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Side-by-side financial comparison of Schrodinger, Inc. (SDGR) and GeneDx Holdings Corp. (WGS). Click either name above to swap in a different company.
GeneDx Holdings Corp. is the larger business by last-quarter revenue ($121.0M vs $87.2M, roughly 1.4× Schrodinger, Inc.). Schrodinger, Inc. runs the higher net margin — 37.3% vs -14.6%, a 51.9% gap on every dollar of revenue. On growth, GeneDx Holdings Corp. posted the faster year-over-year revenue change (26.5% vs -1.2%). GeneDx Holdings Corp. produced more free cash flow last quarter ($-7.4M vs $-16.1M). Over the past eight quarters, Schrodinger, Inc.'s revenue compounded faster (54.4% CAGR vs 39.2%).
Schrodinger, Inc. is a leading provider of advanced computational chemistry and physics software platforms, along with related consulting services, focused on accelerating drug discovery and novel materials development. Its solutions are adopted by biopharmaceutical companies, chemical manufacturers, academic research institutions and government entities across North America, Europe and Asia Pacific to cut R&D costs and shorten innovation cycles.
GeneDx is a genetic testing company that was founded in 2000 by two scientists from the National Institutes of Health (NIH), Sherri Bale and John Compton. They started the company to provide clinical diagnostic services for patients and families with rare and ultra-rare disorders, for which no such commercial testing was available at the time. The company started in the Technology Development Center, a biotech incubator supported by the state of Maryland and Montgomery County, MD. In 2006, Bi...
SDGR vs WGS — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $87.2M | $121.0M |
| Net Profit | $32.5M | $-17.7M |
| Gross Margin | 65.7% | 69.6% |
| Operating Margin | -19.7% | -11.8% |
| Net Margin | 37.3% | -14.6% |
| Revenue YoY | -1.2% | 26.5% |
| Net Profit YoY | 180.8% | -424.9% |
| EPS (diluted) | $0.45 | $-0.59 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $87.2M | $121.0M | ||
| Q3 25 | $54.3M | $116.7M | ||
| Q2 25 | $54.8M | $102.7M | ||
| Q1 25 | $59.6M | $87.1M | ||
| Q4 24 | $88.3M | $95.6M | ||
| Q3 24 | $35.3M | $76.9M | ||
| Q2 24 | $47.3M | $70.5M | ||
| Q1 24 | $36.6M | $62.4M |
| Q4 25 | $32.5M | $-17.7M | ||
| Q3 25 | $-32.8M | $-7.6M | ||
| Q2 25 | $-43.2M | $10.8M | ||
| Q1 25 | $-59.8M | $-6.5M | ||
| Q4 24 | $-40.2M | $5.4M | ||
| Q3 24 | $-38.1M | $-8.3M | ||
| Q2 24 | $-54.0M | $-29.2M | ||
| Q1 24 | $-54.7M | $-20.2M |
| Q4 25 | 65.7% | 69.6% | ||
| Q3 25 | 51.6% | 72.4% | ||
| Q2 25 | 47.8% | 69.0% | ||
| Q1 25 | 52.3% | 67.1% | ||
| Q4 24 | 72.6% | 69.2% | ||
| Q3 24 | 50.2% | 62.2% | ||
| Q2 24 | 66.2% | 60.9% | ||
| Q1 24 | 51.6% | 59.9% |
| Q4 25 | -19.7% | -11.8% | ||
| Q3 25 | -84.6% | -2.8% | ||
| Q2 25 | -96.6% | 8.7% | ||
| Q1 25 | -85.5% | -5.2% | ||
| Q4 24 | -23.5% | 9.2% | ||
| Q3 24 | -193.9% | -10.1% | ||
| Q2 24 | -111.4% | -15.0% | ||
| Q1 24 | -184.3% | -21.9% |
| Q4 25 | 37.3% | -14.6% | ||
| Q3 25 | -60.4% | -6.5% | ||
| Q2 25 | -78.8% | 10.5% | ||
| Q1 25 | -100.4% | -7.5% | ||
| Q4 24 | -45.5% | 5.7% | ||
| Q3 24 | -108.1% | -10.8% | ||
| Q2 24 | -114.2% | -41.4% | ||
| Q1 24 | -149.5% | -32.4% |
| Q4 25 | $0.45 | $-0.59 | ||
| Q3 25 | $-0.45 | $-0.27 | ||
| Q2 25 | $-0.59 | $0.36 | ||
| Q1 25 | $-0.82 | $-0.23 | ||
| Q4 24 | $-0.55 | $0.25 | ||
| Q3 24 | $-0.52 | $-0.31 | ||
| Q2 24 | $-0.74 | $-1.10 | ||
| Q1 24 | $-0.76 | $-0.78 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $395.5M | $171.3M |
| Total DebtLower is stronger | — | $54.5M |
| Stockholders' EquityBook value | $364.1M | $308.2M |
| Total Assets | $726.2M | $523.7M |
| Debt / EquityLower = less leverage | — | 0.18× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $395.5M | $171.3M | ||
| Q3 25 | $391.2M | $155.1M | ||
| Q2 25 | $450.2M | $134.6M | ||
| Q1 25 | $500.3M | $159.2M | ||
| Q4 24 | $352.1M | $141.2M | ||
| Q3 24 | $388.7M | $116.5M | ||
| Q2 24 | $377.3M | $106.9M | ||
| Q1 24 | $431.1M | $112.9M |
| Q4 25 | — | $54.5M | ||
| Q3 25 | — | $54.8M | ||
| Q2 25 | — | $55.1M | ||
| Q1 25 | — | $55.5M | ||
| Q4 24 | — | $55.8M | ||
| Q3 24 | — | $56.1M | ||
| Q2 24 | — | $56.3M | ||
| Q1 24 | — | $56.3M |
| Q4 25 | $364.1M | $308.2M | ||
| Q3 25 | $321.4M | $292.3M | ||
| Q2 25 | $342.9M | $277.1M | ||
| Q1 25 | $373.5M | $257.4M | ||
| Q4 24 | $421.4M | $245.2M | ||
| Q3 24 | $449.4M | $204.5M | ||
| Q2 24 | $474.0M | $194.0M | ||
| Q1 24 | $513.7M | $207.2M |
| Q4 25 | $726.2M | $523.7M | ||
| Q3 25 | $653.7M | $493.9M | ||
| Q2 25 | $688.2M | $463.9M | ||
| Q1 25 | $743.0M | $446.4M | ||
| Q4 24 | $823.2M | $419.4M | ||
| Q3 24 | $669.3M | $408.8M | ||
| Q2 24 | $688.4M | $389.1M | ||
| Q1 24 | $737.8M | $394.5M |
| Q4 25 | — | 0.18× | ||
| Q3 25 | — | 0.19× | ||
| Q2 25 | — | 0.20× | ||
| Q1 25 | — | 0.22× | ||
| Q4 24 | — | 0.23× | ||
| Q3 24 | — | 0.27× | ||
| Q2 24 | — | 0.29× | ||
| Q1 24 | — | 0.27× |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-16.1M | $-3.1M |
| Free Cash FlowOCF − Capex | $-16.1M | $-7.4M |
| FCF MarginFCF / Revenue | -18.5% | -6.1% |
| Capex IntensityCapex / Revenue | 0.0% | 3.6% |
| Cash ConversionOCF / Net Profit | -0.50× | — |
| TTM Free Cash FlowTrailing 4 quarters | $12.5M | $14.3M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-16.1M | $-3.1M | ||
| Q3 25 | $-61.9M | $15.8M | ||
| Q2 25 | $-52.2M | $10.4M | ||
| Q1 25 | $144.1M | $10.2M | ||
| Q4 24 | $-31.1M | $-3.2M | ||
| Q3 24 | $-33.3M | $-4.4M | ||
| Q2 24 | $-53.7M | $-4.5M | ||
| Q1 24 | $-39.3M | $-16.4M |
| Q4 25 | $-16.1M | $-7.4M | ||
| Q3 25 | $-62.4M | $9.6M | ||
| Q2 25 | $-52.5M | $8.1M | ||
| Q1 25 | $143.5M | $4.1M | ||
| Q4 24 | $-32.0M | $-6.2M | ||
| Q3 24 | $-34.6M | $-5.0M | ||
| Q2 24 | $-54.7M | $-5.9M | ||
| Q1 24 | $-43.4M | $-16.9M |
| Q4 25 | -18.5% | -6.1% | ||
| Q3 25 | -114.8% | 8.2% | ||
| Q2 25 | -95.9% | 7.8% | ||
| Q1 25 | 240.9% | 4.7% | ||
| Q4 24 | -36.2% | -6.5% | ||
| Q3 24 | -98.0% | -6.6% | ||
| Q2 24 | -115.6% | -8.3% | ||
| Q1 24 | -118.5% | -27.0% |
| Q4 25 | 0.0% | 3.6% | ||
| Q3 25 | 0.9% | 5.3% | ||
| Q2 25 | 0.6% | 2.3% | ||
| Q1 25 | 1.0% | 7.0% | ||
| Q4 24 | 1.0% | 3.2% | ||
| Q3 24 | 3.8% | 0.8% | ||
| Q2 24 | 2.1% | 1.9% | ||
| Q1 24 | 11.2% | 0.7% |
| Q4 25 | -0.50× | — | ||
| Q3 25 | — | — | ||
| Q2 25 | — | 0.96× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | -0.59× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
SDGR
| On Premise Software | $44.4M | 51% |
| Drug Discovery Services | $17.6M | 20% |
| Hosted Software | $11.5M | 13% |
| Maintenance | $6.9M | 8% |
| Professional Services | $3.8M | 4% |
| July2024Agreement With Bill Melinda Gates Foundation | $2.7M | 3% |
WGS
| Diagnostic Test Third Party Insurance | $101.1M | 84% |
| Diagnostic Test Institutional Customers | $15.5M | 13% |
| Other | $3.4M | 3% |
