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Side-by-side financial comparison of PUMA BIOTECHNOLOGY, INC. (PBYI) and Upland Software, Inc. (UPLD). Click either name above to swap in a different company.

PUMA BIOTECHNOLOGY, INC. is the larger business by last-quarter revenue ($75.5M vs $49.3M, roughly 1.5× Upland Software, Inc.). On growth, PUMA BIOTECHNOLOGY, INC. posted the faster year-over-year revenue change (27.7% vs -27.5%). PUMA BIOTECHNOLOGY, INC. produced more free cash flow last quarter ($14.4M vs $7.2M). Over the past eight quarters, PUMA BIOTECHNOLOGY, INC.'s revenue compounded faster (31.3% CAGR vs -16.5%).

Puma Biotechnology is a publicly traded biopharmaceutical company headquartered in Los Angeles, CA.

Upland Software, Inc. is a global provider of cloud-based enterprise work management solutions. It offers products covering project portfolio management, customer engagement, IT service management, and financial automation, serving businesses of all sizes across North America, Europe, and Asia-Pacific in tech, healthcare, and professional services sectors.

PBYI vs UPLD — Head-to-Head

Bigger by revenue
PBYI
PBYI
1.5× larger
PBYI
$75.5M
$49.3M
UPLD
Growing faster (revenue YoY)
PBYI
PBYI
+55.2% gap
PBYI
27.7%
-27.5%
UPLD
More free cash flow
PBYI
PBYI
$7.2M more FCF
PBYI
$14.4M
$7.2M
UPLD
Faster 2-yr revenue CAGR
PBYI
PBYI
Annualised
PBYI
31.3%
-16.5%
UPLD

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
PBYI
PBYI
UPLD
UPLD
Revenue
$75.5M
$49.3M
Net Profit
Gross Margin
69.3%
76.5%
Operating Margin
22.7%
14.5%
Net Margin
Revenue YoY
27.7%
-27.5%
Net Profit YoY
EPS (diluted)
$0.26
$0.01

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
PBYI
PBYI
UPLD
UPLD
Q4 25
$75.5M
$49.3M
Q3 25
$54.5M
$50.5M
Q2 25
$52.4M
$53.4M
Q1 25
$46.0M
$63.7M
Q4 24
$59.1M
$68.0M
Q3 24
$80.5M
$66.7M
Q2 24
$47.1M
$69.3M
Q1 24
$43.8M
$70.7M
Net Profit
PBYI
PBYI
UPLD
UPLD
Q4 25
Q3 25
$8.8M
$-1.1M
Q2 25
$5.9M
$-13.0M
Q1 25
$3.0M
$-25.8M
Q4 24
Q3 24
$20.3M
$-1.7M
Q2 24
$-4.5M
$-11.4M
Q1 24
$-4.8M
$-96.1M
Gross Margin
PBYI
PBYI
UPLD
UPLD
Q4 25
69.3%
76.5%
Q3 25
77.7%
76.9%
Q2 25
76.5%
74.8%
Q1 25
77.1%
71.6%
Q4 24
76.4%
70.8%
Q3 24
63.9%
70.5%
Q2 24
77.4%
70.5%
Q1 24
75.5%
70.2%
Operating Margin
PBYI
PBYI
UPLD
UPLD
Q4 25
22.7%
14.5%
Q3 25
17.6%
10.6%
Q2 25
12.7%
-13.2%
Q1 25
8.7%
-1.7%
Q4 24
22.6%
-2.9%
Q3 24
27.4%
-5.0%
Q2 24
-4.6%
-7.7%
Q1 24
-5.3%
-129.6%
Net Margin
PBYI
PBYI
UPLD
UPLD
Q4 25
Q3 25
16.2%
-2.2%
Q2 25
11.2%
-24.4%
Q1 25
6.5%
-40.6%
Q4 24
Q3 24
25.2%
-2.6%
Q2 24
-9.6%
-16.5%
Q1 24
-11.0%
-135.9%
EPS (diluted)
PBYI
PBYI
UPLD
UPLD
Q4 25
$0.26
$0.01
Q3 25
$0.17
$-0.09
Q2 25
$0.12
$-0.51
Q1 25
$0.06
$-0.97
Q4 24
$0.40
$-0.30
Q3 24
$0.41
$-0.12
Q2 24
$-0.09
$-0.47
Q1 24
$-0.10
$-3.37

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
PBYI
PBYI
UPLD
UPLD
Cash + ST InvestmentsLiquidity on hand
$97.5M
$29.4M
Total DebtLower is stronger
$22.7M
$232.4M
Stockholders' EquityBook value
$130.3M
$-48.4M
Total Assets
$216.3M
$413.2M
Debt / EquityLower = less leverage
0.17×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
PBYI
PBYI
UPLD
UPLD
Q4 25
$97.5M
$29.4M
Q3 25
$94.4M
$22.8M
Q2 25
$96.0M
$41.0M
Q1 25
$93.2M
$33.7M
Q4 24
$101.0M
$56.4M
Q3 24
$96.7M
$59.7M
Q2 24
$96.8M
$232.4M
Q1 24
$107.2M
$231.6M
Total Debt
PBYI
PBYI
UPLD
UPLD
Q4 25
$22.7M
$232.4M
Q3 25
$34.0M
Q2 25
$45.3M
Q1 25
$56.7M
Q4 24
$68.0M
$290.2M
Q3 24
$79.3M
Q2 24
$90.7M
Q1 24
$102.0M
Stockholders' Equity
PBYI
PBYI
UPLD
UPLD
Q4 25
$130.3M
$-48.4M
Q3 25
$115.3M
$-47.3M
Q2 25
$104.7M
$-42.4M
Q1 25
$97.1M
$-37.8M
Q4 24
$92.1M
$-18.3M
Q3 24
$71.1M
$907.0K
Q2 24
$48.5M
$6.5M
Q1 24
$51.0M
$20.1M
Total Assets
PBYI
PBYI
UPLD
UPLD
Q4 25
$216.3M
$413.2M
Q3 25
$202.9M
$409.1M
Q2 25
$194.9M
$441.7M
Q1 25
$196.2M
$457.0M
Q4 24
$213.3M
$529.5M
Q3 24
$220.7M
$554.9M
Q2 24
$205.0M
$739.9M
Q1 24
$214.1M
$754.9M
Debt / Equity
PBYI
PBYI
UPLD
UPLD
Q4 25
0.17×
Q3 25
0.30×
Q2 25
0.43×
Q1 25
0.58×
Q4 24
0.74×
Q3 24
1.12×
Q2 24
1.87×
Q1 24
2.00×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
PBYI
PBYI
UPLD
UPLD
Operating Cash FlowLast quarter
$14.4M
$7.3M
Free Cash FlowOCF − Capex
$14.4M
$7.2M
FCF MarginFCF / Revenue
19.1%
14.7%
Capex IntensityCapex / Revenue
0.0%
0.2%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$41.7M
$24.4M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
PBYI
PBYI
UPLD
UPLD
Q4 25
$14.4M
$7.3M
Q3 25
$9.7M
$6.9M
Q2 25
$14.1M
$3.3M
Q1 25
$3.6M
$8.3M
Q4 24
$15.6M
$9.3M
Q3 24
$11.0M
$4.3M
Q2 24
$1.0M
$5.5M
Q1 24
$11.2M
$5.1M
Free Cash Flow
PBYI
PBYI
UPLD
UPLD
Q4 25
$14.4M
$7.2M
Q3 25
$9.7M
$6.7M
Q2 25
$14.1M
$2.7M
Q1 25
$3.6M
$7.9M
Q4 24
$15.6M
$9.0M
Q3 24
$11.0M
$4.2M
Q2 24
$1.0M
$5.2M
Q1 24
$4.9M
FCF Margin
PBYI
PBYI
UPLD
UPLD
Q4 25
19.1%
14.7%
Q3 25
17.7%
13.2%
Q2 25
26.8%
5.0%
Q1 25
7.7%
12.4%
Q4 24
26.4%
13.3%
Q3 24
13.7%
6.3%
Q2 24
2.1%
7.5%
Q1 24
7.0%
Capex Intensity
PBYI
PBYI
UPLD
UPLD
Q4 25
0.0%
0.2%
Q3 25
0.0%
0.4%
Q2 25
0.0%
1.2%
Q1 25
0.1%
0.7%
Q4 24
0.0%
0.5%
Q3 24
0.0%
0.2%
Q2 24
0.0%
0.4%
Q1 24
0.0%
0.3%
Cash Conversion
PBYI
PBYI
UPLD
UPLD
Q4 25
Q3 25
1.10×
Q2 25
2.41×
Q1 25
1.21×
Q4 24
Q3 24
0.54×
Q2 24
Q1 24

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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