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Side-by-side financial comparison of Principal Financial Group (PFG) and Vertex Pharmaceuticals (VRTX). Click either name above to swap in a different company.

Principal Financial Group is the larger business by last-quarter revenue ($4.6B vs $3.2B, roughly 1.4× Vertex Pharmaceuticals). Vertex Pharmaceuticals runs the higher net margin — 37.3% vs 11.3%, a 26.0% gap on every dollar of revenue. On growth, Vertex Pharmaceuticals posted the faster year-over-year revenue change (9.5% vs -3.7%). Over the past eight quarters, Vertex Pharmaceuticals's revenue compounded faster (8.9% CAGR vs 6.3%).

Principal Financial Group, Inc. (PFG) is an American global financial investment management and insurance company headquartered in Des Moines, Iowa, United States.

Vertex Pharmaceuticals Incorporated is an American biopharmaceutical company based in Boston, Massachusetts. It was one of the first biotech firms to use an explicit strategy of rational drug design rather than combinatorial chemistry. It maintains headquarters in Boston, Massachusetts, and three research facilities, in San Diego, California, and Milton Park, Oxfordshire, England.

PFG vs VRTX — Head-to-Head

Bigger by revenue
PFG
PFG
1.4× larger
PFG
$4.6B
$3.2B
VRTX
Growing faster (revenue YoY)
VRTX
VRTX
+13.2% gap
VRTX
9.5%
-3.7%
PFG
Higher net margin
VRTX
VRTX
26.0% more per $
VRTX
37.3%
11.3%
PFG
Faster 2-yr revenue CAGR
VRTX
VRTX
Annualised
VRTX
8.9%
6.3%
PFG

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
PFG
PFG
VRTX
VRTX
Revenue
$4.6B
$3.2B
Net Profit
$517.0M
$1.2B
Gross Margin
85.4%
Operating Margin
37.8%
Net Margin
11.3%
37.3%
Revenue YoY
-3.7%
9.5%
Net Profit YoY
-42.9%
30.5%
EPS (diluted)
$2.30
$4.64

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
PFG
PFG
VRTX
VRTX
Q4 25
$4.6B
$3.2B
Q3 25
$3.7B
$3.1B
Q2 25
$3.7B
$3.0B
Q1 25
$3.7B
$2.8B
Q4 24
$4.8B
$2.9B
Q3 24
$3.0B
$2.8B
Q2 24
$4.3B
$2.6B
Q1 24
$4.1B
$2.7B
Net Profit
PFG
PFG
VRTX
VRTX
Q4 25
$517.0M
$1.2B
Q3 25
$213.8M
$1.1B
Q2 25
$406.2M
$1.0B
Q1 25
$48.1M
$646.3M
Q4 24
$905.4M
$913.0M
Q3 24
$-220.0M
$1.0B
Q2 24
$353.1M
$-3.6B
Q1 24
$532.5M
$1.1B
Gross Margin
PFG
PFG
VRTX
VRTX
Q4 25
85.4%
Q3 25
86.5%
Q2 25
86.3%
Q1 25
86.9%
Q4 24
85.5%
Q3 24
85.8%
Q2 24
85.9%
Q1 24
87.3%
Operating Margin
PFG
PFG
VRTX
VRTX
Q4 25
37.8%
Q3 25
38.6%
Q2 25
38.8%
Q1 25
22.7%
Q4 24
35.2%
Q3 24
40.3%
Q2 24
-132.9%
Q1 24
42.4%
Net Margin
PFG
PFG
VRTX
VRTX
Q4 25
11.3%
37.3%
Q3 25
5.8%
35.2%
Q2 25
11.1%
34.8%
Q1 25
1.3%
23.3%
Q4 24
19.1%
31.4%
Q3 24
-7.3%
37.7%
Q2 24
8.2%
-135.8%
Q1 24
13.1%
40.9%
EPS (diluted)
PFG
PFG
VRTX
VRTX
Q4 25
$2.30
$4.64
Q3 25
$0.95
$4.20
Q2 25
$1.79
$3.99
Q1 25
$0.21
$2.49
Q4 24
$3.92
$3.62
Q3 24
$-0.95
$4.01
Q2 24
$1.49
$-13.92
Q1 24
$2.22
$4.21

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
PFG
PFG
VRTX
VRTX
Cash + ST InvestmentsLiquidity on hand
$4.4B
$6.6B
Total DebtLower is stronger
$3.9B
Stockholders' EquityBook value
$11.9B
$18.7B
Total Assets
$341.4B
$25.6B
Debt / EquityLower = less leverage
0.33×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
PFG
PFG
VRTX
VRTX
Q4 25
$4.4B
$6.6B
Q3 25
$5.1B
$6.3B
Q2 25
$3.7B
$6.4B
Q1 25
$3.9B
$6.2B
Q4 24
$4.2B
$6.1B
Q3 24
$6.2B
$6.5B
Q2 24
$4.8B
$5.8B
Q1 24
$4.2B
$10.2B
Total Debt
PFG
PFG
VRTX
VRTX
Q4 25
$3.9B
Q3 25
$3.9B
Q2 25
$3.9B
Q1 25
$4.3B
Q4 24
$4.0B
Q3 24
$3.9B
Q2 24
$3.9B
Q1 24
$3.9B
Stockholders' Equity
PFG
PFG
VRTX
VRTX
Q4 25
$11.9B
$18.7B
Q3 25
$11.7B
$17.3B
Q2 25
$11.4B
$17.2B
Q1 25
$11.2B
$16.5B
Q4 24
$11.1B
$16.4B
Q3 24
$11.2B
$15.6B
Q2 24
$11.0B
$14.8B
Q1 24
$11.2B
$18.5B
Total Assets
PFG
PFG
VRTX
VRTX
Q4 25
$341.4B
$25.6B
Q3 25
$334.5B
$24.9B
Q2 25
$323.1B
$24.0B
Q1 25
$313.0B
$22.9B
Q4 24
$313.7B
$22.5B
Q3 24
$322.9B
$22.2B
Q2 24
$308.8B
$20.1B
Q1 24
$308.7B
$23.9B
Debt / Equity
PFG
PFG
VRTX
VRTX
Q4 25
0.33×
Q3 25
0.34×
Q2 25
0.34×
Q1 25
0.39×
Q4 24
0.36×
Q3 24
0.35×
Q2 24
0.36×
Q1 24
0.35×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
PFG
PFG
VRTX
VRTX
Operating Cash FlowLast quarter
$1.7B
$498.0M
Free Cash FlowOCF − Capex
$348.6M
FCF MarginFCF / Revenue
10.9%
Capex IntensityCapex / Revenue
4.7%
Cash ConversionOCF / Net Profit
3.37×
0.42×
TTM Free Cash FlowTrailing 4 quarters
$3.2B

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
PFG
PFG
VRTX
VRTX
Q4 25
$1.7B
$498.0M
Q3 25
$1.0B
$1.2B
Q2 25
$811.9M
$1.1B
Q1 25
$977.3M
$818.9M
Q4 24
$1.5B
$584.6M
Q3 24
$1.1B
$1.4B
Q2 24
$1.4B
$-3.8B
Q1 24
$584.2M
$1.3B
Free Cash Flow
PFG
PFG
VRTX
VRTX
Q4 25
$348.6M
Q3 25
$1.1B
Q2 25
$927.4M
Q1 25
$778.2M
Q4 24
$492.0M
Q3 24
$1.3B
Q2 24
$-3.8B
Q1 24
$1.2B
FCF Margin
PFG
PFG
VRTX
VRTX
Q4 25
10.9%
Q3 25
37.0%
Q2 25
31.3%
Q1 25
28.1%
Q4 24
16.9%
Q3 24
47.0%
Q2 24
-144.5%
Q1 24
46.0%
Capex Intensity
PFG
PFG
VRTX
VRTX
Q4 25
4.7%
Q3 25
3.3%
Q2 25
4.9%
Q1 25
1.5%
Q4 24
3.2%
Q3 24
2.4%
Q2 24
2.6%
Q1 24
2.5%
Cash Conversion
PFG
PFG
VRTX
VRTX
Q4 25
3.37×
0.42×
Q3 25
4.70×
1.15×
Q2 25
2.00×
1.04×
Q1 25
20.32×
1.27×
Q4 24
1.61×
0.64×
Q3 24
1.31×
Q2 24
4.05×
Q1 24
1.10×
1.19×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

PFG
PFG

Segment Retirement And Income Solutions$1.6B36%
Segment Benefits And Protection$1.1B23%
Other$582.8M13%
Segment Principal Asset Management$465.6M10%
Subsegment Investment Management$449.4M10%
Administrative Service$152.2M3%
Subsegment International Pension$91.2M2%
Segment Corporate$73.0M2%
Subsegment Life Insurance$26.1M1%
Financial Service Other$25.1M1%
Residential Mortgage$7.4M0%
Subsegment Specialty Benefits$3.7M0%
Deposit Account$3.4M0%
Commission Income$1.8M0%

VRTX
VRTX

TRIKAFTAKAFTRIO$2.6B81%
ALYFTREK$380.1M12%
Manufactured Product Other$237.4M7%

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