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Side-by-side financial comparison of PTC THERAPEUTICS, INC. (PTCT) and Portillo's Inc. (PTLO). Click either name above to swap in a different company.

Portillo's Inc. is the larger business by last-quarter revenue ($185.7M vs $164.7M, roughly 1.1× PTC THERAPEUTICS, INC.). Portillo's Inc. runs the higher net margin — 3.4% vs -82.0%, a 85.3% gap on every dollar of revenue. On growth, Portillo's Inc. posted the faster year-over-year revenue change (0.6% vs -22.7%). Portillo's Inc. produced more free cash flow last quarter ($-9.2M vs $-36.6M). Over the past eight quarters, Portillo's Inc.'s revenue compounded faster (5.8% CAGR vs -11.5%).

PTC Therapeutics, Inc. is a US pharmaceutical company focused on the development of orally administered small molecule drugs and gene therapy which regulate gene expression by targeting post-transcriptional control (PTC) mechanisms in orphan diseases.

Portillo's Restaurant Group, Inc. is an American fast casual restaurant chain based in the Chicago area that specializes in serving Chicago-style food such as hot dogs, Maxwell Street Polish, and Italian beef. The company was founded by Dick Portillo on April 9, 1963, in Villa Park, Illinois, under the name "The Dog House".

PTCT vs PTLO — Head-to-Head

Bigger by revenue
PTLO
PTLO
1.1× larger
PTLO
$185.7M
$164.7M
PTCT
Growing faster (revenue YoY)
PTLO
PTLO
+23.4% gap
PTLO
0.6%
-22.7%
PTCT
Higher net margin
PTLO
PTLO
85.3% more per $
PTLO
3.4%
-82.0%
PTCT
More free cash flow
PTLO
PTLO
$27.5M more FCF
PTLO
$-9.2M
$-36.6M
PTCT
Faster 2-yr revenue CAGR
PTLO
PTLO
Annualised
PTLO
5.8%
-11.5%
PTCT

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
PTCT
PTCT
PTLO
PTLO
Revenue
$164.7M
$185.7M
Net Profit
$-135.0M
$6.3M
Gross Margin
Operating Margin
-43.3%
5.6%
Net Margin
-82.0%
3.4%
Revenue YoY
-22.7%
0.6%
Net Profit YoY
-104.8%
-49.5%
EPS (diluted)
$-1.63
$0.08

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
PTCT
PTCT
PTLO
PTLO
Q4 25
$164.7M
$185.7M
Q3 25
$211.0M
$181.4M
Q2 25
$178.9M
$188.5M
Q1 25
$1.2B
$176.4M
Q4 24
$213.2M
$184.6M
Q3 24
$196.8M
$178.3M
Q2 24
$186.7M
$181.9M
Q1 24
$210.1M
$165.8M
Net Profit
PTCT
PTCT
PTLO
PTLO
Q4 25
$-135.0M
$6.3M
Q3 25
$15.9M
$1.2M
Q2 25
$-64.8M
$8.7M
Q1 25
$866.6M
$3.3M
Q4 24
$-65.9M
$12.4M
Q3 24
$-106.7M
$7.2M
Q2 24
$-99.2M
$6.5M
Q1 24
$-91.6M
$4.6M
Operating Margin
PTCT
PTCT
PTLO
PTLO
Q4 25
-43.3%
5.6%
Q3 25
1.4%
3.0%
Q2 25
-19.5%
9.3%
Q1 25
82.5%
5.9%
Q4 24
-76.2%
7.5%
Q3 24
-27.7%
9.0%
Q2 24
-21.5%
10.0%
Q1 24
-21.6%
6.1%
Net Margin
PTCT
PTCT
PTLO
PTLO
Q4 25
-82.0%
3.4%
Q3 25
7.5%
0.7%
Q2 25
-36.3%
4.6%
Q1 25
73.7%
1.9%
Q4 24
-30.9%
6.7%
Q3 24
-54.2%
4.1%
Q2 24
-53.1%
3.6%
Q1 24
-43.6%
2.8%
EPS (diluted)
PTCT
PTCT
PTLO
PTLO
Q4 25
$-1.63
$0.08
Q3 25
$0.20
$0.02
Q2 25
$-0.83
$0.12
Q1 25
$10.04
$0.05
Q4 24
$-0.85
$0.17
Q3 24
$-1.39
$0.11
Q2 24
$-1.29
$0.10
Q1 24
$-1.20
$0.08

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
PTCT
PTCT
PTLO
PTLO
Cash + ST InvestmentsLiquidity on hand
$1.9B
Total DebtLower is stronger
$334.2M
Stockholders' EquityBook value
$-205.3M
$467.8M
Total Assets
$2.9B
$1.6B
Debt / EquityLower = less leverage
0.71×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
PTCT
PTCT
PTLO
PTLO
Q4 25
$1.9B
Q3 25
$1.7B
Q2 25
$2.0B
Q1 25
$2.0B
Q4 24
$1.1B
Q3 24
$1.0B
Q2 24
$1.1B
Q1 24
$884.8M
Total Debt
PTCT
PTCT
PTLO
PTLO
Q4 25
$334.2M
Q3 25
$322.6M
Q2 25
$317.0M
Q1 25
$319.8M
Q4 24
$311.7M
Q3 24
$302.2M
Q2 24
$305.1M
Q1 24
$321.7M
Stockholders' Equity
PTCT
PTCT
PTLO
PTLO
Q4 25
$-205.3M
$467.8M
Q3 25
$-155.8M
$459.4M
Q2 25
$-206.5M
$458.9M
Q1 25
$-185.8M
$406.9M
Q4 24
$-1.1B
$401.1M
Q3 24
$-1.1B
$382.4M
Q2 24
$-980.2M
$370.2M
Q1 24
$-893.9M
$360.5M
Total Assets
PTCT
PTCT
PTLO
PTLO
Q4 25
$2.9B
$1.6B
Q3 25
$2.6B
$1.6B
Q2 25
$2.6B
$1.6B
Q1 25
$2.7B
$1.5B
Q4 24
$1.7B
$1.5B
Q3 24
$1.8B
$1.5B
Q2 24
$1.9B
$1.4B
Q1 24
$1.8B
$1.4B
Debt / Equity
PTCT
PTCT
PTLO
PTLO
Q4 25
0.71×
Q3 25
0.70×
Q2 25
0.69×
Q1 25
0.79×
Q4 24
0.78×
Q3 24
0.79×
Q2 24
0.82×
Q1 24
0.89×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
PTCT
PTCT
PTLO
PTLO
Operating Cash FlowLast quarter
$-34.3M
$23.2M
Free Cash FlowOCF − Capex
$-36.6M
$-9.2M
FCF MarginFCF / Revenue
-22.3%
-4.9%
Capex IntensityCapex / Revenue
1.4%
17.4%
Cash ConversionOCF / Net Profit
3.69×
TTM Free Cash FlowTrailing 4 quarters
$702.3M
$-18.5M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
PTCT
PTCT
PTLO
PTLO
Q4 25
$-34.3M
$23.2M
Q3 25
$-66.3M
$20.0M
Q2 25
$-58.3M
$19.2M
Q1 25
$870.1M
$9.4M
Q4 24
$-30.0M
$26.1M
Q3 24
$-77.0M
$30.3M
Q2 24
$-71.5M
$32.6M
Q1 24
$70.8M
$9.1M
Free Cash Flow
PTCT
PTCT
PTLO
PTLO
Q4 25
$-36.6M
$-9.2M
Q3 25
$-69.7M
$-5.0M
Q2 25
$-59.6M
$5.2M
Q1 25
$868.4M
$-9.6M
Q4 24
$-33.8M
$-5.6M
Q3 24
$-77.5M
$7.7M
Q2 24
$-78.8M
$15.6M
Q1 24
$61.2M
$-7.9M
FCF Margin
PTCT
PTCT
PTLO
PTLO
Q4 25
-22.3%
-4.9%
Q3 25
-33.1%
-2.7%
Q2 25
-33.3%
2.8%
Q1 25
73.8%
-5.4%
Q4 24
-15.8%
-3.0%
Q3 24
-39.4%
4.3%
Q2 24
-42.2%
8.6%
Q1 24
29.1%
-4.7%
Capex Intensity
PTCT
PTCT
PTLO
PTLO
Q4 25
1.4%
17.4%
Q3 25
1.6%
13.8%
Q2 25
0.7%
7.5%
Q1 25
0.1%
10.8%
Q4 24
1.8%
17.2%
Q3 24
0.3%
12.7%
Q2 24
4.0%
9.3%
Q1 24
4.6%
10.2%
Cash Conversion
PTCT
PTCT
PTLO
PTLO
Q4 25
3.69×
Q3 25
-4.17×
16.51×
Q2 25
2.21×
Q1 25
1.00×
2.85×
Q4 24
2.10×
Q3 24
4.20×
Q2 24
5.03×
Q1 24
1.99×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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