $784.1M | $5.1B | ||
| Q3 25 | $803.2M | $4.9B | ||
| Q2 25 | $825.5M | $4.7B | ||
| Q1 25 | $860.8M | $4.6B | ||
| Q4 24 | $1.3B | $4.6B | ||
| Q3 24 | $1.5B | $4.5B | ||
| Q2 24 | $1.5B | $4.4B | ||
| Q1 24 | $1.7B | $4.5B |
| Q4 25 | — | 0.55× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 0.89× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-19.1M | $164.6M |
| Free Cash FlowOCF − Capex | $-19.9M | — |
| FCF MarginFCF / Revenue | -44.6% | — |
| Capex IntensityCapex / Revenue | 1.9% | — |
| Cash ConversionOCF / Net Profit | — | 0.73× |
| TTM Free Cash FlowTrailing 4 quarters | $-114.1M | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-19.1M | $164.6M | ||
| Q3 25 | $-18.7M | $187.3M | ||
| Q2 25 | $-29.4M | $41.1M | ||
| Q1 25 | $-44.1M | $259.6M | ||
| Q4 24 | $-30.6M | $240.1M | ||
| Q3 24 | $-45.5M | $204.6M | ||
| Q2 24 | $-54.3M | $54.5M | ||
| Q1 24 | $-75.7M | $262.9M |
| Q4 25 | $-19.9M | — | ||
| Q3 25 | $-18.8M | — | ||
| Q2 25 | $-29.9M | — | ||
| Q1 25 | $-45.4M | — | ||
| Q4 24 | $-32.3M | — | ||
| Q3 24 | $-46.3M | — | ||
| Q2 24 | $-55.7M | — | ||
| Q1 24 | $-79.6M | — |
| Q4 25 | -44.6% | — | ||
| Q3 25 | -48.9% | — | ||
| Q2 25 | -75.3% | — | ||
| Q1 25 | -122.3% | — | ||
| Q4 24 | -82.3% | — | ||
| Q3 24 | -115.7% | — | ||
| Q2 24 | -154.8% | — | ||
| Q1 24 | -205.0% | — |
| Q4 25 | 1.9% | — | ||
| Q3 25 | 0.2% | — | ||
| Q2 25 | 1.4% | — | ||
| Q1 25 | 3.7% | — | ||
| Q4 24 | 4.1% | — | ||
| Q3 24 | 2.0% | — | ||
| Q2 24 | 4.1% | — | ||
| Q1 24 | 10.0% | — |
| Q4 25 | — | 0.73× | ||
| Q3 25 | — | 1.26× | ||
| Q2 25 | — | 0.28× | ||
| Q1 25 | — | 2.14× | ||
| Q4 24 | -12.93× | 1.04× | ||
| Q3 24 | — | 1.27× | ||
| Q2 24 | — | 0.38× | ||
| Q1 24 | — | 2.57× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
PACB
| Products | $39.0M | 87% |
| Service And Other | $5.7M | 13% |
WAT
Segment breakdown not available.
