vs
Side-by-side financial comparison of Septerna, Inc. (SEPN) and Simulations Plus, Inc. (SLP). Click either name above to swap in a different company.
Septerna, Inc. is the larger business by last-quarter revenue ($24.1M vs $18.4M, roughly 1.3× Simulations Plus, Inc.). Simulations Plus, Inc. runs the higher net margin — 3.7% vs -44.5%, a 48.2% gap on every dollar of revenue.
Septerna, Inc. is a clinical-stage biotechnology company focused on developing novel therapies targeting G protein-coupled receptors (GPCRs), a large family of cell surface proteins involved in many disease pathways. Its pipeline includes candidates for inflammatory, metabolic, and central nervous system disorders, addressing global unmet medical needs.
Simulations Plus, Inc. develops absorption, distribution, metabolism, excretion, and toxicity (ADMET) modeling and simulation software for the pharmaceutical and biotechnology, industrial chemicals, cosmetics, food ingredients, and herbicide industries. In September 2014, the company acquired Cognigen Corporation, a provider of clinical trial data analysis and consulting services.
SEPN vs SLP — Head-to-Head
Income Statement — Q4 FY2025 vs Q1 FY2026
| Metric | | |
|---|---|---|
| Revenue | $24.1M | $18.4M |
| Net Profit | $-10.7M | $676.0K |
| Gross Margin | — | 59.1% |
| Operating Margin | -66.4% | 3.9% |
| Net Margin | -44.5% | 3.7% |
| Revenue YoY | — | -2.7% |
| Net Profit YoY | — | 228.2% |
| EPS (diluted) | $-0.23 | $0.03 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $24.1M | $18.4M | ||
| Q3 25 | $21.5M | $17.5M | ||
| Q2 25 | — | $20.4M | ||
| Q1 25 | — | $22.4M | ||
| Q4 24 | — | $18.9M | ||
| Q3 24 | — | $18.7M | ||
| Q2 24 | — | $18.5M | ||
| Q1 24 | — | $18.3M |
| Q4 25 | $-10.7M | $676.0K | ||
| Q3 25 | $8.2M | $-681.0K | ||
| Q2 25 | — | $-67.3M | ||
| Q1 25 | — | $3.1M | ||
| Q4 24 | — | $206.0K | ||
| Q3 24 | — | $843.0K | ||
| Q2 24 | — | $3.1M | ||
| Q1 24 | — | $4.0M |
| Q4 25 | — | 59.1% | ||
| Q3 25 | — | 56.4% | ||
| Q2 25 | — | 64.0% | ||
| Q1 25 | — | 58.5% | ||
| Q4 24 | — | 54.0% | ||
| Q3 24 | — | 36.6% | ||
| Q2 24 | — | 71.5% | ||
| Q1 24 | — | 72.2% |
| Q4 25 | -66.4% | 3.9% | ||
| Q3 25 | 12.2% | 3.8% | ||
| Q2 25 | — | -364.5% | ||
| Q1 25 | — | 12.1% | ||
| Q4 24 | — | 0.7% | ||
| Q3 24 | — | -6.2% | ||
| Q2 24 | — | 10.1% | ||
| Q1 24 | — | 24.3% |
| Q4 25 | -44.5% | 3.7% | ||
| Q3 25 | 38.0% | -3.9% | ||
| Q2 25 | — | -330.6% | ||
| Q1 25 | — | 13.7% | ||
| Q4 24 | — | 1.1% | ||
| Q3 24 | — | 4.5% | ||
| Q2 24 | — | 16.9% | ||
| Q1 24 | — | 22.0% |
| Q4 25 | $-0.23 | $0.03 | ||
| Q3 25 | $0.18 | $-0.03 | ||
| Q2 25 | — | $-3.35 | ||
| Q1 25 | — | $0.15 | ||
| Q4 24 | — | $0.01 | ||
| Q3 24 | — | $0.04 | ||
| Q2 24 | — | $0.15 | ||
| Q1 24 | — | $0.20 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $391.1M | $35.7M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $381.9M | $127.1M |
| Total Assets | $596.2M | $137.8M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $391.1M | $35.7M | ||
| Q3 25 | $474.3M | $32.4M | ||
| Q2 25 | — | $28.4M | ||
| Q1 25 | — | $21.4M | ||
| Q4 24 | — | $18.2M | ||
| Q3 24 | — | $20.3M | ||
| Q2 24 | — | $119.0M | ||
| Q1 24 | — | $108.5M |
| Q4 25 | $381.9M | $127.1M | ||
| Q3 25 | $388.7M | $124.8M | ||
| Q2 25 | — | $123.8M | ||
| Q1 25 | — | $189.5M | ||
| Q4 24 | — | $184.7M | ||
| Q3 24 | — | $182.4M | ||
| Q2 24 | — | $180.9M | ||
| Q1 24 | — | $177.0M |
| Q4 25 | $596.2M | $137.8M | ||
| Q3 25 | $606.7M | $131.9M | ||
| Q2 25 | — | $134.4M | ||
| Q1 25 | — | $201.4M | ||
| Q4 24 | — | $196.9M | ||
| Q3 24 | — | $196.6M | ||
| Q2 24 | — | $192.7M | ||
| Q1 24 | — | $194.0M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-15.0M | $4.2M |
| Free Cash FlowOCF − Capex | $-15.1M | — |
| FCF MarginFCF / Revenue | -62.4% | — |
| Capex IntensityCapex / Revenue | 0.3% | 0.0% |
| Cash ConversionOCF / Net Profit | — | 6.26× |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-15.0M | $4.2M | ||
| Q3 25 | $168.8M | $5.6M | ||
| Q2 25 | — | $8.1M | ||
| Q1 25 | — | $5.7M | ||
| Q4 24 | — | $-1.3M | ||
| Q3 24 | — | $1.7M | ||
| Q2 24 | — | $5.7M | ||
| Q1 24 | — | $5.8M |
| Q4 25 | $-15.1M | — | ||
| Q3 25 | $168.8M | $5.3M | ||
| Q2 25 | — | $7.8M | ||
| Q1 25 | — | $5.6M | ||
| Q4 24 | — | $-1.4M | ||
| Q3 24 | — | $1.6M | ||
| Q2 24 | — | $5.6M | ||
| Q1 24 | — | $5.4M |
| Q4 25 | -62.4% | — | ||
| Q3 25 | 785.3% | 30.5% | ||
| Q2 25 | — | 38.5% | ||
| Q1 25 | — | 25.0% | ||
| Q4 24 | — | -7.2% | ||
| Q3 24 | — | 8.8% | ||
| Q2 24 | — | 30.0% | ||
| Q1 24 | — | 29.4% |
| Q4 25 | 0.3% | 0.0% | ||
| Q3 25 | 0.1% | 1.5% | ||
| Q2 25 | — | 1.5% | ||
| Q1 25 | — | 0.3% | ||
| Q4 24 | — | 0.5% | ||
| Q3 24 | — | 0.1% | ||
| Q2 24 | — | 0.6% | ||
| Q1 24 | — | 2.4% |
| Q4 25 | — | 6.26× | ||
| Q3 25 | 20.65× | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | 1.84× | ||
| Q4 24 | — | -6.18× | ||
| Q3 24 | — | 1.97× | ||
| Q2 24 | — | 1.81× | ||
| Q1 24 | — | 1.44× |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
SEPN
Segment breakdown not available.
SLP
| Services Segment | $9.5M | 52% |
| Development | $7.2M | 39% |
| Discovery | $1.3M | 7% |
