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Side-by-side financial comparison of RHYTHM PHARMACEUTICALS, INC. (RYTM) and ThredUp Inc. (TDUP). Click either name above to swap in a different company.

ThredUp Inc. is the larger business by last-quarter revenue ($79.7M vs $57.3M, roughly 1.4× RHYTHM PHARMACEUTICALS, INC.). ThredUp Inc. runs the higher net margin — -7.0% vs -83.0%, a 76.0% gap on every dollar of revenue. On growth, RHYTHM PHARMACEUTICALS, INC. posted the faster year-over-year revenue change (36.9% vs 18.5%). Over the past eight quarters, RHYTHM PHARMACEUTICALS, INC.'s revenue compounded faster (48.5% CAGR vs 11.1%).

Rhythm Pharmaceuticals is a biopharmaceutical firm focused on developing and commercializing targeted therapies for rare genetic disorders causing severe unmanageable obesity, including POMC deficiency, LEPR deficiency, and Bardet-Biedl syndrome. It serves patients in North America and Europe who lack effective standard treatments for their chronic life-altering conditions.

ThredUp Inc. is an American company that operates an online resale platform specializing in the sale of second-hand clothing, footwear, and accessories. Founded in 2009 and headquartered in Oakland, California, it has established itself as one of the leading resale fashion marketplaces.

RYTM vs TDUP — Head-to-Head

Bigger by revenue
TDUP
TDUP
1.4× larger
TDUP
$79.7M
$57.3M
RYTM
Growing faster (revenue YoY)
RYTM
RYTM
+18.4% gap
RYTM
36.9%
18.5%
TDUP
Higher net margin
TDUP
TDUP
76.0% more per $
TDUP
-7.0%
-83.0%
RYTM
Faster 2-yr revenue CAGR
RYTM
RYTM
Annualised
RYTM
48.5%
11.1%
TDUP

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
RYTM
RYTM
TDUP
TDUP
Revenue
$57.3M
$79.7M
Net Profit
$-47.5M
$-5.6M
Gross Margin
91.6%
79.6%
Operating Margin
-82.2%
-8.4%
Net Margin
-83.0%
-7.0%
Revenue YoY
36.9%
18.5%
Net Profit YoY
-9.6%
74.3%
EPS (diluted)
$-0.73
$-0.06

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
RYTM
RYTM
TDUP
TDUP
Q4 25
$57.3M
$79.7M
Q3 25
$51.3M
$82.2M
Q2 25
$48.5M
$77.7M
Q1 25
$32.7M
$71.3M
Q4 24
$41.8M
$67.3M
Q3 24
$33.3M
$61.5M
Q2 24
$29.1M
$66.7M
Q1 24
$26.0M
$64.5M
Net Profit
RYTM
RYTM
TDUP
TDUP
Q4 25
$-47.5M
$-5.6M
Q3 25
$-52.9M
$-4.2M
Q2 25
$-46.6M
$-5.2M
Q1 25
$-49.5M
$-5.2M
Q4 24
$-43.3M
$-21.7M
Q3 24
$-43.6M
$-24.8M
Q2 24
$-32.3M
$-14.0M
Q1 24
$-141.4M
$-16.6M
Gross Margin
RYTM
RYTM
TDUP
TDUP
Q4 25
91.6%
79.6%
Q3 25
89.3%
79.4%
Q2 25
88.6%
79.5%
Q1 25
88.8%
79.1%
Q4 24
90.9%
80.4%
Q3 24
88.5%
79.3%
Q2 24
89.9%
78.8%
Q1 24
89.2%
80.1%
Operating Margin
RYTM
RYTM
TDUP
TDUP
Q4 25
-82.2%
-8.4%
Q3 25
-102.6%
-5.3%
Q2 25
-93.4%
-6.8%
Q1 25
-143.7%
-7.6%
Q4 24
-98.6%
-12.1%
Q3 24
-132.0%
-17.0%
Q2 24
-139.2%
-14.4%
Q1 24
-538.7%
-19.2%
Net Margin
RYTM
RYTM
TDUP
TDUP
Q4 25
-83.0%
-7.0%
Q3 25
-103.1%
-5.2%
Q2 25
-96.1%
-6.7%
Q1 25
-151.4%
-7.3%
Q4 24
-103.6%
-32.3%
Q3 24
-131.2%
-40.3%
Q2 24
-110.9%
-20.9%
Q1 24
-544.4%
-25.7%
EPS (diluted)
RYTM
RYTM
TDUP
TDUP
Q4 25
$-0.73
$-0.06
Q3 25
$-0.82
$-0.03
Q2 25
$-0.75
$-0.04
Q1 25
$-0.81
$-0.04
Q4 24
$-0.71
$-0.19
Q3 24
$-0.73
$-0.22
Q2 24
$-0.55
$-0.13
Q1 24
$-2.35
$-0.15

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
RYTM
RYTM
TDUP
TDUP
Cash + ST InvestmentsLiquidity on hand
$388.9M
$38.6M
Total DebtLower is stronger
Stockholders' EquityBook value
$139.1M
$59.2M
Total Assets
$480.2M
$167.2M
Debt / EquityLower = less leverage

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
RYTM
RYTM
TDUP
TDUP
Q4 25
$388.9M
$38.6M
Q3 25
$416.1M
$46.2M
Q2 25
$291.0M
$41.0M
Q1 25
$314.5M
$41.1M
Q4 24
$320.6M
$31.9M
Q3 24
$298.4M
$43.7M
Q2 24
$319.1M
$44.8M
Q1 24
$201.2M
$50.1M
Stockholders' Equity
RYTM
RYTM
TDUP
TDUP
Q4 25
$139.1M
$59.2M
Q3 25
$148.8M
$59.1M
Q2 25
$-11.9M
$60.2M
Q1 25
$18.9M
$56.1M
Q4 24
$21.7M
$56.3M
Q3 24
$11.2M
$69.3M
Q2 24
$39.3M
$86.5M
Q1 24
$61.6M
$93.5M
Total Assets
RYTM
RYTM
TDUP
TDUP
Q4 25
$480.2M
$167.2M
Q3 25
$506.9M
$172.5M
Q2 25
$372.7M
$173.6M
Q1 25
$386.7M
$172.5M
Q4 24
$392.3M
$171.2M
Q3 24
$363.6M
$214.9M
Q2 24
$381.8M
$231.2M
Q1 24
$258.7M
$244.3M

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
RYTM
RYTM
TDUP
TDUP
Operating Cash FlowLast quarter
$-25.4M
$-1.5M
Free Cash FlowOCF − Capex
$-3.2M
FCF MarginFCF / Revenue
-4.0%
Capex IntensityCapex / Revenue
2.2%
Cash ConversionOCF / Net Profit
TTM Free Cash FlowTrailing 4 quarters
$180.0K

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
RYTM
RYTM
TDUP
TDUP
Q4 25
$-25.4M
$-1.5M
Q3 25
$-26.6M
$6.0M
Q2 25
$-23.3M
$344.0K
Q1 25
$-40.4M
$5.7M
Q4 24
$-18.8M
$663.0K
Q3 24
$-25.2M
$3.3M
Q2 24
$-29.1M
$-5.0M
Q1 24
$-40.7M
$1.4M
Free Cash Flow
RYTM
RYTM
TDUP
TDUP
Q4 25
$-3.2M
Q3 25
$2.4M
Q2 25
$-2.9M
Q1 25
$3.9M
Q4 24
$-1.8M
Q3 24
$1.2M
Q2 24
$-5.8M
Q1 24
$267.0K
FCF Margin
RYTM
RYTM
TDUP
TDUP
Q4 25
-4.0%
Q3 25
2.9%
Q2 25
-3.8%
Q1 25
5.5%
Q4 24
-2.7%
Q3 24
2.0%
Q2 24
-8.7%
Q1 24
0.4%
Capex Intensity
RYTM
RYTM
TDUP
TDUP
Q4 25
2.2%
Q3 25
4.4%
Q2 25
4.2%
Q1 25
2.5%
Q4 24
3.7%
Q3 24
3.5%
Q2 24
1.3%
Q1 24
1.7%

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

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