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IONIS PHARMACEUTICALS INC（IONS）与Enpro Inc.（NPO）财务数据对比。点击上方公司名可切换其他公司
Enpro Inc.的季度营收约是IONIS PHARMACEUTICALS INC的1.5倍（$295.4M vs $203.3M），Enpro Inc.净利率更高（-10.8% vs -112.8%，领先102.0%），Enpro Inc.同比增速更快（14.3% vs -10.3%），过去两年IONIS PHARMACEUTICALS INC的营收复合增速更高（30.4% vs 7.1%）
IONIS制药是1989年成立的生物科技企业，总部位于美国加利福尼亚州卡尔斯巴德，专注于反义疗法、RNA干扰及CRISPR疗法的研发，2015年12月前曾以Isis制药的名称运营。
Enpro是总部位于美国的工业技术企业，面向半导体、航空航天、发电、重卡、农业机械、化工处理、浆纸、生命科学等技术密集型领域设计生产专用产品及材料。公司在全球12个国家布局61个核心生产基地，下设密封技术、先进表面技术及工程技术三大业务板块。
IONS vs NPO — 直观对比
营收规模更大
NPO
是对方的1.5倍
$203.3M
营收增速更快
NPO
高出24.6%
-10.3%
净利率更高
NPO
高出102.0%
-112.8%
两年增速更快
IONS
近两年复合增速
7.1%
损益表 — Q4 FY2025 vs Q4 FY2025
| 指标 | | |
|---|---|---|
| 营收 | $203.3M | $295.4M |
| 净利润 | $-229.4M | $-32.0M |
| 毛利率 | 96.1% | 42.1% |
| 营业利润率 | -105.5% | 11.2% |
| 净利率 | -112.8% | -10.8% |
| 营收同比 | -10.3% | 14.3% |
| 净利润同比 | -119.8% | -330.2% |
| 每股收益（稀释后） | $-1.35 | $-1.50 |
绿色 = 该指标领先。财年不对齐时期间可能不同
8季度营收与利润趋势
并排季度历史对比，按日历期对齐，财年错位的公司也能正确匹配
营收IONSNPO
| Q4 25 | $203.3M | $295.4M | ||
| Q3 25 | $156.7M | $286.6M | ||
| Q2 25 | $452.0M | $288.1M | ||
| Q1 25 | $131.6M | $273.2M | ||
| Q4 24 | $226.6M | $258.4M | ||
| Q3 24 | $133.8M | $260.9M | ||
| Q2 24 | $225.3M | $271.9M | ||
| Q1 24 | $119.5M | $257.5M |
净利润IONSNPO
| Q4 25 | $-229.4M | $-32.0M | ||
| Q3 25 | $-128.6M | $21.6M | ||
| Q2 25 | $123.6M | $26.4M | ||
| Q1 25 | $-146.9M | $24.5M | ||
| Q4 24 | $-104.3M | $13.9M | ||
| Q3 24 | $-140.5M | $19.8M | ||
| Q2 24 | $-66.3M | $26.7M | ||
| Q1 24 | $-142.8M | $12.5M |
毛利率IONSNPO
| Q4 25 | 96.1% | 42.1% | ||
| Q3 25 | 98.5% | 41.9% | ||
| Q2 25 | 99.1% | 43.3% | ||
| Q1 25 | 98.9% | 43.3% | ||
| Q4 24 | 98.3% | 42.3% | ||
| Q3 24 | 99.2% | 42.3% | ||
| Q2 24 | 98.2% | 43.8% | ||
| Q1 24 | 98.2% | 41.2% |
营业利润率IONSNPO
| Q4 25 | -105.5% | 11.2% | ||
| Q3 25 | -102.2% | 14.3% | ||
| Q2 25 | 30.9% | 15.9% | ||
| Q1 25 | -111.6% | 15.3% | ||
| Q4 24 | -48.9% | 12.5% | ||
| Q3 24 | -111.1% | 13.1% | ||
| Q2 24 | -29.3% | 17.7% | ||
| Q1 24 | -125.1% | 10.9% |
净利率IONSNPO
| Q4 25 | -112.8% | -10.8% | ||
| Q3 25 | -82.1% | 7.5% | ||
| Q2 25 | 27.3% | 9.2% | ||
| Q1 25 | -111.6% | 9.0% | ||
| Q4 24 | -46.1% | 5.4% | ||
| Q3 24 | -105.0% | 7.6% | ||
| Q2 24 | -29.4% | 9.8% | ||
| Q1 24 | -119.5% | 4.9% |
每股收益（稀释后）IONSNPO
| Q4 25 | $-1.35 | $-1.50 | ||
| Q3 25 | $-0.80 | $1.01 | ||
| Q2 25 | $0.70 | $1.25 | ||
| Q1 25 | $-0.93 | $1.15 | ||
| Q4 24 | $-0.66 | $0.65 | ||
| Q3 24 | $-0.95 | $0.94 | ||
| Q2 24 | $-0.45 | $1.27 | ||
| Q1 24 | $-0.98 | $0.59 |
资产负债表与财务实力
最新季度各公司的流动性、杠杆与账面价值一览
| 指标 | | |
|---|---|---|
| 现金及短期投资手头流动性 | $2.7B | $114.7M |
| 总债务越低越好 | $1.8B | $655.3M |
| 股东权益账面价值 | $489.1M | $1.5B |
| 总资产 | $3.5B | $2.7B |
| 负债/权益比越低杠杆越低 | 3.71× | 0.42× |
8季度趋势，按日历期对齐
现金及短期投资IONSNPO
| Q4 25 | $2.7B | $114.7M | ||
| Q3 25 | $2.2B | $132.9M | ||
| Q2 25 | $2.3B | $107.1M | ||
| Q1 25 | $2.1B | $240.3M | ||
| Q4 24 | $2.3B | $236.3M | ||
| Q3 24 | $2.5B | $206.9M | ||
| Q2 24 | $2.1B | $175.9M | ||
| Q1 24 | $2.2B | $163.9M |
总债务IONSNPO
| Q4 25 | $1.8B | $655.3M | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | $1.3B | $640.1M | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | $644.9M |
股东权益IONSNPO
| Q4 25 | $489.1M | $1.5B | ||
| Q3 25 | $618.0M | $1.5B | ||
| Q2 25 | $631.7M | $1.5B | ||
| Q1 25 | $475.7M | $1.5B | ||
| Q4 24 | $588.4M | $1.4B | ||
| Q3 24 | $662.5M | $1.5B | ||
| Q2 24 | $263.7M | $1.4B | ||
| Q1 24 | $296.5M | $1.4B |
总资产IONSNPO
| Q4 25 | $3.5B | $2.7B | ||
| Q3 25 | $3.0B | $2.4B | ||
| Q2 25 | $3.0B | $2.4B | ||
| Q1 25 | $2.8B | $2.5B | ||
| Q4 24 | $3.0B | $2.5B | ||
| Q3 24 | $3.1B | $2.5B | ||
| Q2 24 | $2.7B | $2.5B | ||
| Q1 24 | $2.8B | $2.5B |
负债/权益比IONSNPO
| Q4 25 | 3.71× | 0.42× | ||
| Q3 25 | — | — | ||
| Q2 25 | — | — | ||
| Q1 25 | — | — | ||
| Q4 24 | 2.13× | 0.45× | ||
| Q3 24 | — | — | ||
| Q2 24 | — | — | ||
| Q1 24 | — | 0.46× |
现金流与资本效率
扣除再投资后实际产生的现金。现金流比净利润更难造假
| 指标 | | |
|---|---|---|
| 经营现金流最新季度 | $-137.7M | — |
| 自由现金流经营现金流 - 资本支出 | $-159.0M | — |
| 自由现金流率自由现金流/营收 | -78.2% | — |
| 资本支出强度资本支出/营收 | 10.5% | 4.1% |
| 现金转化率经营现金流/净利润 | — | — |
| 过去12个月自由现金流最近4个季度 | $-320.0M | — |
8季度趋势，按日历期对齐
经营现金流IONSNPO
| Q4 25 | $-137.7M | — | ||
| Q3 25 | $-131.4M | $65.3M | ||
| Q2 25 | $151.3M | $52.2M | ||
| Q1 25 | $-150.8M | $21.0M | ||
| Q4 24 | $-116.1M | $59.4M | ||
| Q3 24 | $-115.0M | $54.0M | ||
| Q2 24 | $-119.9M | $43.2M | ||
| Q1 24 | $-149.9M | $6.3M |
自由现金流IONSNPO
| Q4 25 | $-159.0M | — | ||
| Q3 25 | $-136.7M | $53.4M | ||
| Q2 25 | $139.0M | $42.3M | ||
| Q1 25 | $-163.4M | $13.0M | ||
| Q4 24 | $-141.6M | $49.1M | ||
| Q3 24 | $-124.0M | $48.3M | ||
| Q2 24 | $-126.1M | $38.3M | ||
| Q1 24 | $-154.4M | $-1.9M |
自由现金流率IONSNPO
| Q4 25 | -78.2% | — | ||
| Q3 25 | -87.2% | 18.6% | ||
| Q2 25 | 30.8% | 14.7% | ||
| Q1 25 | -124.1% | 4.8% | ||
| Q4 24 | -62.5% | 19.0% | ||
| Q3 24 | -92.7% | 18.5% | ||
| Q2 24 | -56.0% | 14.1% | ||
| Q1 24 | -129.2% | -0.7% |
资本支出强度IONSNPO
| Q4 25 | 10.5% | 4.1% | ||
| Q3 25 | 3.4% | 4.2% | ||
| Q2 25 | 2.7% | 3.4% | ||
| Q1 25 | 9.6% | 2.9% | ||
| Q4 24 | 11.3% | 4.0% | ||
| Q3 24 | 6.8% | 2.2% | ||
| Q2 24 | 2.8% | 1.8% | ||
| Q1 24 | 3.8% | 3.2% |
现金转化率IONSNPO
| Q4 25 | — | — | ||
| Q3 25 | — | 3.02× | ||
| Q2 25 | 1.22× | 1.98× | ||
| Q1 25 | — | 0.86× | ||
| Q4 24 | — | 4.27× | ||
| Q3 24 | — | 2.73× | ||
| Q2 24 | — | 1.62× | ||
| Q1 24 | — | 0.50× |
财务流量对比
营收 → 毛利润 → 营业利润 → 净利润流向图
业务分部营收拆解
IONS
| Products | $58.0M | 29% |
| Spinraza Royalties | $54.0M | 27% |
| Collaborative Agreement Revenue | $52.4M | 26% |
| Wainus Royalties | $16.0M | 8% |
| Wainua Joint Development Revenue | $9.6M | 5% |
| Other Commercial | $7.6M | 4% |
| Other Royalties | $5.7M | 3% |
NPO
| Sealing Technologies Segment | $187.0M | 63% |
| General Industrial | $71.3M | 24% |
| Power Generation | $19.9M | 7% |
| Oiland Gas Market | $15.0M | 5% |
| Semiconductors | $2.2M | 1% |
