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Side-by-side financial comparison of Simulations Plus, Inc. (SLP) and Xilio Therapeutics, Inc. (XLO). Click either name above to swap in a different company.
Simulations Plus, Inc. is the larger business by last-quarter revenue ($18.4M vs $13.7M, roughly 1.3× Xilio Therapeutics, Inc.). Xilio Therapeutics, Inc. runs the higher net margin — 75.7% vs 3.7%, a 72.0% gap on every dollar of revenue.
Simulations Plus, Inc. develops absorption, distribution, metabolism, excretion, and toxicity (ADMET) modeling and simulation software for the pharmaceutical and biotechnology, industrial chemicals, cosmetics, food ingredients, and herbicide industries. In September 2014, the company acquired Cognigen Corporation, a provider of clinical trial data analysis and consulting services.
Xilio Therapeutics is a clinical-stage biotechnology company dedicated to developing novel tumor-selective immunotherapies for cancer treatment. Its product pipeline features candidates engineered to trigger anti-tumor immune responses specifically inside tumor microenvironments, reducing systemic toxicities, and it primarily targets oncology patient populations in North America and other global markets.
SLP vs XLO — Head-to-Head
Income Statement — Q1 FY2026 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $18.4M | $13.7M |
| Net Profit | $676.0K | $10.4M |
| Gross Margin | 59.1% | — |
| Operating Margin | 3.9% | -86.5% |
| Net Margin | 3.7% | 75.7% |
| Revenue YoY | -2.7% | — |
| Net Profit YoY | 228.2% | 179.1% |
| EPS (diluted) | $0.03 | $-3.74 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $18.4M | $13.7M | ||
| Q3 25 | $17.5M | $19.1M | ||
| Q2 25 | $20.4M | $8.1M | ||
| Q1 25 | $22.4M | $2.9M | ||
| Q4 24 | $18.9M | — | ||
| Q3 24 | $18.7M | — | ||
| Q2 24 | $18.5M | — | ||
| Q1 24 | $18.3M | — |
| Q4 25 | $676.0K | $10.4M | ||
| Q3 25 | $-681.0K | $-16.3M | ||
| Q2 25 | $-67.3M | $-15.8M | ||
| Q1 25 | $3.1M | $-13.3M | ||
| Q4 24 | $206.0K | — | ||
| Q3 24 | $843.0K | — | ||
| Q2 24 | $3.1M | — | ||
| Q1 24 | $4.0M | — |
| Q4 25 | 59.1% | — | ||
| Q3 25 | 56.4% | — | ||
| Q2 25 | 64.0% | — | ||
| Q1 25 | 58.5% | — | ||
| Q4 24 | 54.0% | — | ||
| Q3 24 | 36.6% | — | ||
| Q2 24 | 71.5% | — | ||
| Q1 24 | 72.2% | — |
| Q4 25 | 3.9% | -86.5% | ||
| Q3 25 | 3.8% | -10.1% | ||
| Q2 25 | -364.5% | -177.7% | ||
| Q1 25 | 12.1% | -472.7% | ||
| Q4 24 | 0.7% | — | ||
| Q3 24 | -6.2% | — | ||
| Q2 24 | 10.1% | — | ||
| Q1 24 | 24.3% | — |
| Q4 25 | 3.7% | 75.7% | ||
| Q3 25 | -3.9% | -85.4% | ||
| Q2 25 | -330.6% | -196.0% | ||
| Q1 25 | 13.7% | -452.7% | ||
| Q4 24 | 1.1% | — | ||
| Q3 24 | 4.5% | — | ||
| Q2 24 | 16.9% | — | ||
| Q1 24 | 22.0% | — |
| Q4 25 | $0.03 | $-3.74 | ||
| Q3 25 | $-0.03 | $-0.11 | ||
| Q2 25 | $-3.35 | $-0.16 | ||
| Q1 25 | $0.15 | $-0.18 | ||
| Q4 24 | $0.01 | — | ||
| Q3 24 | $0.04 | — | ||
| Q2 24 | $0.15 | — | ||
| Q1 24 | $0.20 | — |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $35.7M | $137.5M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $127.1M | $35.3M |
| Total Assets | $137.8M | $154.7M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $35.7M | $137.5M | ||
| Q3 25 | $32.4M | $103.8M | ||
| Q2 25 | $28.4M | $121.6M | ||
| Q1 25 | $21.4M | $89.1M | ||
| Q4 24 | $18.2M | — | ||
| Q3 24 | $20.3M | — | ||
| Q2 24 | $119.0M | — | ||
| Q1 24 | $108.5M | — |
| Q4 25 | $127.1M | $35.3M | ||
| Q3 25 | $124.8M | $-8.1M | ||
| Q2 25 | $123.8M | $7.1M | ||
| Q1 25 | $189.5M | $10.7M | ||
| Q4 24 | $184.7M | — | ||
| Q3 24 | $182.4M | — | ||
| Q2 24 | $180.9M | — | ||
| Q1 24 | $177.0M | — |
| Q4 25 | $137.8M | $154.7M | ||
| Q3 25 | $131.9M | $133.7M | ||
| Q2 25 | $134.4M | $133.8M | ||
| Q1 25 | $201.4M | $103.7M | ||
| Q4 24 | $196.9M | — | ||
| Q3 24 | $196.6M | — | ||
| Q2 24 | $192.7M | — | ||
| Q1 24 | $194.0M | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $4.2M | $-2.0M |
| Free Cash FlowOCF − Capex | — | $-2.1M |
| FCF MarginFCF / Revenue | — | -15.3% |
| Capex IntensityCapex / Revenue | 0.0% | 0.7% |
| Cash ConversionOCF / Net Profit | 6.26× | -0.19× |
| TTM Free Cash FlowTrailing 4 quarters | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $4.2M | $-2.0M | ||
| Q3 25 | $5.6M | $-17.5M | ||
| Q2 25 | $8.1M | $-14.5M | ||
| Q1 25 | $5.7M | $29.0M | ||
| Q4 24 | $-1.3M | — | ||
| Q3 24 | $1.7M | — | ||
| Q2 24 | $5.7M | — | ||
| Q1 24 | $5.8M | — |
| Q4 25 | — | $-2.1M | ||
| Q3 25 | $5.3M | — | ||
| Q2 25 | $7.8M | $-14.9M | ||
| Q1 25 | $5.6M | $29.0M | ||
| Q4 24 | $-1.4M | — | ||
| Q3 24 | $1.6M | — | ||
| Q2 24 | $5.6M | — | ||
| Q1 24 | $5.4M | — |
| Q4 25 | — | -15.3% | ||
| Q3 25 | 30.5% | — | ||
| Q2 25 | 38.5% | -184.0% | ||
| Q1 25 | 25.0% | 988.3% | ||
| Q4 24 | -7.2% | — | ||
| Q3 24 | 8.8% | — | ||
| Q2 24 | 30.0% | — | ||
| Q1 24 | 29.4% | — |
| Q4 25 | 0.0% | 0.7% | ||
| Q3 25 | 1.5% | 0.0% | ||
| Q2 25 | 1.5% | 5.0% | ||
| Q1 25 | 0.3% | 0.8% | ||
| Q4 24 | 0.5% | — | ||
| Q3 24 | 0.1% | — | ||
| Q2 24 | 0.6% | — | ||
| Q1 24 | 2.4% | — |
| Q4 25 | 6.26× | -0.19× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | 1.84× | — | ||
| Q4 24 | -6.18× | — | ||
| Q3 24 | 1.97× | — | ||
| Q2 24 | 1.81× | — | ||
| Q1 24 | 1.44× | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
SLP
| Services Segment | $9.5M | 52% |
| Development | $7.2M | 39% |
| Discovery | $1.3M | 7% |
XLO
Segment breakdown not available.
