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Side-by-side financial comparison of RHYTHM PHARMACEUTICALS, INC. (RYTM) and SYPRIS SOLUTIONS INC (SYPR). Click either name above to swap in a different company.
RHYTHM PHARMACEUTICALS, INC. is the larger business by last-quarter revenue ($57.3M vs $30.3M, roughly 1.9× SYPRIS SOLUTIONS INC). SYPRIS SOLUTIONS INC runs the higher net margin — -12.9% vs -83.0%, a 70.1% gap on every dollar of revenue. On growth, RHYTHM PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (36.9% vs -9.5%). Over the past eight quarters, RHYTHM PHARMACEUTICALS, INC.'s revenue compounded faster (48.5% CAGR vs -7.7%).
Rhythm Pharmaceuticals is a biopharmaceutical firm focused on developing and commercializing targeted therapies for rare genetic disorders causing severe unmanageable obesity, including POMC deficiency, LEPR deficiency, and Bardet-Biedl syndrome. It serves patients in North America and Europe who lack effective standard treatments for their chronic life-altering conditions.
Sypris Solutions Inc. is a U.S.-headquartered provider of highly engineered components and specialized technical services, primarily serving aerospace, defense, automotive and commercial industrial markets. It delivers custom manufacturing, performance testing, and value-added engineering support for mission-critical systems and parts for global enterprise clients.
RYTM vs SYPR — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $57.3M | $30.3M |
| Net Profit | $-47.5M | $-3.9M |
| Gross Margin | 91.6% | 4.6% |
| Operating Margin | -82.2% | -10.9% |
| Net Margin | -83.0% | -12.9% |
| Revenue YoY | 36.9% | -9.5% |
| Net Profit YoY | -9.6% | -2992.6% |
| EPS (diluted) | $-0.73 | $-0.17 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $57.3M | $30.3M | ||
| Q3 25 | $51.3M | $28.7M | ||
| Q2 25 | $48.5M | $31.4M | ||
| Q1 25 | $32.7M | $29.5M | ||
| Q4 24 | $41.8M | $33.4M | ||
| Q3 24 | $33.3M | $35.7M | ||
| Q2 24 | $29.1M | $35.5M | ||
| Q1 24 | $26.0M | $35.6M |
| Q4 25 | $-47.5M | $-3.9M | ||
| Q3 25 | $-52.9M | $517.0K | ||
| Q2 25 | $-46.6M | $-2.1M | ||
| Q1 25 | $-49.5M | $-899.0K | ||
| Q4 24 | $-43.3M | $135.0K | ||
| Q3 24 | $-43.6M | $390.0K | ||
| Q2 24 | $-32.3M | $16.0K | ||
| Q1 24 | $-141.4M | $-2.2M |
| Q4 25 | 91.6% | 4.6% | ||
| Q3 25 | 89.3% | 7.2% | ||
| Q2 25 | 88.6% | 8.2% | ||
| Q1 25 | 88.8% | 11.4% | ||
| Q4 24 | 90.9% | 16.1% | ||
| Q3 24 | 88.5% | 16.8% | ||
| Q2 24 | 89.9% | 15.9% | ||
| Q1 24 | 89.2% | 8.1% |
| Q4 25 | -82.2% | -10.9% | ||
| Q3 25 | -102.6% | -6.1% | ||
| Q2 25 | -93.4% | -4.6% | ||
| Q1 25 | -143.7% | -0.4% | ||
| Q4 24 | -98.6% | 3.9% | ||
| Q3 24 | -132.0% | 4.8% | ||
| Q2 24 | -139.2% | 3.6% | ||
| Q1 24 | -538.7% | -3.9% |
| Q4 25 | -83.0% | -12.9% | ||
| Q3 25 | -103.1% | 1.8% | ||
| Q2 25 | -96.1% | -6.5% | ||
| Q1 25 | -151.4% | -3.0% | ||
| Q4 24 | -103.6% | 0.4% | ||
| Q3 24 | -131.2% | 1.1% | ||
| Q2 24 | -110.9% | 0.0% | ||
| Q1 24 | -544.4% | -6.2% |
| Q4 25 | $-0.73 | $-0.17 | ||
| Q3 25 | $-0.82 | $0.02 | ||
| Q2 25 | $-0.75 | $-0.09 | ||
| Q1 25 | $-0.81 | $-0.04 | ||
| Q4 24 | $-0.71 | $0.00 | ||
| Q3 24 | $-0.73 | $0.02 | ||
| Q2 24 | $-0.55 | $0.00 | ||
| Q1 24 | $-2.35 | $-0.10 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $388.9M | — |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $139.1M | $17.8M |
| Total Assets | $480.2M | $107.8M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $388.9M | — | ||
| Q3 25 | $416.1M | — | ||
| Q2 25 | $291.0M | — | ||
| Q1 25 | $314.5M | — | ||
| Q4 24 | $320.6M | — | ||
| Q3 24 | $298.4M | — | ||
| Q2 24 | $319.1M | — | ||
| Q1 24 | $201.2M | — |
| Q4 25 | $139.1M | $17.8M | ||
| Q3 25 | $148.8M | $20.0M | ||
| Q2 25 | $-11.9M | $18.7M | ||
| Q1 25 | $18.9M | $19.0M | ||
| Q4 24 | $21.7M | $19.6M | ||
| Q3 24 | $11.2M | $18.2M | ||
| Q2 24 | $39.3M | $19.0M | ||
| Q1 24 | $61.6M | $20.8M |
| Q4 25 | $480.2M | $107.8M | ||
| Q3 25 | $506.9M | $112.5M | ||
| Q2 25 | $372.7M | $105.8M | ||
| Q1 25 | $386.7M | $110.2M | ||
| Q4 24 | $392.3M | $119.4M | ||
| Q3 24 | $363.6M | $121.6M | ||
| Q2 24 | $381.8M | $124.2M | ||
| Q1 24 | $258.7M | $129.0M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-25.4M | $-1.1M |
| Free Cash FlowOCF − Capex | — | $-1.5M |
| FCF MarginFCF / Revenue | — | -5.0% |
| Capex IntensityCapex / Revenue | — | 1.3% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-6.5M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-25.4M | $-1.1M | ||
| Q3 25 | $-26.6M | $-178.0K | ||
| Q2 25 | $-23.3M | $1.1M | ||
| Q1 25 | $-40.4M | $-5.5M | ||
| Q4 24 | $-18.8M | $2.3M | ||
| Q3 24 | $-25.2M | $-4.8M | ||
| Q2 24 | $-29.1M | $6.2M | ||
| Q1 24 | $-40.7M | $-1.7M |
| Q4 25 | — | $-1.5M | ||
| Q3 25 | — | $-390.0K | ||
| Q2 25 | — | $941.0K | ||
| Q1 25 | — | $-5.5M | ||
| Q4 24 | — | $1.9M | ||
| Q3 24 | — | $-4.9M | ||
| Q2 24 | — | $6.0M | ||
| Q1 24 | — | $-2.0M |
| Q4 25 | — | -5.0% | ||
| Q3 25 | — | -1.4% | ||
| Q2 25 | — | 3.0% | ||
| Q1 25 | — | -18.8% | ||
| Q4 24 | — | 5.7% | ||
| Q3 24 | — | -13.8% | ||
| Q2 24 | — | 16.8% | ||
| Q1 24 | — | -5.7% |
| Q4 25 | — | 1.3% | ||
| Q3 25 | — | 0.7% | ||
| Q2 25 | — | 0.5% | ||
| Q1 25 | — | 0.0% | ||
| Q4 24 | — | 1.2% | ||
| Q3 24 | — | 0.4% | ||
| Q2 24 | — | 0.5% | ||
| Q1 24 | — | 0.9% |
| Q4 25 | — | — | ||
| Q3 25 | — | -0.34× | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | 17.13× | ||
| Q3 24 | — | -12.21× | ||
| Q2 24 | — | 385.25× | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
RYTM
Segment breakdown not available.
SYPR
| Sypris Electronics | $17.7M | 59% |
| Transferred At Point In Time | $12.5M | 41% |
