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Side-by-side financial comparison of RHYTHM PHARMACEUTICALS, INC. (RYTM) and SMARTFINANCIAL INC. (SMBK). Click either name above to swap in a different company.
RHYTHM PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($57.3M vs $53.8M, roughly 1.1× SMARTFINANCIAL INC.). SMARTFINANCIAL INC. runs the higher net margin — 25.4% vs -83.0%, a 108.4% gap on every dollar of revenue. Over the past eight quarters, RHYTHM PHARMACEUTICALS, INC.'s revenue compounded faster (48.5% CAGR vs 15.4%).
Rhythm Pharmaceuticals is a biopharmaceutical firm focused on developing and commercializing targeted therapies for rare genetic disorders causing severe unmanageable obesity, including POMC deficiency, LEPR deficiency, and Bardet-Biedl syndrome. It serves patients in North America and Europe who lack effective standard treatments for their chronic life-altering conditions.
SmartFinancial Inc. is a U.S.-based bank holding company that operates its wholly owned subsidiary SmartBank. It offers a full range of retail and commercial banking products including deposit accounts, personal and business loans, mortgage services, and wealth management solutions, primarily serving individual customers and small-to-medium enterprises across the Southeastern United States.
RYTM vs SMBK — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $57.3M | $53.8M |
| Net Profit | $-47.5M | $13.7M |
| Gross Margin | 91.6% | — |
| Operating Margin | -82.2% | — |
| Net Margin | -83.0% | 25.4% |
| Revenue YoY | 36.9% | — |
| Net Profit YoY | -9.6% | 21.6% |
| EPS (diluted) | $-0.73 | $0.81 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q1 26 | — | $53.8M | ||
| Q4 25 | $57.3M | $53.3M | ||
| Q3 25 | $51.3M | $51.1M | ||
| Q2 25 | $48.5M | $49.2M | ||
| Q1 25 | $32.7M | $46.8M | ||
| Q4 24 | $41.8M | $46.8M | ||
| Q3 24 | $33.3M | $44.2M | ||
| Q2 24 | $29.1M | $40.4M |
| Q1 26 | — | $13.7M | ||
| Q4 25 | $-47.5M | $13.7M | ||
| Q3 25 | $-52.9M | $13.7M | ||
| Q2 25 | $-46.6M | $11.7M | ||
| Q1 25 | $-49.5M | $11.3M | ||
| Q4 24 | $-43.3M | $9.6M | ||
| Q3 24 | $-43.6M | $9.1M | ||
| Q2 24 | $-32.3M | $8.0M |
| Q1 26 | — | — | ||
| Q4 25 | 91.6% | — | ||
| Q3 25 | 89.3% | — | ||
| Q2 25 | 88.6% | — | ||
| Q1 25 | 88.8% | — | ||
| Q4 24 | 90.9% | — | ||
| Q3 24 | 88.5% | — | ||
| Q2 24 | 89.9% | — |
| Q1 26 | — | — | ||
| Q4 25 | -82.2% | 31.3% | ||
| Q3 25 | -102.6% | 33.2% | ||
| Q2 25 | -93.4% | 29.0% | ||
| Q1 25 | -143.7% | 29.0% | ||
| Q4 24 | -98.6% | 26.5% | ||
| Q3 24 | -132.0% | 24.3% | ||
| Q2 24 | -139.2% | 25.6% |
| Q1 26 | — | 25.4% | ||
| Q4 25 | -83.0% | 25.7% | ||
| Q3 25 | -103.1% | 26.8% | ||
| Q2 25 | -96.1% | 23.8% | ||
| Q1 25 | -151.4% | 24.0% | ||
| Q4 24 | -103.6% | 20.6% | ||
| Q3 24 | -131.2% | 20.7% | ||
| Q2 24 | -110.9% | 19.8% |
| Q1 26 | — | $0.81 | ||
| Q4 25 | $-0.73 | $0.81 | ||
| Q3 25 | $-0.82 | $0.81 | ||
| Q2 25 | $-0.75 | $0.69 | ||
| Q1 25 | $-0.81 | $0.67 | ||
| Q4 24 | $-0.71 | $0.57 | ||
| Q3 24 | $-0.73 | $0.54 | ||
| Q2 24 | $-0.55 | $0.48 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $388.9M | $346.1M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $139.1M | $562.2M |
| Total Assets | $480.2M | $5.9B |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | $346.1M | ||
| Q4 25 | $388.9M | $464.4M | ||
| Q3 25 | $416.1M | $557.1M | ||
| Q2 25 | $291.0M | $365.1M | ||
| Q1 25 | $314.5M | $423.0M | ||
| Q4 24 | $320.6M | $387.6M | ||
| Q3 24 | $298.4M | $192.9M | ||
| Q2 24 | $319.1M | $342.8M |
| Q1 26 | — | — | ||
| Q4 25 | — | — | ||
| Q3 25 | — | $1.3M | ||
| Q2 25 | — | $7.0M | ||
| Q1 25 | — | $7.6M | ||
| Q4 24 | — | $8.1M | ||
| Q3 24 | — | $9.0M | ||
| Q2 24 | — | $12.7M |
| Q1 26 | — | $562.2M | ||
| Q4 25 | $139.1M | $552.4M | ||
| Q3 25 | $148.8M | $538.4M | ||
| Q2 25 | $-11.9M | $519.0M | ||
| Q1 25 | $18.9M | $505.8M | ||
| Q4 24 | $21.7M | $491.3M | ||
| Q3 24 | $11.2M | $489.0M | ||
| Q2 24 | $39.3M | $472.5M |
| Q1 26 | — | $5.9B | ||
| Q4 25 | $480.2M | $5.9B | ||
| Q3 25 | $506.9M | $5.8B | ||
| Q2 25 | $372.7M | $5.5B | ||
| Q1 25 | $386.7M | $5.4B | ||
| Q4 24 | $392.3M | $5.3B | ||
| Q3 24 | $363.6M | $4.9B | ||
| Q2 24 | $381.8M | $4.9B |
| Q1 26 | — | — | ||
| Q4 25 | — | — | ||
| Q3 25 | — | 0.00× | ||
| Q2 25 | — | 0.01× | ||
| Q1 25 | — | 0.02× | ||
| Q4 24 | — | 0.02× | ||
| Q3 24 | — | 0.02× | ||
| Q2 24 | — | 0.03× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-25.4M | — |
| Free Cash FlowOCF − Capex | — | — |
| FCF MarginFCF / Revenue | — | — |
| Capex IntensityCapex / Revenue | — | — |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q1 26 | — | — | ||
| Q4 25 | $-25.4M | $61.7M | ||
| Q3 25 | $-26.6M | $16.9M | ||
| Q2 25 | $-23.3M | $14.0M | ||
| Q1 25 | $-40.4M | $14.3M | ||
| Q4 24 | $-18.8M | $52.7M | ||
| Q3 24 | $-25.2M | $12.4M | ||
| Q2 24 | $-29.1M | $16.5M |
| Q1 26 | — | — | ||
| Q4 25 | — | $59.3M | ||
| Q3 25 | — | $16.6M | ||
| Q2 25 | — | $13.2M | ||
| Q1 25 | — | $13.4M | ||
| Q4 24 | — | $46.3M | ||
| Q3 24 | — | $11.3M | ||
| Q2 24 | — | $15.4M |
| Q1 26 | — | — | ||
| Q4 25 | — | 111.3% | ||
| Q3 25 | — | 32.4% | ||
| Q2 25 | — | 26.9% | ||
| Q1 25 | — | 28.5% | ||
| Q4 24 | — | 98.9% | ||
| Q3 24 | — | 25.7% | ||
| Q2 24 | — | 38.2% |
| Q1 26 | — | — | ||
| Q4 25 | — | 4.5% | ||
| Q3 25 | — | 0.6% | ||
| Q2 25 | — | 1.6% | ||
| Q1 25 | — | 2.0% | ||
| Q4 24 | — | 13.7% | ||
| Q3 24 | — | 2.4% | ||
| Q2 24 | — | 2.7% |
| Q1 26 | — | — | ||
| Q4 25 | — | 4.50× | ||
| Q3 25 | — | 1.23× | ||
| Q2 25 | — | 1.20× | ||
| Q1 25 | — | 1.27× | ||
| Q4 24 | — | 5.47× | ||
| Q3 24 | — | 1.36× | ||
| Q2 24 | — | 2.07× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
RYTM
Segment breakdown not available.
SMBK
| Net Interest Income | $45.9M | 85% |
| Noninterest Income | $7.9M | 15% |
