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Side-by-side financial comparison of ACADIA PHARMACEUTICALS INC (ACAD) and Portillo's Inc. (PTLO). Click either name above to swap in a different company.

ACADIA PHARMACEUTICALS INC is the larger business by last-quarter revenue ($284.0M vs $185.7M, roughly 1.5× Portillo's Inc.). ACADIA PHARMACEUTICALS INC runs the higher net margin — 96.3% vs 3.4%, a 93.0% gap on every dollar of revenue. On growth, ACADIA PHARMACEUTICALS INC posted the faster year-over-year revenue change (9.4% vs 0.6%). Over the past eight quarters, ACADIA PHARMACEUTICALS INC's revenue compounded faster (17.5% CAGR vs 5.8%).

Acadia Pharmaceuticals Inc. is a biopharmaceutical company headquartered in Del Mar, San Diego, California.

Portillo's Restaurant Group, Inc. is an American fast casual restaurant chain based in the Chicago area that specializes in serving Chicago-style food such as hot dogs, Maxwell Street Polish, and Italian beef. The company was founded by Dick Portillo on April 9, 1963, in Villa Park, Illinois, under the name "The Dog House".

ACAD vs PTLO — Head-to-Head

Bigger by revenue
ACAD
ACAD
1.5× larger
ACAD
$284.0M
$185.7M
PTLO
Growing faster (revenue YoY)
ACAD
ACAD
+8.8% gap
ACAD
9.4%
0.6%
PTLO
Higher net margin
ACAD
ACAD
93.0% more per $
ACAD
96.3%
3.4%
PTLO
Faster 2-yr revenue CAGR
ACAD
ACAD
Annualised
ACAD
17.5%
5.8%
PTLO

Income Statement — Q4 FY2025 vs Q4 FY2025

Metric
ACAD
ACAD
PTLO
PTLO
Revenue
$284.0M
$185.7M
Net Profit
$273.6M
$6.3M
Gross Margin
90.8%
Operating Margin
6.1%
5.6%
Net Margin
96.3%
3.4%
Revenue YoY
9.4%
0.6%
Net Profit YoY
90.3%
-49.5%
EPS (diluted)
$1.61
$0.08

Green = leading value per metric. Periods may differ when fiscal calendars don't align.

8-Quarter Revenue & Profit Trend

Side-by-side quarterly history. Quarters aligned by calendar period so offset fiscal years line up.

Revenue
ACAD
ACAD
PTLO
PTLO
Q4 25
$284.0M
$185.7M
Q3 25
$278.6M
$181.4M
Q2 25
$264.6M
$188.5M
Q1 25
$244.3M
$176.4M
Q4 24
$259.6M
$184.6M
Q3 24
$250.4M
$178.3M
Q2 24
$242.0M
$181.9M
Q1 24
$205.8M
$165.8M
Net Profit
ACAD
ACAD
PTLO
PTLO
Q4 25
$273.6M
$6.3M
Q3 25
$71.8M
$1.2M
Q2 25
$26.7M
$8.7M
Q1 25
$19.0M
$3.3M
Q4 24
$143.7M
$12.4M
Q3 24
$32.8M
$7.2M
Q2 24
$33.4M
$6.5M
Q1 24
$16.6M
$4.6M
Gross Margin
ACAD
ACAD
PTLO
PTLO
Q4 25
90.8%
Q3 25
92.2%
Q2 25
92.2%
Q1 25
91.7%
Q4 24
91.6%
Q3 24
92.5%
Q2 24
92.5%
Q1 24
88.8%
Operating Margin
ACAD
ACAD
PTLO
PTLO
Q4 25
6.1%
5.6%
Q3 25
12.8%
3.0%
Q2 25
12.2%
9.3%
Q1 25
7.9%
5.9%
Q4 24
59.1%
7.5%
Q3 24
12.6%
9.0%
Q2 24
12.6%
10.0%
Q1 24
7.4%
6.1%
Net Margin
ACAD
ACAD
PTLO
PTLO
Q4 25
96.3%
3.4%
Q3 25
25.8%
0.7%
Q2 25
10.1%
4.6%
Q1 25
7.8%
1.9%
Q4 24
55.4%
6.7%
Q3 24
13.1%
4.1%
Q2 24
13.8%
3.6%
Q1 24
8.0%
2.8%
EPS (diluted)
ACAD
ACAD
PTLO
PTLO
Q4 25
$1.61
$0.08
Q3 25
$0.42
$0.02
Q2 25
$0.16
$0.12
Q1 25
$0.11
$0.05
Q4 24
$0.86
$0.17
Q3 24
$0.20
$0.11
Q2 24
$0.20
$0.10
Q1 24
$0.10
$0.08

Balance Sheet & Financial Strength

Snapshot of each company's liquidity, leverage and book value from the latest quarter.

Metric
ACAD
ACAD
PTLO
PTLO
Cash + ST InvestmentsLiquidity on hand
$177.7M
Total DebtLower is stronger
$334.2M
Stockholders' EquityBook value
$1.2B
$467.8M
Total Assets
$1.6B
$1.6B
Debt / EquityLower = less leverage
0.71×

8-quarter trend — quarters aligned by calendar period.

Cash + ST Investments
ACAD
ACAD
PTLO
PTLO
Q4 25
$177.7M
Q3 25
$258.0M
Q2 25
$253.6M
Q1 25
$217.7M
Q4 24
$319.6M
Q3 24
$155.1M
Q2 24
$177.1M
Q1 24
$204.7M
Total Debt
ACAD
ACAD
PTLO
PTLO
Q4 25
$334.2M
Q3 25
$322.6M
Q2 25
$317.0M
Q1 25
$319.8M
Q4 24
$311.7M
Q3 24
$302.2M
Q2 24
$305.1M
Q1 24
$321.7M
Stockholders' Equity
ACAD
ACAD
PTLO
PTLO
Q4 25
$1.2B
$467.8M
Q3 25
$917.3M
$459.4M
Q2 25
$822.4M
$458.9M
Q1 25
$765.2M
$406.9M
Q4 24
$732.8M
$401.1M
Q3 24
$577.2M
$382.4M
Q2 24
$516.7M
$370.2M
Q1 24
$464.0M
$360.5M
Total Assets
ACAD
ACAD
PTLO
PTLO
Q4 25
$1.6B
$1.6B
Q3 25
$1.3B
$1.6B
Q2 25
$1.2B
$1.6B
Q1 25
$1.1B
$1.5B
Q4 24
$1.2B
$1.5B
Q3 24
$976.9M
$1.5B
Q2 24
$914.1M
$1.4B
Q1 24
$855.1M
$1.4B
Debt / Equity
ACAD
ACAD
PTLO
PTLO
Q4 25
0.71×
Q3 25
0.70×
Q2 25
0.69×
Q1 25
0.79×
Q4 24
0.78×
Q3 24
0.79×
Q2 24
0.82×
Q1 24
0.89×

Cash Flow & Capital Efficiency

How much cash each business actually produces after reinvestment. Cash flow is harder to manipulate than net income.

Metric
ACAD
ACAD
PTLO
PTLO
Operating Cash FlowLast quarter
$-48.7M
$23.2M
Free Cash FlowOCF − Capex
$-9.2M
FCF MarginFCF / Revenue
-4.9%
Capex IntensityCapex / Revenue
17.4%
Cash ConversionOCF / Net Profit
-0.18×
3.69×
TTM Free Cash FlowTrailing 4 quarters
$-18.5M

8-quarter trend — quarters aligned by calendar period.

Operating Cash Flow
ACAD
ACAD
PTLO
PTLO
Q4 25
$-48.7M
$23.2M
Q3 25
$74.3M
$20.0M
Q2 25
$64.0M
$19.2M
Q1 25
$20.3M
$9.4M
Q4 24
$40.4M
$26.1M
Q3 24
$63.2M
$30.3M
Q2 24
$25.0M
$32.6M
Q1 24
$29.1M
$9.1M
Free Cash Flow
ACAD
ACAD
PTLO
PTLO
Q4 25
$-9.2M
Q3 25
$73.9M
$-5.0M
Q2 25
$5.2M
Q1 25
$-9.6M
Q4 24
$-5.6M
Q3 24
$63.2M
$7.7M
Q2 24
$15.6M
Q1 24
$-7.9M
FCF Margin
ACAD
ACAD
PTLO
PTLO
Q4 25
-4.9%
Q3 25
26.5%
-2.7%
Q2 25
2.8%
Q1 25
-5.4%
Q4 24
-3.0%
Q3 24
25.2%
4.3%
Q2 24
8.6%
Q1 24
-4.7%
Capex Intensity
ACAD
ACAD
PTLO
PTLO
Q4 25
17.4%
Q3 25
0.1%
13.8%
Q2 25
7.5%
Q1 25
10.8%
Q4 24
17.2%
Q3 24
0.0%
12.7%
Q2 24
9.3%
Q1 24
10.2%
Cash Conversion
ACAD
ACAD
PTLO
PTLO
Q4 25
-0.18×
3.69×
Q3 25
1.03×
16.51×
Q2 25
2.40×
2.21×
Q1 25
1.07×
2.85×
Q4 24
0.28×
2.10×
Q3 24
1.93×
4.20×
Q2 24
0.75×
5.03×
Q1 24
1.76×
1.99×

Financial Flow Comparison

Revenue → gross profit → operating profit → net profit for each company.

Revenue Breakdown by Segment

ACAD
ACAD

Nuplazid$174.4M61%
Daybue$109.6M39%

PTLO
PTLO

Segment breakdown not available.

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