Karyopharm Therapeutics Inc.KPTIEarnings & Financial Report
Nasdaq
KPTI Q4 2025 Key Financial Metrics
Revenue
$34.1M
Gross Profit
N/A
Operating Profit
$-17.8M
Net Profit
$-102.2M
Gross Margin
N/A
Operating Margin
-52.4%
Net Margin
-299.9%
YoY Growth
11.6%
EPS
$-7.02
Financial Flow
Karyopharm Therapeutics Inc. Q4 2025 Financial Summary
Karyopharm Therapeutics Inc. reported revenue of $34.1M for Q4 2025, with a net profit of $-102.2M (-299.9% margin). Cost of goods sold was N/A, operating expenses totaled N/A.
Key Financial Metrics
| Total Revenue | $34.1M |
|---|---|
| Net Profit | $-102.2M |
| Gross Margin | N/A |
| Operating Margin | -52.4% |
| Report Period | Q4 2025 |
Karyopharm Therapeutics Inc. Annual Revenue by Year
Karyopharm Therapeutics Inc. annual revenue history includes year-by-year totals (for example, 2025 revenue was $146.1M).
| Year | Annual Revenue |
|---|---|
| 2025 | $146.1M |
| 2024 | $145.2M |
| 2023 | $146.0M |
| 2022 | $157.1M |
Income Statement
| Q1 2024 | Q2 2024 | Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | $33.1M | $42.8M | $38.8M | $30.5M | $30.0M | $37.9M | $44.0M | $34.1M |
| YoY Growth | -14.4% | 13.9% | 7.7% | -9.5% | -9.4% | -11.4% | 13.6% | 11.6% |
Balance Sheet
| Q1 2024 | Q2 2024 | Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | |
|---|---|---|---|---|---|---|---|---|
| Assets | $204.5M | $214.0M | $189.5M | $164.4M | $127.7M | $104.9M | $96.2M | $108.4M |
| Liabilities | $373.4M | $346.1M | $349.1M | $350.4M | $333.6M | $343.8M | $365.5M | $401.3M |
| Equity | $-169.0M | $-132.1M | $-159.6M | $-186.0M | $-205.9M | $-238.9M | $-269.3M | $-292.9M |
Cash Flow
| Q1 2024 | Q2 2024 | Q3 2024 | Q4 2024 | Q1 2025 | Q2 2025 | Q3 2025 | Q4 2025 | |
|---|---|---|---|---|---|---|---|---|
| Operating CF | $-43.7M | $-38.5M | $-19.5M | $-25.8M | $-39.0M | $-18.7M | $-5.9M | $-11.8M |