vs
AMICUS THERAPEUTICS, INC.（FOLD）与IONIS PHARMACEUTICALS INC（IONS）财务数据对比。点击上方公司名可切换其他公司
IONIS PHARMACEUTICALS INC的季度营收约是AMICUS THERAPEUTICS, INC.的1.1倍（$203.3M vs $185.2M），AMICUS THERAPEUTICS, INC.净利率更高（0.9% vs -112.8%，领先113.7%），AMICUS THERAPEUTICS, INC.同比增速更快（23.7% vs -10.3%），AMICUS THERAPEUTICS, INC.自由现金流更多（$16.0M vs $-159.0M），过去两年IONIS PHARMACEUTICALS INC的营收复合增速更高（30.4% vs 29.5%）
Amicus Therapeutics是总部位于美国宾夕法尼亚州费城的生物制药上市企业，2007年在纳斯达克挂牌上市，股票代码为FOLD。上市前，公司曾获得Radius Ventures、迦南合伙人、恩颐投资等多家风险投资机构的资金支持，专注于生物医药领域的研发与商业化布局。
IONIS制药是1989年成立的生物科技企业，总部位于美国加利福尼亚州卡尔斯巴德，专注于反义疗法、RNA干扰及CRISPR疗法的研发，2015年12月前曾以Isis制药的名称运营。
FOLD vs IONS — 直观对比
营收规模更大
IONS
是对方的1.1倍
$185.2M
营收增速更快
FOLD
高出34.0%
-10.3%
净利率更高
FOLD
高出113.7%
-112.8%
自由现金流更多
FOLD
多$175.0M
$-159.0M
两年增速更快
IONS
近两年复合增速
29.5%
损益表 — Q4 FY2025 vs Q4 FY2025
| 指标 | | |
|---|---|---|
| 营收 | $185.2M | $203.3M |
| 净利润 | $1.7M | $-229.4M |
| 毛利率 | 85.7% | 96.1% |
| 营业利润率 | 8.6% | -105.5% |
| 净利率 | 0.9% | -112.8% |
| 营收同比 | 23.7% | -10.3% |
| 净利润同比 | -88.5% | -119.8% |
| 每股收益（稀释后） | $0.00 | $-1.35 |
绿色 = 该指标领先。财年不对齐时期间可能不同
8季度营收与利润趋势
并排季度历史对比，按日历期对齐，财年错位的公司也能正确匹配
营收FOLDIONS
| Q4 25 | $185.2M | $203.3M | ||
| Q3 25 | $169.1M | $156.7M | ||
| Q2 25 | $154.7M | $452.0M | ||
| Q1 25 | $125.2M | $131.6M | ||
| Q4 24 | $149.7M | $226.6M | ||
| Q3 24 | $141.5M | $133.8M | ||
| Q2 24 | $126.7M | $225.3M | ||
| Q1 24 | $110.4M | $119.5M |
净利润FOLDIONS
| Q4 25 | $1.7M | $-229.4M | ||
| Q3 25 | $17.3M | $-128.6M | ||
| Q2 25 | $-24.4M | $123.6M | ||
| Q1 25 | $-21.7M | $-146.9M | ||
| Q4 24 | $14.7M | $-104.3M | ||
| Q3 24 | $-6.7M | $-140.5M | ||
| Q2 24 | $-15.7M | $-66.3M | ||
| Q1 24 | $-48.4M | $-142.8M |
毛利率FOLDIONS
| Q4 25 | 85.7% | 96.1% | ||
| Q3 25 | 88.5% | 98.5% | ||
| Q2 25 | 90.2% | 99.1% | ||
| Q1 25 | 90.7% | 98.9% | ||
| Q4 24 | 90.1% | 98.3% | ||
| Q3 24 | 90.6% | 99.2% | ||
| Q2 24 | 91.1% | 98.2% | ||
| Q1 24 | 87.7% | 98.2% |
营业利润率FOLDIONS
| Q4 25 | 8.6% | -105.5% | ||
| Q3 25 | 20.3% | -102.2% | ||
| Q2 25 | -6.1% | 30.9% | ||
| Q1 25 | -6.3% | -111.6% | ||
| Q4 24 | 10.7% | -48.9% | ||
| Q3 24 | 15.3% | -111.1% | ||
| Q2 24 | 11.8% | -29.3% | ||
| Q1 24 | -25.1% | -125.1% |
净利率FOLDIONS
| Q4 25 | 0.9% | -112.8% | ||
| Q3 25 | 10.2% | -82.1% | ||
| Q2 25 | -15.8% | 27.3% | ||
| Q1 25 | -17.3% | -111.6% | ||
| Q4 24 | 9.8% | -46.1% | ||
| Q3 24 | -4.8% | -105.0% | ||
| Q2 24 | -12.4% | -29.4% | ||
| Q1 24 | -43.9% | -119.5% |
每股收益（稀释后）FOLDIONS
| Q4 25 | $0.00 | $-1.35 | ||
| Q3 25 | $0.06 | $-0.80 | ||
| Q2 25 | $-0.08 | $0.70 | ||
| Q1 25 | $-0.07 | $-0.93 | ||
| Q4 24 | $0.05 | $-0.66 | ||
| Q3 24 | $-0.02 | $-0.95 | ||
| Q2 24 | $-0.05 | $-0.45 | ||
| Q1 24 | $-0.16 | $-0.98 |
资产负债表与财务实力
最新季度各公司的流动性、杠杆与账面价值一览
| 指标 | | |
|---|---|---|
| 现金及短期投资手头流动性 | $293.5M | $2.7B |
| 总债务越低越好 | $392.7M | $1.8B |
| 股东权益账面价值 | $274.2M | $489.1M |
| 总资产 | $949.9M | $3.5B |
| 负债/权益比越低杠杆越低 | 1.43× | 3.71× |
8季度趋势，按日历期对齐
现金及短期投资FOLDIONS
| Q4 25 | $293.5M | $2.7B | ||
| Q3 25 | $263.8M | $2.2B | ||
| Q2 25 | $231.0M | $2.3B | ||
| Q1 25 | $250.6M | $2.1B | ||
| Q4 24 | $249.9M | $2.3B | ||
| Q3 24 | $249.8M | $2.5B | ||
| Q2 24 | $260.1M | $2.1B | ||
| Q1 24 | $239.6M | $2.2B |
总债务FOLDIONS
| Q4 25 | $392.7M | $1.8B | ||
| Q3 25 | $392.0M | — | ||
| Q2 25 | $391.3M | — | ||
| Q1 25 | $390.7M | — | ||
| Q4 24 | $390.1M | $1.3B | ||
| Q3 24 | $389.5M | — | ||
| Q2 24 | $388.9M | — | ||
| Q1 24 | $388.4M | — |
股东权益FOLDIONS
| Q4 25 | $274.2M | $489.1M | ||
| Q3 25 | $230.4M | $618.0M | ||
| Q2 25 | $204.3M | $631.7M | ||
| Q1 25 | $193.6M | $475.7M | ||
| Q4 24 | $194.0M | $588.4M | ||
| Q3 24 | $178.8M | $662.5M | ||
| Q2 24 | $132.5M | $263.7M | ||
| Q1 24 | $130.7M | $296.5M |
总资产FOLDIONS
| Q4 25 | $949.9M | $3.5B | ||
| Q3 25 | $868.8M | $3.0B | ||
| Q2 25 | $815.3M | $3.0B | ||
| Q1 25 | $789.8M | $2.8B | ||
| Q4 24 | $785.0M | $3.0B | ||
| Q3 24 | $786.6M | $3.1B | ||
| Q2 24 | $749.5M | $2.7B | ||
| Q1 24 | $721.8M | $2.8B |
负债/权益比FOLDIONS
| Q4 25 | 1.43× | 3.71× | ||
| Q3 25 | 1.70× | — | ||
| Q2 25 | 1.92× | — | ||
| Q1 25 | 2.02× | — | ||
| Q4 24 | 2.01× | 2.13× | ||
| Q3 24 | 2.18× | — | ||
| Q2 24 | 2.93× | — | ||
| Q1 24 | 2.97× | — |
现金流与资本效率
扣除再投资后实际产生的现金。现金流比净利润更难造假
| 指标 | | |
|---|---|---|
| 经营现金流最新季度 | $16.3M | $-137.7M |
| 自由现金流经营现金流 - 资本支出 | $16.0M | $-159.0M |
| 自由现金流率自由现金流/营收 | 8.6% | -78.2% |
| 资本支出强度资本支出/营收 | 0.2% | 10.5% |
| 现金转化率经营现金流/净利润 | 9.62× | — |
| 过去12个月自由现金流最近4个季度 | $29.8M | $-320.0M |
8季度趋势，按日历期对齐
经营现金流FOLDIONS
| Q4 25 | $16.3M | $-137.7M | ||
| Q3 25 | $35.7M | $-131.4M | ||
| Q2 25 | $-26.5M | $151.3M | ||
| Q1 25 | $7.8M | $-150.8M | ||
| Q4 24 | $-3.9M | $-116.1M | ||
| Q3 24 | $-23.0M | $-115.0M | ||
| Q2 24 | $22.7M | $-119.9M | ||
| Q1 24 | $-29.7M | $-149.9M |
自由现金流FOLDIONS
| Q4 25 | $16.0M | $-159.0M | ||
| Q3 25 | $35.3M | $-136.7M | ||
| Q2 25 | $-28.9M | $139.0M | ||
| Q1 25 | $7.5M | $-163.4M | ||
| Q4 24 | $-4.2M | $-141.6M | ||
| Q3 24 | $-23.3M | $-124.0M | ||
| Q2 24 | $21.6M | $-126.1M | ||
| Q1 24 | $-31.5M | $-154.4M |
自由现金流率FOLDIONS
| Q4 25 | 8.6% | -78.2% | ||
| Q3 25 | 20.9% | -87.2% | ||
| Q2 25 | -18.7% | 30.8% | ||
| Q1 25 | 6.0% | -124.1% | ||
| Q4 24 | -2.8% | -62.5% | ||
| Q3 24 | -16.5% | -92.7% | ||
| Q2 24 | 17.0% | -56.0% | ||
| Q1 24 | -28.5% | -129.2% |
资本支出强度FOLDIONS
| Q4 25 | 0.2% | 10.5% | ||
| Q3 25 | 0.2% | 3.4% | ||
| Q2 25 | 1.6% | 2.7% | ||
| Q1 25 | 0.2% | 9.6% | ||
| Q4 24 | 0.2% | 11.3% | ||
| Q3 24 | 0.3% | 6.8% | ||
| Q2 24 | 0.9% | 2.8% | ||
| Q1 24 | 1.6% | 3.8% |
现金转化率FOLDIONS
| Q4 25 | 9.62× | — | ||
| Q3 25 | 2.06× | — | ||
| Q2 25 | — | 1.22× | ||
| Q1 25 | — | — | ||
| Q4 24 | -0.27× | — | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | — |
财务流量对比
营收 → 毛利润 → 营业利润 → 净利润流向图
业务分部营收拆解
FOLD
| Other | $105.8M | 57% |
| Galafold | $64.8M | 35% |
| Pombiliti Opfolda | $14.6M | 8% |
IONS
| Products | $58.0M | 29% |
| Spinraza Royalties | $54.0M | 27% |
| Collaborative Agreement Revenue | $52.4M | 26% |
| Wainus Royalties | $16.0M | 8% |
| Wainua Joint Development Revenue | $9.6M | 5% |
| Other Commercial | $7.6M | 4% |
| Other Royalties | $5.7M | 3% |
