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Side-by-side financial comparison of Tonix Pharmaceuticals Holding Corp. (TNXP) and 22nd Century Group, Inc. (XXII). Click either name above to swap in a different company.
Tonix Pharmaceuticals Holding Corp. is the larger business by last-quarter revenue ($5.4M vs $3.5M, roughly 1.5× 22nd Century Group, Inc.). 22nd Century Group, Inc. runs the higher net margin — -79.4% vs -870.3%, a 790.9% gap on every dollar of revenue. On growth, Tonix Pharmaceuticals Holding Corp. posted the faster year-over-year revenue change (108.8% vs -12.0%). 22nd Century Group, Inc. produced more free cash flow last quarter ($2.7M vs $-41.5M). Over the past eight quarters, Tonix Pharmaceuticals Holding Corp.'s revenue compounded faster (47.4% CAGR vs -26.1%).
Tonix Pharmaceuticals is a pharmaceutical company based in Chatham, New Jersey that focuses on repurposed drugs for central nervous system conditions and as of 2020 was also pursuing a vaccine for COVID-19 and a biodefense project.
22nd Century Media was an American media company based in the suburbs of Chicago. The company was founded in 2005 and at one time published 14 weekly community newspapers. The publications had roughly 160,000 subscribers.
TNXP vs XXII — Head-to-Head
Income Statement — Q4 FY2025 vs Q4 FY2025
| Metric | | |
|---|---|---|
| Revenue | $5.4M | $3.5M |
| Net Profit | $-46.9M | $-2.8M |
| Gross Margin | 80.4% | — |
| Operating Margin | -895.8% | -79.2% |
| Net Margin | -870.3% | -79.4% |
| Revenue YoY | 108.8% | -12.0% |
| Net Profit YoY | -112.2% | 38.4% |
| EPS (diluted) | $-4.28 | $-36.48 |
Green = leading value per metric. Periods may differ when fiscal calendars don't align.
8-Quarter Revenue & Profit Trend
Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.
| Q4 25 | $5.4M | $3.5M | ||
| Q3 25 | $3.3M | $4.0M | ||
| Q2 25 | $2.0M | $4.1M | ||
| Q1 25 | $2.4M | $6.0M | ||
| Q4 24 | $2.6M | $4.0M | ||
| Q3 24 | $2.8M | $5.9M | ||
| Q2 24 | $2.2M | $7.9M | ||
| Q1 24 | $2.5M | $6.5M |
| Q4 25 | $-46.9M | $-2.8M | ||
| Q3 25 | $-32.0M | $5.5M | ||
| Q2 25 | $-28.3M | $-3.4M | ||
| Q1 25 | $-16.8M | $-4.3M | ||
| Q4 24 | $-22.1M | $-4.6M | ||
| Q3 24 | $-14.2M | $-3.8M | ||
| Q2 24 | $-78.8M | $-1.1M | ||
| Q1 24 | $-14.9M | $-5.7M |
| Q4 25 | 80.4% | — | ||
| Q3 25 | 58.4% | 36.3% | ||
| Q2 25 | -63.8% | 29.9% | ||
| Q1 25 | 61.2% | — | ||
| Q4 24 | 54.2% | — | ||
| Q3 24 | 44.9% | 47.8% | ||
| Q2 24 | -52.5% | 51.3% | ||
| Q1 24 | 33.1% | — |
| Q4 25 | -895.8% | -79.2% | ||
| Q3 25 | -1005.1% | -80.1% | ||
| Q2 25 | -1416.2% | -73.0% | ||
| Q1 25 | -660.9% | -43.1% | ||
| Q4 24 | -870.6% | -101.8% | ||
| Q3 24 | -551.2% | -56.8% | ||
| Q2 24 | -3501.6% | -25.8% | ||
| Q1 24 | -860.2% | -68.5% |
| Q4 25 | -870.3% | -79.4% | ||
| Q3 25 | -972.9% | 136.8% | ||
| Q2 25 | -1415.0% | -83.4% | ||
| Q1 25 | -692.8% | -72.7% | ||
| Q4 24 | -856.2% | -113.3% | ||
| Q3 24 | -503.6% | -63.2% | ||
| Q2 24 | -3567.8% | -14.0% | ||
| Q1 24 | -601.9% | -88.7% |
| Q4 25 | $-4.28 | $-36.48 | ||
| Q3 25 | $-3.59 | $-0.28 | ||
| Q2 25 | $-3.86 | $-13.61 | ||
| Q1 25 | $-2.84 | $-2.50 | ||
| Q4 24 | $2302.65 | $-42962.00 | ||
| Q3 24 | $-22.68 | $-1760.26 | ||
| Q2 24 | $-1920.85 | $-593.72 | ||
| Q1 24 | $-535.72 | $-395.07 |
Balance Sheet & Financial Strength
Snapshot of each company's liquidity, leverage and book value from the latest quarter.
| Metric | | |
|---|---|---|
| Cash + ST InvestmentsLiquidity on hand | $207.6M | $7.1M |
| Total DebtLower is stronger | — | $708.0K |
| Stockholders' EquityBook value | $245.2M | $15.8M |
| Total Assets | $277.2M | $27.0M |
| Debt / EquityLower = less leverage | — | 0.04× |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $207.6M | $7.1M | ||
| Q3 25 | $190.1M | $4.8M | ||
| Q2 25 | $125.3M | $3.1M | ||
| Q1 25 | $131.7M | $1.1M | ||
| Q4 24 | $98.8M | $4.4M | ||
| Q3 24 | $28.2M | $5.3M | ||
| Q2 24 | $4.2M | $1.3M | ||
| Q1 24 | $7.0M | $1.5M |
| Q4 25 | — | $708.0K | ||
| Q3 25 | — | — | ||
| Q2 25 | — | $3.2M | ||
| Q1 25 | — | $3.9M | ||
| Q4 24 | $8.7M | $6.7M | ||
| Q3 24 | $9.4M | $7.0M | ||
| Q2 24 | $10.1M | $7.5M | ||
| Q1 24 | $10.8M | $14.7M |
| Q4 25 | $245.2M | $15.8M | ||
| Q3 25 | $231.1M | $18.4M | ||
| Q2 25 | $168.0M | $5.6M | ||
| Q1 25 | $180.4M | $3.6M | ||
| Q4 24 | $139.6M | $4.0M | ||
| Q3 24 | $74.2M | $3.5M | ||
| Q2 24 | $42.1M | $-955.0K | ||
| Q1 24 | $108.1M | $-11.6M |
| Q4 25 | $277.2M | $27.0M | ||
| Q3 25 | $252.4M | $32.4M | ||
| Q2 25 | $187.4M | $22.4M | ||
| Q1 25 | $192.9M | $21.5M | ||
| Q4 24 | $162.9M | $21.7M | ||
| Q3 24 | $95.0M | $26.2M | ||
| Q2 24 | $70.3M | $24.1M | ||
| Q1 24 | $135.3M | $24.6M |
| Q4 25 | — | 0.04× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | 0.57× | ||
| Q1 25 | — | 1.08× | ||
| Q4 24 | 0.06× | 1.66× | ||
| Q3 24 | 0.13× | 2.02× | ||
| Q2 24 | 0.24× | — | ||
| Q1 24 | 0.10× | — |
Cash Flow & Capital Efficiency
How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.
| Metric | | |
|---|---|---|
| Operating Cash FlowLast quarter | $-39.6M | $2.7M |
| Free Cash FlowOCF − Capex | $-41.5M | $2.7M |
| FCF MarginFCF / Revenue | -770.4% | 77.3% |
| Capex IntensityCapex / Revenue | 34.8% | 0.5% |
| Cash ConversionOCF / Net Profit | — | — |
| TTM Free Cash FlowTrailing 4 quarters | $-103.2M | $-7.8M |
8-quarter trend — quarters aligned by calendar period.
| Q4 25 | $-39.6M | $2.7M | ||
| Q3 25 | $-28.8M | $-4.0M | ||
| Q2 25 | $-14.8M | $-3.5M | ||
| Q1 25 | $-16.6M | $-3.0M | ||
| Q4 24 | $-14.6M | $-4.4M | ||
| Q3 24 | $-18.8M | $-3.0M | ||
| Q2 24 | $-9.9M | $-4.7M | ||
| Q1 24 | $-17.6M | $-2.3M |
| Q4 25 | $-41.5M | $2.7M | ||
| Q3 25 | $-29.7M | $-4.0M | ||
| Q2 25 | $-15.4M | $-3.5M | ||
| Q1 25 | $-16.6M | $-3.0M | ||
| Q4 24 | $-14.6M | — | ||
| Q3 24 | $-18.8M | $-3.0M | ||
| Q2 24 | — | $-4.8M | ||
| Q1 24 | $-17.7M | $-2.3M |
| Q4 25 | -770.4% | 77.3% | ||
| Q3 25 | -904.1% | -100.3% | ||
| Q2 25 | -768.8% | -85.9% | ||
| Q1 25 | -682.8% | -50.1% | ||
| Q4 24 | -566.7% | — | ||
| Q3 24 | -666.5% | -51.2% | ||
| Q2 24 | — | -60.1% | ||
| Q1 24 | -712.4% | -35.0% |
| Q4 25 | 34.8% | 0.5% | ||
| Q3 25 | 29.2% | 0.1% | ||
| Q2 25 | 26.4% | 0.7% | ||
| Q1 25 | 0.2% | 0.2% | ||
| Q4 24 | 0.1% | 0.0% | ||
| Q3 24 | 0.3% | 1.2% | ||
| Q2 24 | 0.0% | 0.8% | ||
| Q1 24 | 4.4% | 0.1% |
| Q4 25 | — | — | ||
| Q3 25 | — | -0.73× | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | — | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
Financial Flow Comparison
Revenue → gross profit → operating profit → net profit for each company.
Revenue Breakdown by Segment
TNXP
| Zembrace Symtouch | $3.1M | 58% |
| Other | $2.3M | 42% |
XXII
Segment breakdown not available.
