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Side-by-side financial comparison of RHYTHM PHARMACEUTICALS, INC. (RYTM) and Spok Holdings, Inc (SPOK). Click either name above to swap in a different company.
RHYTHM PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($57.3M vs $33.9M, roughly 1.7× Spok Holdings, Inc). Spok Holdings, Inc runs the higher net margin — 8.7% vs -83.0%, a 91.6% gap on every dollar of revenue. On growth, RHYTHM PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (36.9% vs -0.1%). Over the past eight quarters, RHYTHM PHARMACEUTICALS, INC.'s revenue compounded faster (48.5% CAGR vs -1.5%).
Rhythm Pharmaceuticals is a biopharmaceutical firm focused on developing and commercializing targeted therapies for rare genetic disorders causing severe unmanageable obesity, including POMC deficiency, LEPR deficiency, and Bardet-Biedl syndrome. It serves patients in North America and Europe who lack effective standard treatments for their chronic life-altering conditions.
Spok Holdings, Inc. is a global provider of critical communication solutions primarily serving the healthcare industry. It offers unified clinical communication platforms, secure messaging tools, alerting systems, and on-call scheduling software that help care teams coordinate efficiently, cut response times, and boost patient safety across medical facilities.
RYTM vs SPOK — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $57.3M | $33.9M |
| Net Profit | $-47.5M | $2.9M |
| Gross Margin | 91.6% | 76.7% |
| Operating Margin | -82.2% | 11.6% |
| Net Margin | -83.0% | 8.7% |
| Revenue YoY | 36.9% | -0.1% |
| Net Profit YoY | -9.6% | -19.6% |
| EPS (diluted) | $-0.73 | $0.13 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $57.3M | $33.9M | ||
| Q3 25 | $51.3M | $33.9M | ||
| Q2 25 | $48.5M | $35.7M | ||
| Q1 25 | $32.7M | $36.3M | ||
| Q4 24 | $41.8M | $33.9M | ||
| Q3 24 | $33.3M | $34.9M | ||
| Q2 24 | $29.1M | $34.0M | ||
| Q1 24 | $26.0M | $34.9M |
| Q4 25 | $-47.5M | $2.9M | ||
| Q3 25 | $-52.9M | $3.2M | ||
| Q2 25 | $-46.6M | $4.6M | ||
| Q1 25 | $-49.5M | $5.2M | ||
| Q4 24 | $-43.3M | $3.6M | ||
| Q3 24 | $-43.6M | $3.7M | ||
| Q2 24 | $-32.3M | $3.4M | ||
| Q1 24 | $-141.4M | $4.2M |
| Q4 25 | 91.6% | 76.7% | ||
| Q3 25 | 89.3% | 78.3% | ||
| Q2 25 | 88.6% | 79.5% | ||
| Q1 25 | 88.8% | 80.1% | ||
| Q4 24 | 90.9% | 78.5% | ||
| Q3 24 | 88.5% | 79.5% | ||
| Q2 24 | 89.9% | 78.9% | ||
| Q1 24 | 89.2% | 79.5% |
| Q4 25 | -82.2% | 11.6% | ||
| Q3 25 | -102.6% | 12.9% | ||
| Q2 25 | -93.4% | 15.1% | ||
| Q1 25 | -143.7% | 16.6% | ||
| Q4 24 | -98.6% | 13.7% | ||
| Q3 24 | -132.0% | 14.2% | ||
| Q2 24 | -139.2% | 13.2% | ||
| Q1 24 | -538.7% | 14.0% |
| Q4 25 | -83.0% | 8.7% | ||
| Q3 25 | -103.1% | 9.5% | ||
| Q2 25 | -96.1% | 12.8% | ||
| Q1 25 | -151.4% | 14.3% | ||
| Q4 24 | -103.6% | 10.8% | ||
| Q3 24 | -131.2% | 10.5% | ||
| Q2 24 | -110.9% | 10.1% | ||
| Q1 24 | -544.4% | 12.1% |
| Q4 25 | $-0.73 | $0.13 | ||
| Q3 25 | $-0.82 | $0.15 | ||
| Q2 25 | $-0.75 | $0.22 | ||
| Q1 25 | $-0.81 | $0.25 | ||
| Q4 24 | $-0.71 | $0.17 | ||
| Q3 24 | $-0.73 | $0.18 | ||
| Q2 24 | $-0.55 | $0.17 | ||
| Q1 24 | $-2.35 | $0.21 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $388.9M | $25.3M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $139.1M | $146.4M |
| Total Assets | $480.2M | $206.1M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $388.9M | $25.3M | ||
| Q3 25 | $416.1M | $21.4M | ||
| Q2 25 | $291.0M | $20.2M | ||
| Q1 25 | $314.5M | $19.9M | ||
| Q4 24 | $320.6M | $29.1M | ||
| Q3 24 | $298.4M | $27.8M | ||
| Q2 24 | $319.1M | $23.9M | ||
| Q1 24 | $201.2M | $23.3M |
| Q4 25 | $139.1M | $146.4M | ||
| Q3 25 | $148.8M | $148.7M | ||
| Q2 25 | $-11.9M | $150.9M | ||
| Q1 25 | $18.9M | $151.7M | ||
| Q4 24 | $21.7M | $154.7M | ||
| Q3 24 | $11.2M | $156.3M | ||
| Q2 24 | $39.3M | $158.2M | ||
| Q1 24 | $61.6M | $160.2M |
| Q4 25 | $480.2M | $206.1M | ||
| Q3 25 | $506.9M | $209.7M | ||
| Q2 25 | $372.7M | $208.7M | ||
| Q1 25 | $386.7M | $204.5M | ||
| Q4 24 | $392.3M | $217.1M | ||
| Q3 24 | $363.6M | $216.8M | ||
| Q2 24 | $381.8M | $216.4M | ||
| Q1 24 | $258.7M | $215.0M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-25.4M | $11.5M |
| Free Cash FlowOCF − Capex | — | $10.1M |
| FCF MarginFCF / Revenue | — | 29.9% |
| Capex IntensityCapex / Revenue | — | 4.1% |
| Cash ConversionOCF / Net Profit | — | 3.93× |
| TTM Free Cash FlowTrailing 4 quarters | — | $25.2M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-25.4M | $11.5M | ||
| Q3 25 | $-26.6M | $8.1M | ||
| Q2 25 | $-23.3M | $7.0M | ||
| Q1 25 | $-40.4M | $2.3M | ||
| Q4 24 | $-18.8M | $8.4M | ||
| Q3 24 | $-25.2M | $11.1M | ||
| Q2 24 | $-29.1M | $7.4M | ||
| Q1 24 | $-40.7M | $2.0M |
| Q4 25 | — | $10.1M | ||
| Q3 25 | — | $7.6M | ||
| Q2 25 | — | $6.0M | ||
| Q1 25 | — | $1.5M | ||
| Q4 24 | — | $7.5M | ||
| Q3 24 | — | $10.3M | ||
| Q2 24 | — | $6.8M | ||
| Q1 24 | — | $1.1M |
| Q4 25 | — | 29.9% | ||
| Q3 25 | — | 22.4% | ||
| Q2 25 | — | 16.8% | ||
| Q1 25 | — | 4.2% | ||
| Q4 24 | — | 22.3% | ||
| Q3 24 | — | 29.4% | ||
| Q2 24 | — | 20.0% | ||
| Q1 24 | — | 3.2% |
| Q4 25 | — | 4.1% | ||
| Q3 25 | — | 1.6% | ||
| Q2 25 | — | 2.9% | ||
| Q1 25 | — | 2.1% | ||
| Q4 24 | — | 2.5% | ||
| Q3 24 | — | 2.4% | ||
| Q2 24 | — | 1.9% | ||
| Q1 24 | — | 2.5% |
| Q4 25 | — | 3.93× | ||
| Q3 25 | — | 2.54× | ||
| Q2 25 | — | 1.55× | ||
| Q1 25 | — | 0.43× | ||
| Q4 24 | — | 2.31× | ||
| Q3 24 | — | 3.03× | ||
| Q2 24 | — | 2.17× | ||
| Q1 24 | — | 0.47× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
RYTM
Segment breakdown not available.
SPOK
| Paging | $16.8M | 50% |
| Software Operations | $16.0M | 47% |
| License | $1.2M | 4% |
