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Side-by-side financial comparison of STEM, INC. (STEM) and Zymeworks Inc. (ZYME). Click either name above to swap in a different company.
STEM, INC. is the larger business by last-quarter revenue ($47.1M vs $27.6M, roughly 1.7× Zymeworks Inc.). STEM, INC. runs the higher net margin — -33.9% vs -71.0%, a 37.1% gap on every dollar of revenue. On growth, Zymeworks Inc. posted the faster year-over-year revenue change (72.6% vs -15.6%).
StemCells, Inc. is a public biopharmaceutical company headquartered in Newark, California, that is developing purified human neural stem cells (HuCNS-SCs) in the hopes of treating central nervous system disorders and paralysis. StemCells' HuCNS-SCs have the ability to differentiate into the three main types of cells found in the central nervous system: neurons, astrocytes and oligodendrocytes.
Zymeworks Inc. is a publicly held biotechnology company based in Vancouver, British Columbia, that develops protein therapeutics for the treatment of cancer as well as for autoimmune and inflammatory diseases. The products are based upon the company's molecular modeling software for optimizing protein structure. In 2014, Zymeworks raised $44 million across various funding rounds according to PitchBook, placing it among the top 10 HealthTech businesses in the world to raise the most capital th...
STEM vs ZYME — Head-to-Head
Income Statement — Q4 FY2025 vs Q3 FY2025
| Metric | | |
|---|---|---|
| Revenue | $47.1M | $27.6M |
| Net Profit | $-16.0M | $-19.6M |
| Gross Margin | 48.9% | — |
| Operating Margin | -17.7% | -80.1% |
| Net Margin | -33.9% | -71.0% |
| Revenue YoY | -15.6% | 72.6% |
| Net Profit YoY | 68.8% | 34.3% |
| EPS (diluted) | $-4.40 | $-0.26 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $47.1M | — | ||
| Q3 25 | $38.2M | $27.6M | ||
| Q2 25 | $38.4M | $48.7M | ||
| Q1 25 | $32.5M | $27.1M | ||
| Q4 24 | $55.8M | $31.0M | ||
| Q3 24 | $29.3M | $16.0M | ||
| Q2 24 | $34.0M | $19.2M | ||
| Q1 24 | $25.5M | $10.0M |
| Q4 25 | $-16.0M | — | ||
| Q3 25 | $-23.8M | $-19.6M | ||
| Q2 25 | $202.5M | $2.3M | ||
| Q1 25 | $-25.0M | $-22.6M | ||
| Q4 24 | $-51.1M | $-23.5M | ||
| Q3 24 | $-148.3M | $-29.9M | ||
| Q2 24 | $-582.3M | $-37.7M | ||
| Q1 24 | $-72.3M | $-31.7M |
| Q4 25 | 48.9% | — | ||
| Q3 25 | 35.5% | — | ||
| Q2 25 | 33.4% | — | ||
| Q1 25 | 32.4% | — | ||
| Q4 24 | -4.4% | — | ||
| Q3 24 | 21.2% | — | ||
| Q2 24 | 27.6% | — | ||
| Q1 24 | -95.0% | — |
| Q4 25 | -17.7% | — | ||
| Q3 25 | -33.6% | -80.1% | ||
| Q2 25 | -34.8% | -1.4% | ||
| Q1 25 | -65.0% | -94.5% | ||
| Q4 24 | -84.4% | -71.6% | ||
| Q3 24 | -493.2% | -213.8% | ||
| Q2 24 | -1705.5% | -222.9% | ||
| Q1 24 | -267.0% | -376.9% |
| Q4 25 | -33.9% | — | ||
| Q3 25 | -62.2% | -71.0% | ||
| Q2 25 | 527.8% | 4.8% | ||
| Q1 25 | -76.9% | -83.5% | ||
| Q4 24 | -91.6% | -75.8% | ||
| Q3 24 | -506.3% | -186.6% | ||
| Q2 24 | -1712.6% | -195.8% | ||
| Q1 24 | -283.9% | -315.6% |
| Q4 25 | $-4.40 | — | ||
| Q3 25 | $-2.84 | $-0.26 | ||
| Q2 25 | $-1.79 | $0.03 | ||
| Q1 25 | $-0.15 | $-0.30 | ||
| Q4 24 | $-15.29 | $-0.32 | ||
| Q3 24 | $-18.24 | $-0.39 | ||
| Q2 24 | $-71.81 | $-0.49 | ||
| Q1 24 | $-0.46 | $-0.42 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $48.9M | $64.8M |
| Total DebtLower is stronger | — | — |
| Stockholders' EquityBook value | $-249.4M | $320.1M |
| Total Assets | $308.9M | $397.3M |
| Debt / EquityLower = less leverage | — | — |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $48.9M | — | ||
| Q3 25 | $43.1M | $64.8M | ||
| Q2 25 | $40.8M | $98.3M | ||
| Q1 25 | $58.6M | $76.2M | ||
| Q4 24 | $56.3M | $66.1M | ||
| Q3 24 | $75.4M | $122.4M | ||
| Q2 24 | $89.6M | $71.0M | ||
| Q1 24 | $112.8M | $114.8M |
| Q4 25 | $-249.4M | — | ||
| Q3 25 | $-235.7M | $320.1M | ||
| Q2 25 | $-214.1M | $334.5M | ||
| Q1 25 | $-417.5M | $325.0M | ||
| Q4 24 | $-398.4M | $338.8M | ||
| Q3 24 | $-344.1M | $367.0M | ||
| Q2 24 | $-203.2M | $406.2M | ||
| Q1 24 | $371.6M | $438.0M |
| Q4 25 | $308.9M | — | ||
| Q3 25 | $362.6M | $397.3M | ||
| Q2 25 | $379.2M | $408.4M | ||
| Q1 25 | $405.1M | $425.5M | ||
| Q4 24 | $437.4M | $463.1M | ||
| Q3 24 | $537.8M | $487.2M | ||
| Q2 24 | $691.5M | $515.6M | ||
| Q1 24 | $1.3B | $553.8M |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $8.2M | $-31.4M |
| Free Cash FlowOCF − Capex | — | $-31.8M |
| FCF MarginFCF / Revenue | — | -115.2% |
| Capex IntensityCapex / Revenue | — | 1.5% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | — | $-65.5M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $8.2M | — | ||
| Q3 25 | $11.4M | $-31.4M | ||
| Q2 25 | $-21.3M | $12.1M | ||
| Q1 25 | $8.5M | $-3.4M | ||
| Q4 24 | $-14.7M | $-41.5M | ||
| Q3 24 | $-9.4M | $-5.9M | ||
| Q2 24 | $-11.9M | $-25.0M | ||
| Q1 24 | $-621.0K | $-37.7M |
| Q4 25 | — | — | ||
| Q3 25 | — | $-31.8M | ||
| Q2 25 | — | $11.6M | ||
| Q1 25 | — | $-3.4M | ||
| Q4 24 | — | $-41.8M | ||
| Q3 24 | — | $-6.8M | ||
| Q2 24 | — | $-25.6M | ||
| Q1 24 | — | $-37.9M |
| Q4 25 | — | — | ||
| Q3 25 | — | -115.2% | ||
| Q2 25 | — | 23.7% | ||
| Q1 25 | — | -12.6% | ||
| Q4 24 | — | -134.8% | ||
| Q3 24 | — | -42.4% | ||
| Q2 24 | — | -133.0% | ||
| Q1 24 | — | -377.5% |
| Q4 25 | — | — | ||
| Q3 25 | — | 1.5% | ||
| Q2 25 | — | 1.1% | ||
| Q1 25 | — | 0.1% | ||
| Q4 24 | — | 1.0% | ||
| Q3 24 | — | 5.6% | ||
| Q2 24 | — | 3.1% | ||
| Q1 24 | — | 1.8% |
| Q4 25 | — | — | ||
| Q3 25 | — | — | ||
| Q2 25 | -0.11× | 5.21× | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
